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Page 1
DUSP1 protects against ischemic acute kidney injury through stabilizing mtDNA via interaction with JNK.
Shi L, Zha H, Pan Z, Wang J, Xia Y, Li H, Huang H, Yue R, Song Z, Zhu J. Shi L, et al. Cell Death Dis. 2023 Nov 7;14(11):724. doi: 10.1038/s41419-023-06247-4. Cell Death Dis. 2023. PMID: 37935658 Free PMC article.
Mechanistically, DUSP1 could directly bind to JNK, and DUSP1 deficiency could lead to aberrant phosphorylation of JNK and BAX mitochondria translocation. ...Furthermore, STING knockout or JNK inhibition could significantly mitigate the adverse effects of DUSP1 …
Mechanistically, DUSP1 could directly bind to JNK, and DUSP1 deficiency could lead to aberrant phosphorylation of JNK and BAX …
DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways.
Jin Q, Li R, Hu N, Xin T, Zhu P, Hu S, Ma S, Zhu H, Ren J, Zhou H. Jin Q, et al. Redox Biol. 2018 Apr;14:576-587. doi: 10.1016/j.redox.2017.11.004. Epub 2017 Nov 6. Redox Biol. 2018. PMID: 29149759 Free PMC article.
Here, we demonstrated that cardiac DUSP1 was downregulated following acute cardiac IR injury. In vivo, compared to wild-type mice, DUSP1 transgenic mice (DUSP1(TG) mice) demonstrated a smaller infarcted area and the improved myocardial function. In vitro, the …
Here, we demonstrated that cardiac DUSP1 was downregulated following acute cardiac IR injury. In vivo, compared to wild-type mice, …
The Ninj1/Dusp1 Axis Contributes to Liver Ischemia Reperfusion Injury by Regulating Macrophage Activation and Neutrophil Infiltration.
Hu Y, Zhan F, Wang Y, Wang D, Lu H, Wu C, Xia Y, Meng L, Zhang F, Wang X, Zhou S. Hu Y, et al. Cell Mol Gastroenterol Hepatol. 2023;15(5):1071-1084. doi: 10.1016/j.jcmgh.2023.01.008. Epub 2023 Jan 31. Cell Mol Gastroenterol Hepatol. 2023. PMID: 36731792 Free PMC article.
In vitro and in vivo, using small-interfering RNA against dual-specificity phosphatase 1 (DUSP1), we found that Ninj1 deficiency diminished the inflammatory response in KCs and neutrophil infiltration through DUSP1-dependent deactivation of the c-Jun-N-terminal kina …
In vitro and in vivo, using small-interfering RNA against dual-specificity phosphatase 1 (DUSP1), we found that Ninj1 deficiency dimi …
DUSP1 interacts with and dephosphorylates VCP to improve mitochondrial quality control against endotoxemia-induced myocardial dysfunction.
Zhu H, Wang J, Xin T, Chen S, Hu R, Li Y, Zhang M, Zhou H. Zhu H, et al. Cell Mol Life Sci. 2023 Jul 18;80(8):213. doi: 10.1007/s00018-023-04863-z. Cell Mol Life Sci. 2023. PMID: 37464072 Free PMC article.
We addressed this issue by modeling LPS-induced endotoxemia in DUSP1 transgenic (DUSP1(TG)) mice and in cultured DUSP1-overexpressing HL-1 cardiomyocytes. ...Molecular assays showed that VCP was a substrate of DUSP1 and the interaction between DUSP1 …
We addressed this issue by modeling LPS-induced endotoxemia in DUSP1 transgenic (DUSP1(TG)) mice and in cultured DUSP1- …
Role of DUSP1/MKP1 in tumorigenesis, tumor progression and therapy.
Shen J, Zhang Y, Yu H, Shen B, Liang Y, Jin R, Liu X, Shi L, Cai X. Shen J, et al. Cancer Med. 2016 Aug;5(8):2061-8. doi: 10.1002/cam4.772. Epub 2016 May 26. Cancer Med. 2016. PMID: 27227569 Free PMC article. Review.
In various human cancers, abnormal expression of DUSP1 was observed which was associated with prognosis of tumor patients. ...In this review, we will focus on the function and mechanism of DUSP1 in tumor cells and tumor treatment....
In various human cancers, abnormal expression of DUSP1 was observed which was associated with prognosis of tumor patients. ...In this …
Cellular degradation systems in ferroptosis.
Chen X, Yu C, Kang R, Kroemer G, Tang D. Chen X, et al. Cell Death Differ. 2021 Apr;28(4):1135-1148. doi: 10.1038/s41418-020-00728-1. Epub 2021 Jan 18. Cell Death Differ. 2021. PMID: 33462411 Free PMC article. Review.
., BECN1, STING1/TMEM173, CTSB, HMGB1, PEBP1, MTOR, AMPK, and DUSP1) also determine the ferroptotic response in a context-dependent manner. ...
., BECN1, STING1/TMEM173, CTSB, HMGB1, PEBP1, MTOR, AMPK, and DUSP1) also determine the ferroptotic response in a context-dependent m …
DUSP1 Signaling Pathway Regulates Cytarabine Sensitivity in Acute Myeloid Leukemia.
Sun H, Ren Y, Zhou X, Chen Q, Liu Y, Zhu C, Ruan Y, Ruan H, Tong H, Ying S, Lin P. Sun H, et al. Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231207765. doi: 10.1177/15330338231207765. Technol Cancer Res Treat. 2023. PMID: 37872685 Free PMC article.
Results: We found that the expression levels of DUSP1 in AML patients exceeded that in controls. Survival analysis in public datasets showed that AML patients with higher levels of DUSP1 had poor clinical outcomes. Further public data analysis indicated that DUSP …
Results: We found that the expression levels of DUSP1 in AML patients exceeded that in controls. Survival analysis in public datasets …
DUSP1 promotes muscle atrophy by inhibiting myocyte differentiation in cachectic patients.
Sui X, Mao X, Wu G, Meng Q. Sui X, et al. Front Oncol. 2022 Nov 1;12:1040112. doi: 10.3389/fonc.2022.1040112. eCollection 2022. Front Oncol. 2022. PMID: 36387242 Free PMC article.
Function of DUSP1 on myogenesis was clarified by qPCR, western blotting, and immunofluorescence. ...Significant changes of myogenesis related genes were observed in myocyte after DUSP1 was overexpressed and knocked down. CONCLUSION: In skeletal muscle of cachectic p …
Function of DUSP1 on myogenesis was clarified by qPCR, western blotting, and immunofluorescence. ...Significant changes of myogenesis …
DUSP1 regulates hippocampal damage in epilepsy rats via ERK1/2 pathway.
Shao LL, Gao MM, Gong JX, Yang LY. Shao LL, et al. J Chem Neuroanat. 2021 Dec;118:102032. doi: 10.1016/j.jchemneu.2021.102032. Epub 2021 Sep 23. J Chem Neuroanat. 2021. PMID: 34562585
OBJECTIVE: To investigate the effects of DUSP1 on the hippocampal injury of young rats with epilepsy (EP) through mediating ERK1/2 signaling pathway. ...The EP rats treated with LV-DUSP1 showed obvious improvements regarding the above indicators, while those treated …
OBJECTIVE: To investigate the effects of DUSP1 on the hippocampal injury of young rats with epilepsy (EP) through mediating ERK1/2 si …
DUSP1 recuses diabetic nephropathy via repressing JNK-Mff-mitochondrial fission pathways.
Sheng J, Li H, Dai Q, Lu C, Xu M, Zhang J, Feng J. Sheng J, et al. J Cell Physiol. 2019 Mar;234(3):3043-3057. doi: 10.1002/jcp.27124. Epub 2018 Sep 7. J Cell Physiol. 2019. PMID: 30191967
In the current study, we found that dual-specificity protein phosphatase-1 (DUSP1) was actually downregulated by chronic hyperglycemia stimulus. Lower DUSP1 expression was associated with glucose metabolism disorder, renal dysfunction, kidney hypertrophy, renal fibr …
In the current study, we found that dual-specificity protein phosphatase-1 (DUSP1) was actually downregulated by chronic hyperglycemi …
1,482 results