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Page 1
DUSP26 induces aortic valve calcification by antagonizing MDM2-mediated ubiquitination of DPP4 in human valvular interstitial cells.
Wang Y, Han D, Zhou T, Chen C, Cao H, Zhang JZ, Ma N, Liu C, Song M, Shi J, Jin X, Cao F, Dong N. Wang Y, et al. Eur Heart J. 2021 Aug 7;42(30):2935-2951. doi: 10.1093/eurheartj/ehab316. Eur Heart J. 2021. PMID: 34179958
Immunoprecipitation, liquid chromatography-tandem mass spectrometry, and functional assays revealed that dipeptidyl peptidase-4 (DPP4) interacted with DUSP26 to mediate the procalcific effects of DUSP26. High N6-methyladenosine levels up-regulated DUSP26 in C …
Immunoprecipitation, liquid chromatography-tandem mass spectrometry, and functional assays revealed that dipeptidyl peptidase-4 (DPP4) inter …
A Review of DUSP26: Structure, Regulation and Relevance in Human Disease.
Thompson EM, Stoker AW. Thompson EM, et al. Int J Mol Sci. 2021 Jan 14;22(2):776. doi: 10.3390/ijms22020776. Int J Mol Sci. 2021. PMID: 33466673 Free PMC article. Review.
The residues that govern DUSP26 substrate specificity are yet to be determined; however, recent evidence suggests that interactions with a binding partner may be required for DUSP26 catalytic activity. ...Here we review DUSP26 by evaluating its transcriptiona …
The residues that govern DUSP26 substrate specificity are yet to be determined; however, recent evidence suggests that interactions w …
Dusp26 phosphatase regulates mitochondrial respiration and oxidative stress and protects neuronal cell death.
Eroglu B, Jin X, Deane S, Öztürk B, Ross OA, Moskophidis D, Mivechi NF. Eroglu B, et al. Cell Mol Life Sci. 2022 Mar 21;79(4):198. doi: 10.1007/s00018-022-04162-z. Cell Mol Life Sci. 2022. PMID: 35313355 Free PMC article.
The mitochondrial dysregulation in dusp26-deficient neuroblastoma cells leads to the inhibition of cell proliferation and cell death. In vivo, Dusp26 is highly expressed in neurons in different brain regions, including cortex and midbrain (MB). ...
The mitochondrial dysregulation in dusp26-deficient neuroblastoma cells leads to the inhibition of cell proliferation and cell death. …
Decreased DUSP26 Expression Promotes Malignant Behavior in Glioblastoma Cells via Deregulation of MAPK and Akt Signaling Pathway.
Chen J, Zeng Y, Wu R, Xuan Y, Jiang M, Teng H. Chen J, et al. Front Oncol. 2021 Feb 25;11:622826. doi: 10.3389/fonc.2021.622826. eCollection 2021. Front Oncol. 2021. PMID: 33718185 Free PMC article.
Stratification of glioma patients based on DUSP26 expression level showed an inverse correlation between DUSP26 expression and patient survival. ...DUSP26 can serve as an independent prognostic factor....
Stratification of glioma patients based on DUSP26 expression level showed an inverse correlation between DUSP26 expression and …
DUSP26 regulates podocyte oxidative stress and fibrosis in a mouse model with diabetic nephropathy through the mediation of ROS.
Huang F, Sheng XX, Zhang HJ. Huang F, et al. Biochem Biophys Res Commun. 2019 Jul 30;515(3):410-416. doi: 10.1016/j.bbrc.2019.05.032. Epub 2019 May 30. Biochem Biophys Res Commun. 2019. PMID: 31155289
However, its role in the development of DN is still vague. In this study, we found that DUSP26 expression was increased in kidney of DN patients. Then, the wild type (DUSP26(+/+)) and gene knockout (DUSP26(-/-)) mice were used to further explore the effects o …
However, its role in the development of DN is still vague. In this study, we found that DUSP26 expression was increased in kidney of …
NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish.
Yang CH, Yeh YJ, Wang JY, Liu YW, Chen YL, Cheng HW, Cheng CM, Chuang YJ, Yuh CH, Chen YR. Yang CH, et al. Sci Rep. 2017 Jul 12;7(1):5241. doi: 10.1038/s41598-017-05584-7. Sci Rep. 2017. PMID: 28701747 Free PMC article.
Expression of neuroendocrine-associated phosphatase (NEAP, also named as dual specificity phosphatase 26, [DUSP26]) is restricted to neuroendocrine tissues. We found that NEAP, but not its phosphatase-defective mutant, suppressed nerve growth factor (NGF) receptor TrkA and …
Expression of neuroendocrine-associated phosphatase (NEAP, also named as dual specificity phosphatase 26, [DUSP26]) is restricted to …
DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs.
Patterson KI, Brummer T, Daly RJ, O'Brien PM. Patterson KI, et al. Biochim Biophys Acta. 2010 Sep;1803(9):1003-12. doi: 10.1016/j.bbamcr.2010.03.014. Epub 2010 Mar 27. Biochim Biophys Acta. 2010. PMID: 20347885 Free article.
DUSP26 mRNA expression was reduced in neuroblastoma, brain and ovarian cancer cell lines. ...In addition, they indicate that DUSP26 may function as a tumour suppressor in particular cancers....
DUSP26 mRNA expression was reduced in neuroblastoma, brain and ovarian cancer cell lines. ...In addition, they indicate that DUSP2 …
NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis.
Shi Y, Ma IT, Patel RH, Shang X, Chen Z, Zhao Y, Cheng J, Fan Y, Rojas Y, Barbieri E, Chen Z, Yu Y, Jin J, Kim ES, Shohet JM, Vasudevan SA, Yang J. Shi Y, et al. Cell Death Dis. 2015 Aug 6;6(8):e1841. doi: 10.1038/cddis.2015.207. Cell Death Dis. 2015. PMID: 26247726 Free PMC article.
In vitro, DUSP26 has also been shown to effectively inhibit p38 MAP kinase. We hypothesize that inhibiting DUSP26 will result in decreased NB cell growth in a p53 and/or p38-mediated manner. ...
In vitro, DUSP26 has also been shown to effectively inhibit p38 MAP kinase. We hypothesize that inhibiting DUSP26 will result …
The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth.
Kim H, Lee HJ, Oh Y, Choi SG, Hong SH, Kim HJ, Lee SY, Choi JW, Su Hwang D, Kim KS, Kim HJ, Zhang J, Youn HJ, Noh DY, Jung YK. Kim H, et al. Nat Commun. 2014;5:3351. doi: 10.1038/ncomms4351. Nat Commun. 2014. PMID: 24548998 Free PMC article.
Here we show that AK2 negatively regulates tumour cell growth. AK2 forms a complex with dual-specificity phosphatase 26 (DUSP26) phosphatase and stimulates DUSP26 activity independently of its AK activity. AK2/DUSP26 phosphatase protein complex dephosphorylat …
Here we show that AK2 negatively regulates tumour cell growth. AK2 forms a complex with dual-specificity phosphatase 26 (DUSP26) phos …
Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion.
Tanuma N, Nomura M, Ikeda M, Kasugai I, Tsubaki Y, Takagaki K, Kawamura T, Yamashita Y, Sato I, Sato M, Katakura R, Kikuchi K, Shima H. Tanuma N, et al. Oncogene. 2009 Feb 5;28(5):752-61. doi: 10.1038/onc.2008.431. Epub 2008 Dec 1. Oncogene. 2009. PMID: 19043453
We also showed that Dusp26 mRNA expression was downregulated in human glioblastoma samples. These results suggest previously unidentified functions of Dusp26 in intracellular transport and cell-cell adhesion. Downregulation of Dusp26 may contribute to maligna …
We also showed that Dusp26 mRNA expression was downregulated in human glioblastoma samples. These results suggest previously unidenti …
46 results