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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
2002 1
2004 1
2005 3
2006 3
2007 1
2008 2
2009 3
2010 4
2011 2
2012 7
2013 9
2014 6
2015 15
2016 9
2017 8
2018 9
2019 14
2020 9
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2022 13
2023 3
2024 3

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124 results

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Page 1
How autophagy controls the intestinal epithelial barrier.
Foerster EG, Mukherjee T, Cabral-Fernandes L, Rocha JDB, Girardin SE, Philpott DJ. Foerster EG, et al. Autophagy. 2022 Jan;18(1):86-103. doi: 10.1080/15548627.2021.1909406. Epub 2021 Apr 27. Autophagy. 2022. PMID: 33906557 Free PMC article. Review.
Here, we review the physiological role of autophagy in the context of intestinal epithelial maintenance and how genetic mutations affecting autophagy contribute to the development of intestinal disease.Abbreviations: AKT1S1: AKT1 substrate 1; AMBRA1: autophagy and beclin 1 regula …
Here, we review the physiological role of autophagy in the context of intestinal epithelial maintenance and how genetic mutations affecting …
DNA damage induces p53-independent apoptosis through ribosome stalling.
Boon NJ, Oliveira RA, Körner PR, Kochavi A, Mertens S, Malka Y, Voogd R, van der Horst SEM, Huismans MA, Smabers LP, Draper JM, Wessels LFA, Haahr P, Roodhart JML, Schumacher TNM, Snippert HJ, Agami R, Brummelkamp TR. Boon NJ, et al. Science. 2024 May 17;384(6697):785-792. doi: 10.1126/science.adh7950. Epub 2024 May 16. Science. 2024. PMID: 38753784
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine.
Yu D, Richardson NE, Green CL, Spicer AB, Murphy ME, Flores V, Jang C, Kasza I, Nikodemova M, Wakai MH, Tomasiewicz JL, Yang SE, Miller BR, Pak HH, Brinkman JA, Rojas JM, Quinn WJ 3rd, Cheng EP, Konon EN, Haider LR, Finke M, Sonsalla M, Alexander CM, Rabinowitz JD, Baur JA, Malecki KC, Lamming DW. Yu D, et al. Cell Metab. 2021 May 4;33(5):905-922.e6. doi: 10.1016/j.cmet.2021.03.025. Epub 2021 Apr 21. Cell Metab. 2021. PMID: 33887198 Free PMC article.
GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis.
Cordova RA, Misra J, Amin PH, Klunk AJ, Damayanti NP, Carlson KR, Elmendorf AJ, Kim HG, Mirek ET, Elzey BD, Miller MJ, Dong XC, Cheng L, Anthony TG, Pili R, Wek RC, Staschke KA. Cordova RA, et al. Elife. 2022 Sep 15;11:e81083. doi: 10.7554/eLife.81083. Elife. 2022. PMID: 36107759 Free PMC article.
A stress adaptation pathway termed the integrated stress response has been suggested to be active in many cancers including prostate cancer (PCa). Here, we demonstrate that the eIF2 kinase GCN2 is required for sustained growth in androgen-sensitive and castration-re …
A stress adaptation pathway termed the integrated stress response has been suggested to be active in many cancers including prostate …
GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment.
Halaby MJ, Hezaveh K, Lamorte S, Ciudad MT, Kloetgen A, MacLeod BL, Guo M, Chakravarthy A, Medina TDS, Ugel S, Tsirigos A, Bronte V, Munn DH, Pugh TJ, De Carvalho DD, Butler MO, Ohashi PS, Brooks DG, McGaha TL. Halaby MJ, et al. Sci Immunol. 2019 Dec 13;4(42):eaax8189. doi: 10.1126/sciimmunol.aax8189. Sci Immunol. 2019. PMID: 31836669 Free PMC article.
Reciprocal regulation between GCN2 (eIF2AK4) and PERK (eIF2AK3) through the JNK-FOXO3 axis to modulate cancer drug resistance and clonal survival.
Alasiri G, Jiramongkol Y, Trakansuebkul S, Ke HL, Mahmud Z, Intuyod K, Lam EW. Alasiri G, et al. Mol Cell Endocrinol. 2020 Sep 15;515:110932. doi: 10.1016/j.mce.2020.110932. Epub 2020 Jun 30. Mol Cell Endocrinol. 2020. PMID: 32615282 Free PMC article.
To explore the potential mechanisms involved, we performed time-course drug treatment experiments on the parental MCF-7 and drug resistant MCF-7Epi(R) and MCF-7Tax(R) breast cancer cells and identified GCN2 (eIF2AK4) as a molecule that can potentially cooperate with …
To explore the potential mechanisms involved, we performed time-course drug treatment experiments on the parental MCF-7 and drug resistant M …
IDO1: An important immunotherapy target in cancer treatment.
Li F, Zhang R, Li S, Liu J. Li F, et al. Int Immunopharmacol. 2017 Jun;47:70-77. doi: 10.1016/j.intimp.2017.03.024. Epub 2017 Mar 30. Int Immunopharmacol. 2017. PMID: 28365507 Review.
IDO1 can be induced in most human cells, especially APCs and cancer cells through canonical and non-canonical NF-kappaB and Jak/STAT pathways, as well as PKC and TGF-beta signaling pathways. A series of human cancers over-express IDO1 in a constitutive way. Thus, ID …
IDO1 can be induced in most human cells, especially APCs and cancer cells through canonical and non-canonical NF-kappaB and Jak/STAT …
Five endometrial cancer risk loci identified through genome-wide association analysis.
Cheng TH, Thompson DJ, O'Mara TA, Painter JN, Glubb DM, Flach S, Lewis A, French JD, Freeman-Mills L, Church D, Gorman M, Martin L; National Study of Endometrial Cancer Genetics Group (NSECG); Hodgson S, Webb PM; Australian National Endometrial Cancer Study Group (ANECS); Attia J, Holliday EG, McEvoy M, Scott RJ, Henders AK, Martin NG, Montgomery GW, Nyholt DR, Ahmed S, Healey CS, Shah M, Dennis J, Fasching PA, Beckmann MW, Hein A, Ekici AB, Hall P, Czene K, Darabi H, Li J, Dörk T, Dürst M, Hillemanns P, Runnebaum I, Amant F, Schrauwen S, Zhao H, Lambrechts D, Depreeuw J, Dowdy SC, Goode EL, Fridley BL, Winham SJ, Njølstad TS, Salvesen HB, Trovik J, Werner HM, Ashton K, Otton G, Proietto T, Liu T, Mints M, Tham E; RENDOCAS; Consortium C, Jun Li M, Yip SH, Wang J, Bolla MK, Michailidou K, Wang Q, Tyrer JP, Dunlop M, Houlston R, Palles C, Hopper JL; AOCS Group; Peto J, Swerdlow AJ, Burwinkel B, Brenner H, Meindl A, Brauch H, Lindblom A, Chang-Claude J, Couch FJ, Giles GG, Kristensen VN, Cox A, Cunningham JM, Pharoah PDP, Dunning AM, Edwards SL, Easton DF, Tomlinson I, Spurdle AB. Cheng TH, et al. Nat Genet. 2016 Jun;48(6):667-674. doi: 10.1038/ng.3562. Epub 2016 May 2. Nat Genet. 2016. PMID: 27135401 Free PMC article.
We conducted a meta-analysis of three endometrial cancer genome-wide association studies (GWAS) and two follow-up phases totaling 7,737 endometrial cancer cases and 37,144 controls of European ancestry. ...These findings provide enhanced insight into the genetic and …
We conducted a meta-analysis of three endometrial cancer genome-wide association studies (GWAS) and two follow-up phases totaling 7,7 …
124 results