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Year Number of Results
1993 1
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1999 3
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2001 5
2002 5
2003 14
2004 11
2005 7
2006 22
2007 19
2008 26
2009 28
2010 33
2011 39
2012 56
2013 57
2014 48
2015 54
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2017 56
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925 results

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Page 1
DYRK1A inhibitors for disease therapy: Current status and perspectives.
Liu T, Wang Y, Wang J, Ren C, Chen H, Zhang J. Liu T, et al. Eur J Med Chem. 2022 Feb 5;229:114062. doi: 10.1016/j.ejmech.2021.114062. Epub 2021 Dec 21. Eur J Med Chem. 2022. PMID: 34954592 Review.
Recent years have witnessed an explosive increase in the development of DYRK1A inhibitors. A variety of novel DYRK1A inhibitors have been reported as potential treatments for human diseases. In this review, the latest therapeutic potential of DYRK1A for diffe …
Recent years have witnessed an explosive increase in the development of DYRK1A inhibitors. A variety of novel DYRK1A inhibitor …
DYRK1A Syndrome.
van Bon BWM, Coe BP, de Vries BBA, Eichler EE. van Bon BWM, et al. 2015 Dec 17 [updated 2021 Mar 18]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2015 Dec 17 [updated 2021 Mar 18]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 26677511 Free Books & Documents. Review.
Ophthalmologic, urogenital, cardiac, and/or dental anomalies have been reported. DIAGNOSIS/TESTING: The diagnosis of DYRK1A syndrome is established in a proband with suggestive findings and a heterozygous pathogenic variant in DYRK1A identified by molecular genetic …
Ophthalmologic, urogenital, cardiac, and/or dental anomalies have been reported. DIAGNOSIS/TESTING: The diagnosis of DYRK1A syndrome …
Function and inhibition of DYRK1A: Emerging roles of treating multiple human diseases.
Yang Y, Fan X, Liu Y, Ye D, Liu C, Yang H, Su Z, Zhang Y, Liu Y. Yang Y, et al. Biochem Pharmacol. 2023 Jun;212:115521. doi: 10.1016/j.bcp.2023.115521. Epub 2023 Mar 28. Biochem Pharmacol. 2023. PMID: 36990324 Review.
It has been shown that it participates in the development of plenty of diseases, and both the low or high expression of DYRK1A protein could lead to disorder. Thus, DYRK1A is recognized as a key target for the therapy for these diseases, and the studies on natural o …
It has been shown that it participates in the development of plenty of diseases, and both the low or high expression of DYRK1A protei …
DYRK1A and cognition: A lifelong relationship.
Arbones ML, Thomazeau A, Nakano-Kobayashi A, Hagiwara M, Delabar JM. Arbones ML, et al. Pharmacol Ther. 2019 Feb;194:199-221. doi: 10.1016/j.pharmthera.2018.09.010. Epub 2018 Sep 28. Pharmacol Ther. 2019. PMID: 30268771 Review.
The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system (CNS) during development and aging. ...Because this kinase is positioned at the crossroads of many important processes, genetic dosage errors in this protein produce devastating effe …
The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system (CNS) during development and aging. ...Bec …
DYRK1A retinopathy.
Cai L, Wakabayashi T, Yonekawa Y, Wasserman BN. Cai L, et al. J AAPOS. 2023 Apr;27(2):107-110. doi: 10.1016/j.jaapos.2022.12.002. Epub 2023 Feb 1. J AAPOS. 2023. PMID: 36736451
We present a case of retinopathy in a 4-year-old girl with DYRK1A syndrome. On external examination, she had short stature, cognitive delay, microcephaly, and iris coloboma of the right eye. ...
We present a case of retinopathy in a 4-year-old girl with DYRK1A syndrome. On external examination, she had short stature, cognitive …
Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte cell cycle activation and cardiac repair after myocardial infarction.
Lan C, Chen C, Qu S, Cao N, Luo H, Yu C, Wang N, Xue Y, Xia X, Fan C, Ren H, Yang Y, Jose PA, Xu Z, Wu G, Zeng C. Lan C, et al. EBioMedicine. 2022 Aug;82:104139. doi: 10.1016/j.ebiom.2022.104139. Epub 2022 Jul 8. EBioMedicine. 2022. PMID: 35810562 Free PMC article.
This study explored the role and mechanism of dual-specificity tyrosine regulated kinase 1A (DYRK1A) in regulating cardiomyocyte cell cycle activation and cardiac repair after myocardial infarction (MI). METHODS: DYRK1A-knockout mice and DYRK1A inhibitors wer …
This study explored the role and mechanism of dual-specificity tyrosine regulated kinase 1A (DYRK1A) in regulating cardiomyocyte cell …
DYRK1A Inhibitors and Perspectives for the Treatment of Alzheimer's Disease.
de Souza MM, Cenci AR, Teixeira KF, Machado V, Mendes Schuler MCG, Gonçalves AE, Paula Dalmagro A, André Cazarin C, Gomes Ferreira LL, de Oliveira AS, Andricopulo AD. de Souza MM, et al. Curr Med Chem. 2023;30(6):669-688. doi: 10.2174/0929867329666220620162018. Curr Med Chem. 2023. PMID: 35726411 Review.
OBJECTIVE: In this review, we investigate the contribution of DYRK1A inhibitors as potential anti-AD agents. METHODS: A search in the literature to compile an in vitro dataset including IC50 values involving DYRK1A was performed from 2014 to the present day. ...CONC …
OBJECTIVE: In this review, we investigate the contribution of DYRK1A inhibitors as potential anti-AD agents. METHODS: A search in the …
The Omnipresence of DYRK1A in Human Diseases.
Deboever E, Fistrovich A, Hulme C, Dunckley T. Deboever E, et al. Int J Mol Sci. 2022 Aug 19;23(16):9355. doi: 10.3390/ijms23169355. Int J Mol Sci. 2022. PMID: 36012629 Free PMC article. Review.
The dual-specificity tyrosine-regulated kinase (DYRKs) family is of particular interest and, among them, DYRK1A has been implicated ubiquitously in varied human diseases. Herein, we focus on the characteristics of DYRK1A, its regulation and functional role in differ …
The dual-specificity tyrosine-regulated kinase (DYRKs) family is of particular interest and, among them, DYRK1A has been implicated u …
DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner.
Strine MS, Cai WL, Wei J, Alfajaro MM, Filler RB, Biering SB, Sarnik S, Chow RD, Patil A, Cervantes KS, Collings CK, DeWeirdt PC, Hanna RE, Schofield K, Hulme C, Konermann S, Doench JG, Hsu PD, Kadoch C, Yan Q, Wilen CB. Strine MS, et al. PLoS Biol. 2023 Jun 13;21(6):e3002097. doi: 10.1371/journal.pbio.3002097. eCollection 2023 Jun. PLoS Biol. 2023. PMID: 37310920 Free PMC article.
We show that DYRK1A promotes DNA accessibility at the ACE2 promoter and a putative distal enhancer, facilitating transcription and gene expression. Finally, we validate that the proviral activity of DYRK1A is conserved across species using cells of nonhuman primate …
We show that DYRK1A promotes DNA accessibility at the ACE2 promoter and a putative distal enhancer, facilitating transcription and ge …
DYRK1A Inhibitors as Potential Therapeutics for beta-Cell Regeneration for Diabetes.
Kumar K, Suebsuwong C, Wang P, Garcia-Ocana A, Stewart AF, DeVita RJ. Kumar K, et al. J Med Chem. 2021 Mar 25;64(6):2901-2922. doi: 10.1021/acs.jmedchem.0c02050. Epub 2021 Mar 8. J Med Chem. 2021. PMID: 33682417 Review.
In this context, regeneration of functional insulin-producing human beta-cells in people with diabetes through the use of DYRK1A inhibitor drugs has recently received special attention. Several small molecule DYRK1A inhibitors have been identified that induce human …
In this context, regeneration of functional insulin-producing human beta-cells in people with diabetes through the use of DYRK1A inhi …
925 results