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Page 1
The Bad, the Good and eIF3e/INT6.
Sesen J, Casaos J, Scotland SJ, Seva C, Eisinger-Mathason TS, Skuli N. Sesen J, et al. Front Biosci (Landmark Ed). 2017 Jan 1;22(1):1-20. doi: 10.2741/4469. Front Biosci (Landmark Ed). 2017. PMID: 27814599 Free article. Review.
Interestingly, INT6/eIF3e is a double-edged sword that has both oncogenic and tumor suppressive abilities. ...Although a deeper understanding of the molecular mechanisms involved in these pathophysiological functions is essential, particularly to transform the in vitro/in …
Interestingly, INT6/eIF3e is a double-edged sword that has both oncogenic and tumor suppressive abilities. ...Although a deeper under …
INT6/eIF3e represses E-cadherin expression through HIF2alpha in lung carcinoma A549 cells.
Gotoh-Saito S, Sadato D, Shibasaki F. Gotoh-Saito S, et al. Genes Cells. 2022 Dec;27(12):689-705. doi: 10.1111/gtc.12984. Epub 2022 Sep 29. Genes Cells. 2022. PMID: 36116043 Free article.
Presently, the downstream targets for INT6/eIF3e-regulated HIF2alpha are unknown. Given the roles of HIF2alpha and INT6/eIF3e in epithelial-mesenchymal transition (EMT) that promotes cancer metastasis, we hypothesized that INT6/eIF3e-regulated HIF2alph …
Presently, the downstream targets for INT6/eIF3e-regulated HIF2alpha are unknown. Given the roles of HIF2alpha and INT6/eIF3e …
Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1.
Morris C, Durand S, Jalinot P. Morris C, et al. Oncotarget. 2021 Mar 30;12(7):649-664. doi: 10.18632/oncotarget.27923. eCollection 2021 Mar 30. Oncotarget. 2021. PMID: 33868586 Free PMC article.
Altered expression of the translation factor eIF3e is associated with breast cancer occurrence. We have previously shown that eIF3e deficiency leads to an impaired DNA damage response with a marked decrease in DNA repair by homologous recombination. ...This s …
Altered expression of the translation factor eIF3e is associated with breast cancer occurrence. We have previously shown that …
Genetic etiology of oral cancer.
Ali J, Sabiha B, Jan HU, Haider SA, Khan AA, Ali SS. Ali J, et al. Oral Oncol. 2017 Jul;70:23-28. doi: 10.1016/j.oraloncology.2017.05.004. Epub 2017 May 17. Oral Oncol. 2017. PMID: 28622887 Review.
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. It accounts for 2.5% of all new cancer cases and 1.9% of all cancer deaths annually. ...This high incidence occurs in correlation with oral cancer-associated behav …
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. It accounts for 2.5% of all new cancer …
Overexpression of eIF3e is correlated with colon tumor development and poor prognosis.
Li Z, Lin S, Jiang T, Wang J, Lu H, Tang H, Teng M, Fan J. Li Z, et al. Int J Clin Exp Pathol. 2014 Sep 15;7(10):6462-74. eCollection 2014. Int J Clin Exp Pathol. 2014. PMID: 25400724 Free PMC article.
Translational control plays key roles in the complex mechanism of cancer development and progression. However, the clinical significance of eIF3e in colon cancer remains to be elucidated. ...Down-regulation of eIF3e in vitro inhibited colon cancer …
Translational control plays key roles in the complex mechanism of cancer development and progression. However, the clinical significa …
An oncogenic role of eIF3e/INT6 in human breast cancer.
Grzmil M, Rzymski T, Milani M, Harris AL, Capper RG, Saunders NJ, Salhan A, Ragoussis J, Norbury CJ. Grzmil M, et al. Oncogene. 2010 Jul 15;29(28):4080-9. doi: 10.1038/onc.2010.152. Epub 2010 May 10. Oncogene. 2010. PMID: 20453879
Analysis of protein synthesis after siRNA-mediated knockdown in breast cancer cell lines indicated that eIF3e is not required for bulk translation. ...Taken together, our study data suggest that eIF3e has a positive role in breast cancer progression. I …
Analysis of protein synthesis after siRNA-mediated knockdown in breast cancer cell lines indicated that eIF3e is not required …
Decreased eIF3e/Int6 expression causes epithelial-to-mesenchymal transition in breast epithelial cells.
Gillis LD, Lewis SM. Gillis LD, et al. Oncogene. 2013 Aug 1;32(31):3598-605. doi: 10.1038/onc.2012.371. Epub 2012 Aug 20. Oncogene. 2013. PMID: 22907435
These findings suggest that eIF3e/Int6 is a tumor suppressor; however, a recent study has reported that a reduction of eIF3e/Int6 expression in breast cancer cells leads to reduced translation of oncogenes, suggesting that eIF3e/Int6 may in fact have a …
These findings suggest that eIF3e/Int6 is a tumor suppressor; however, a recent study has reported that a reduction of eIF3e/I …
Decreased eIF3e Expression Can Mediate Epithelial-to-Mesenchymal Transition through Activation of the TGFbeta Signaling Pathway.
Desnoyers G, Frost LD, Courteau L, Wall ML, Lewis SM. Desnoyers G, et al. Mol Cancer Res. 2015 Oct;13(10):1421-30. doi: 10.1158/1541-7786.MCR-14-0645. Epub 2015 Jun 8. Mol Cancer Res. 2015. PMID: 26056130
Decreased eIF3e expression is often observed in breast and lung cancer and has been shown to induce epithelial-to-mesenchymal transition (EMT) in breast epithelial cells by an unknown mechanism. Here, we study the effect of decreased eIF3e expression in lung …
Decreased eIF3e expression is often observed in breast and lung cancer and has been shown to induce epithelial-to-mesenchymal …
Up-regulation Of EIF3e Is Associated with The Progression of Esophageal Squamous Cell Carcinoma and Poor Prognosis in Patients.
Xu F, Gu J, Wang L, Liu R, Yuan Y, Wang H, Jiang J, Mao W, Lu C, Ge D. Xu F, et al. J Cancer. 2018 Mar 8;9(7):1135-1144. doi: 10.7150/jca.22546. eCollection 2018. J Cancer. 2018. PMID: 29675094 Free PMC article.
Introduction: Esophageal cancer is one of the most common malignant tumors in the world. Eukaryotic translation initiation factors 3e (eIF3e) makes a notable difference in the initiation of protein synthesis and tumor progression. ...Results: Up-regulation of eIF …
Introduction: Esophageal cancer is one of the most common malignant tumors in the world. Eukaryotic translation initiation factors 3e …
RSPO fusion transcripts in colorectal cancer in Japanese population.
Shinmura K, Kahyo T, Kato H, Igarashi H, Matsuura S, Nakamura S, Kurachi K, Nakamura T, Ogawa H, Funai K, Tanahashi M, Niwa H, Sugimura H. Shinmura K, et al. Mol Biol Rep. 2014 Aug;41(8):5375-84. doi: 10.1007/s11033-014-3409-x. Epub 2014 May 22. Mol Biol Rep. 2014. PMID: 24847761
In this study, we examined 75 primary CRCs and 121 primary lung cancers in the Japanese population for EIF3E-RSPO2 and PTPRK-RSPO3 fusion transcripts using RT-PCR and subsequent sequencing analyses. ...Interestingly, in one of the two EIF3E-RSPO2 fusion-posit …
In this study, we examined 75 primary CRCs and 121 primary lung cancers in the Japanese population for EIF3E-RSPO2 and PTPRK-R …
51 results