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2013 2
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High RIG-I and EFTUD2 expression predicts poor survival in endometrial cancer.
Beyer S, Müller L, Mitter S, Keilmann L, Meister S, Buschmann C, Kraus F, Topalov NE, Czogalla B, Trillsch F, Burges A, Mahner S, Schmoeckel E, Löb S, Corradini S, Kessler M, Jeschke U, Kolben T. Beyer S, et al. J Cancer Res Clin Oncol. 2023 Jul;149(8):4293-4303. doi: 10.1007/s00432-022-04271-z. Epub 2022 Sep 7. J Cancer Res Clin Oncol. 2023. PMID: 36068443 Free PMC article.
For endometrial cancer, an immunogenic cancer, data about RIG-I and EFTUD2 are still missing. The aim of this study was to examine the expression of RIG-I and EFTUD2 in endometrial cancer. METHODS: 225 specimen of endometrial cancer were …
For endometrial cancer, an immunogenic cancer, data about RIG-I and EFTUD2 are still missing. The aim of this study was …
The feedback loop of EFTUD2/c-MYC impedes chemotherapeutic efficacy by enhancing EFTUD2 transcription and stabilizing c-MYC protein in colorectal cancer.
Zhu X, Li C, Gao Y, Zhang Q, Wang T, Zhou H, Bu F, Chen J, Mao X, He Y, Wu K, Li N, Luo H. Zhu X, et al. J Exp Clin Cancer Res. 2024 Jan 2;43(1):7. doi: 10.1186/s13046-023-02873-0. J Exp Clin Cancer Res. 2024. PMID: 38163859 Free PMC article.
Elongation factor Tu GTP binding domain containing 2 (EFTUD2) has emerged as a potential oncogenic factor implicated in various cancer types, where it fosters tumor growth and survival. ...We also demonstrated both in vitro and in vivo that knockdown of EFTUD2 …
Elongation factor Tu GTP binding domain containing 2 (EFTUD2) has emerged as a potential oncogenic factor implicated in various ca …
Over-activation of EFTUD2 correlates with tumor propagation and poor survival outcomes in hepatocellular carcinoma.
Lv C, Li XJ, Hao LX, Zhang S, Song Z, Ji XD, Gong B. Lv C, et al. Clin Transl Oncol. 2022 Jan;24(1):93-103. doi: 10.1007/s12094-021-02673-y. Epub 2021 Jul 19. Clin Transl Oncol. 2022. PMID: 34282556
The mechanism of EFTUD2 on carcinogenesis and development of liver cancer still need further study. ...Western blotting and quantitative PCR assays were used to verify the EFTUD2 expression in HCC cell lines and tumor tissues of liver cancer patients. …
The mechanism of EFTUD2 on carcinogenesis and development of liver cancer still need further study. ...Western blotting and qu …
EFTUD2 maintains the survival of tumor cells and promotes hepatocellular carcinoma progression via the activation of STAT3.
Tu M, He L, You Y, Li J, Yao N, Qu C, Huang W, Xu L, Luo R, Hong J. Tu M, et al. Cell Death Dis. 2020 Oct 6;11(10):830. doi: 10.1038/s41419-020-03040-5. Cell Death Dis. 2020. PMID: 33024090 Free PMC article.
It has been reported that EFTUD2 is a new host factor with activity against HCV infection. However, the role of EFTUD2 in solid tumors, including hepatocellular carcinoma (HCC), remains unexplored. In this study, we investigated the molecular function of EFTUD2 …
It has been reported that EFTUD2 is a new host factor with activity against HCV infection. However, the role of EFTUD2 in soli …
Mutation in Eftud2 causes craniofacial defects in mice via mis-splicing of Mdm2 and increased P53.
Beauchamp MC, Djedid A, Bareke E, Merkuri F, Aber R, Tam AS, Lines MA, Boycott KM, Stirling PC, Fish JL, Majewski J, Jerome-Majewska LA. Beauchamp MC, et al. Hum Mol Genet. 2021 May 28;30(9):739-757. doi: 10.1093/hmg/ddab051. Hum Mol Genet. 2021. PMID: 33601405 Free PMC article.
EFTUD2 is mutated in patients with mandibulofacial dysostosis with microcephaly (MFDM). We generated a mutant mouse line with conditional mutation in Eftud2 and used Wnt1-Cre2 to delete it in neural crest cells. Homozygous deletion of Eftud2 causes brain and …
EFTUD2 is mutated in patients with mandibulofacial dysostosis with microcephaly (MFDM). We generated a mutant mouse line with conditi …
Spliceosome protein Eftud2 promotes colitis-associated tumorigenesis by modulating inflammatory response of macrophage.
Lv Z, Wang Z, Luo L, Chen Y, Han G, Wang R, Xiao H, Li X, Hou C, Feng J, Shen B, Wang Y, Peng H, Guo R, Li Y, Chen G. Lv Z, et al. Mucosal Immunol. 2019 Sep;12(5):1164-1173. doi: 10.1038/s41385-019-0184-y. Epub 2019 Jul 5. Mucosal Immunol. 2019. PMID: 31278373 Free article.
In this study, we investigate its involvement in the pathogenesis of colitis-associated cancer (CAC). Using an established mouse model of CAC, we show that Eftud2 is constantly overexpressed in the colonic tissues as well as infiltrating macrophages. ...Furthermore, …
In this study, we investigate its involvement in the pathogenesis of colitis-associated cancer (CAC). Using an established mouse mode …
Spliceosome protein EFTUD2 is upregulated in the trophoblast of spontaneous miscarriage and hydatidiform mole.
Löb S, Vattai A, Kuhn C, Schmoeckel E, Mahner S, Wöckel A, Kolben T, Szekeres-Bartho J, Jeschke U, Vilsmaier T. Löb S, et al. J Reprod Immunol. 2020 Aug;140:103149. doi: 10.1016/j.jri.2020.103149. Epub 2020 May 18. J Reprod Immunol. 2020. PMID: 32447180
EFTUD2 is known to modulate immune responses and mutation of the EFTUD2-gene lead to fetal malformation. ...In addition, hCG is positively correlated to EFTUD2 in mole pregnancy. The addition of hCG to chorioncarcinoma cell lines JEG-3 in vitro stimulated …
EFTUD2 is known to modulate immune responses and mutation of the EFTUD2-gene lead to fetal malformation. ...In addition, hCG i …
The Role of the U5 snRNP in Genetic Disorders and Cancer.
Wood KA, Eadsforth MA, Newman WG, O'Keefe RT. Wood KA, et al. Front Genet. 2021 Jan 28;12:636620. doi: 10.3389/fgene.2021.636620. eCollection 2021. Front Genet. 2021. PMID: 33584830 Free PMC article. Review.
Furthermore, recurrent somatic mutations or changes in the expression levels of a number of U5 snRNP proteins (PRPF6, PRPF8, EFTUD2, DDX23, and SNRNP40) have been associated with human cancers. ...Additionally, why variants in different, yet interacting, proteins ma …
Furthermore, recurrent somatic mutations or changes in the expression levels of a number of U5 snRNP proteins (PRPF6, PRPF8, EFTUD2, …
Novel potential urinary biomarkers for effective diagnosis and prognostic evaluation of high-grade bladder cancer.
Zhang ZG, Shi ZD, Dong JJ, Chen YA, Cao MY, Li YT, Ma WM, Hao L, Pang K, Zhou JH, Zhang WD, Dong Y, Han CH. Zhang ZG, et al. Transl Cancer Res. 2023 Aug 31;12(8):1992-2007. doi: 10.21037/tcr-23-98. Epub 2023 Aug 28. Transl Cancer Res. 2023. PMID: 37701108 Free PMC article.
BACKGROUND: High-grade bladder cancer (HGBC) has a higher malignant potential, recurrence and progression rate compared to low-grade phenotype. ...Among them, DKC1 and SNRPG had the most prominent comprehensive values, and EFTUD2, LOR and EBNA1BP2 were relevant to a …
BACKGROUND: High-grade bladder cancer (HGBC) has a higher malignant potential, recurrence and progression rate compared to low-grade …
The Pregnancy Zone Protein (PZP) is significantly downregulated in the placenta of preeclampsia and HELLP syndrome patients.
Löb S, Vattai A, Kuhn C, Mittelberger J, Herbert SL, Wöckel A, Schmoeckel E, Mahner S, Jeschke U. Löb S, et al. J Reprod Immunol. 2022 Sep;153:103663. doi: 10.1016/j.jri.2022.103663. Epub 2022 Jul 9. J Reprod Immunol. 2022. PMID: 35843132
The expression of EFTUD2 was significantly lower in preeclampsia (ST: p = 0.003, EVT: p 0.001), HELLP syndrome (ST: p = 0.021, EVT: = 0.001, EVT: p = 0.001). ...Our results indicate that PZP and EFTUD2 might be involved in the development of placental dysfunction in …
The expression of EFTUD2 was significantly lower in preeclampsia (ST: p = 0.003, EVT: p 0.001), HELLP syndrome (ST: p = 0.021, EVT: = …
28 results