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254 results

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Increased expression of ECT2 predicts the poor prognosis of breast cancer patients.
Yi M, Zhang D, Song B, Zhao B, Niu M, Wu Y, Dai Z, Wu K. Yi M, et al. Exp Hematol Oncol. 2022 Dec 26;11(1):107. doi: 10.1186/s40164-022-00361-3. Exp Hematol Oncol. 2022. PMID: 36572949 Free PMC article.
Integration analysis using public databases and tissue microarray indicated that high ECT2 was an adverse prognostic factor for breast cancer patients. ...Furthermore, ECT2 would be a novel target for drug development for breast cancer....
Integration analysis using public databases and tissue microarray indicated that high ECT2 was an adverse prognostic factor for breas …
Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth.
Cook DR, Kang M, Martin TD, Galanko JA, Loeza GH, Trembath DG, Justilien V, Pickering KA, Vincent DF, Jarosch A, Jurmeister P, Waters AM, Hibshman PS, Campbell AD, Ford CA, Keku TO, Yeh JJ, Lee MS, Cox AD, Fields AP, Sandler RS, Sansom OJ, Sers C, Schaefer A, Der CJ. Cook DR, et al. Cancer Res. 2022 Jan 1;82(1):90-104. doi: 10.1158/0008-5472.CAN-20-4218. Epub 2021 Nov 4. Cancer Res. 2022. PMID: 34737214 Free PMC article.
However, oncogenic activation of ECT2 resulted from N-terminal truncation, and such truncated ECT2 proteins have not been found in patients with cancer. ...Depletion of ECT2 reduced anchorage-independent cancer cell growth and invasion independe …
However, oncogenic activation of ECT2 resulted from N-terminal truncation, and such truncated ECT2 proteins have not been foun …
Effect of Ect2 Expression on the Growth of Triple-Negative Breast Cancer Cells with Paclitaxel Intervention.
Wang H, Liu H, Li J, Wei S, Liu X, Wan H, Zheng P, Zheng H. Wang H, et al. Onco Targets Ther. 2020 Dec 16;13:12905-12918. doi: 10.2147/OTT.S275725. eCollection 2020. Onco Targets Ther. 2020. PMID: 33376345 Free PMC article.
OBJECT: To identify the expression levels of ECT2 (epithelial cell transforming sequence 2) in triple-negative breast cancer (TNBC) before and after administration of paclitaxel (PTX) and explore the interaction between ECT2 and PTX in breast cancer tr …
OBJECT: To identify the expression levels of ECT2 (epithelial cell transforming sequence 2) in triple-negative breast cancer ( …
RACGAP1 modulates ECT2-Dependent mitochondrial quality control to drive breast cancer metastasis.
Ren K, Zhou D, Wang M, Li E, Hou C, Su Y, Zou Q, Zhou P, Liu X. Ren K, et al. Exp Cell Res. 2021 Mar 1;400(1):112493. doi: 10.1016/j.yexcr.2021.112493. Epub 2021 Jan 22. Exp Cell Res. 2021. PMID: 33485843
Most cancer deaths are due to the colonization of tumor cells in distant organs. ...Here we found that RACGAP1 promoted breast cancer metastasis through regulating mitochondrial quality control. ...
Most cancer deaths are due to the colonization of tumor cells in distant organs. ...Here we found that RACGAP1 promoted breast can …
FoxM1 insufficiency hyperactivates Ect2-RhoA-mDia1 signaling to drive cancer.
Limzerwala JF, Jeganathan KB, Kloeber JA, Davies BA, Zhang C, Sturmlechner I, Zhong J, Fierro Velasco R, Fields AP, Yuan Y, Baker DJ, Zhou D, Li H, Katzmann DJ, van Deursen JM. Limzerwala JF, et al. Nat Cancer. 2020 Oct;1(10):1010-1024. doi: 10.1038/s43018-020-00116-1. Epub 2020 Oct 12. Nat Cancer. 2020. PMID: 34841254 Free PMC article.
FoxM1 activates genes that regulate S-G2-M cell-cycle progression and, when overexpressed, is associated with poor clinical outcome in multiple cancers. Here we identify FoxM1 as a tumor suppressor in mice that, through its N-terminal domain, binds to and inhibits Ect2 …
FoxM1 activates genes that regulate S-G2-M cell-cycle progression and, when overexpressed, is associated with poor clinical outcome in multi …
Overexpression of ECT2 is a strong poor prognostic factor in ER(+) breast cancer.
Xiu Y, Liu W, Wang T, Liu Y, Ha M. Xiu Y, et al. Mol Clin Oncol. 2019 May;10(5):497-505. doi: 10.3892/mco.2019.1832. Epub 2019 Mar 20. Mol Clin Oncol. 2019. PMID: 30967944 Free PMC article.
ECT2 mRNA expression was significantly different in oestrogen receptor ER(+) breast cancer; overexpression of ECT2 was associated with poor prognosis in ER(+) breast cancer. The mRNA expression levels of ECT2 were increased in basal-like breast …
ECT2 mRNA expression was significantly different in oestrogen receptor ER(+) breast cancer; overexpression of ECT2 was …
Expression and prognostic significance of ECT2 in invasive breast cancer.
Wang HK, Liang JF, Zheng HX, Xiao H. Wang HK, et al. J Clin Pathol. 2018 May;71(5):442-445. doi: 10.1136/jclinpath-2017-204569. Epub 2017 Oct 19. J Clin Pathol. 2018. PMID: 29051317
METHODS: ECT2 immunohistochemical detection was performed in 165 breast cancer specimens and 100 normal control tissues. ...ECT2 could also be a potential molecular target for designing therapeutic strategies for breast cancer....
METHODS: ECT2 immunohistochemical detection was performed in 165 breast cancer specimens and 100 normal control tissues. ... …
Integrated Analysis of ECT2 and COL17A1 as Potential Biomarkers for Pancreatic Cancer.
Huang WL, Wu SF, Huang X, Zhou S. Huang WL, et al. Dis Markers. 2022 Jun 8;2022:9453549. doi: 10.1155/2022/9453549. eCollection 2022. Dis Markers. 2022. PMID: 35722628 Free PMC article.
The mRNA expression of ECT2 and COL17A1 was associated with DNA methylation and CNV. The cell cycle, proteasome, and pathways in cancer were enriched in the high-COL17A1 and ECT2 groups. The TME results showed that immune scores were decreased in the high- …
The mRNA expression of ECT2 and COL17A1 was associated with DNA methylation and CNV. The cell cycle, proteasome, and pathways in c …
Upregulation of ECT2 is associated with transcriptional program of cancer stem cells and predicts poor clinical outcome in gastric cancer.
Gong DY, Chen X, Yang TL, Wang Y, Guo Y, Zeng JH, Chen SZ. Gong DY, et al. Oncol Lett. 2020 Oct;20(4):54. doi: 10.3892/ol.2020.11915. Epub 2020 Jul 27. Oncol Lett. 2020. PMID: 32788941 Free PMC article.
The aim of the present study was to determine the involvement of epithelial cell transforming 2 (ECT2) in gastric cancer. The results of the present study demonstrated that ECT2 expression was upregulated in human gastric cancer samples. ...Characteriz …
The aim of the present study was to determine the involvement of epithelial cell transforming 2 (ECT2) in gastric cancer. The …
Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma.
Chaisaingmongkol J, Budhu A, Dang H, Rabibhadana S, Pupacdi B, Kwon SM, Forgues M, Pomyen Y, Bhudhisawasdi V, Lertprasertsuke N, Chotirosniramit A, Pairojkul C, Auewarakul CU, Sricharunrat T, Phornphutkul K, Sangrajrang S, Cam M, He P, Hewitt SM, Ylaya K, Wu X, Andersen JB, Thorgeirsson SS, Waterfall JJ, Zhu YJ, Walling J, Stevenson HS, Edelman D, Meltzer PS, Loffredo CA, Hama N, Shibata T, Wiltrout RH, Harris CC, Mahidol C, Ruchirawat M, Wang XW; TIGER-LC Consortium. Chaisaingmongkol J, et al. Cancer Cell. 2017 Jul 10;32(1):57-70.e3. doi: 10.1016/j.ccell.2017.05.009. Epub 2017 Jun 22. Cancer Cell. 2017. PMID: 28648284 Free PMC article.
Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are clinically disparate primary liver cancers with etiological and biological heterogeneity. We identified common molecular subtypes linked to similar prognosis among 199 Thai ICC and HCC patients th …
Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are clinically disparate primary liver cancers with etiologi …
254 results