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Page 1
Nuclear distribution of eIF3g and its interacting nuclear proteins in breast cancer cells.
Zheng Q, Liu H, Ye J, Zhang H, Jia Z, Cao J. Zheng Q, et al. Mol Med Rep. 2016 Apr;13(4):2973-80. doi: 10.3892/mmr.2016.4935. Epub 2016 Feb 23. Mol Med Rep. 2016. PMID: 26935993 Free PMC article.
It is also involved in caspase-mediated apoptosis, and is upregulated in multidrug-resistant cancer cells. In the present study, the nuclear distribution of eIF3g was determined by performing co-immunoprecipitation of proteins that potentially interact with eIF3g …
It is also involved in caspase-mediated apoptosis, and is upregulated in multidrug-resistant cancer cells. In the present study, the …
Long non-coding RNA LINC02446 suppresses the proliferation and metastasis of bladder cancer cells by binding with EIF3G and regulating the mTOR signalling pathway.
Zhang X, Zhang J, Zhao W, Dong X, Xin P, Liu X, Li X, Jing Z, Zhang Z, Kong C, Yu X. Zhang X, et al. Cancer Gene Ther. 2021 Dec;28(12):1376-1389. doi: 10.1038/s41417-020-00285-2. Epub 2021 Feb 2. Cancer Gene Ther. 2021. PMID: 33526846
In the present study, we used the TCGA and GEO databases and identified LINC02446 as associated with prognosis and differentially expressed in bladder cancer tissues and para-cancer tissues. Then, we found that LINC02446 could affect the proliferation, migration and …
In the present study, we used the TCGA and GEO databases and identified LINC02446 as associated with prognosis and differentially expressed …
Eukaryotic translation initiation factor 3 subunit G promotes human colorectal cancer.
Yang C, Zhang Y, Du W, Cheng H, Li C. Yang C, et al. Am J Transl Res. 2019 Feb 15;11(2):612-623. eCollection 2019. Am J Transl Res. 2019. PMID: 30899366 Free PMC article.
In this study, we investigated the role of eukaryotic translation initiation factor 3 subunit G (EIF3G) in colorectal cancer. Immunohistochemical analysis showed higher EIF3G expression in stage IV human colorectal cancer tissues than in adjacent norma …
In this study, we investigated the role of eukaryotic translation initiation factor 3 subunit G (EIF3G) in colorectal cancer. …
Eukaryotic translation initiation factor 3 subunit G (EIF3G) resensitized HCT116/5-Fu to 5-fluorouracil (5-Fu) via inhibition of MRP and MDR1.
Yang C, Liu X, Li C, Li S, Du W, Yang D. Yang C, et al. Onco Targets Ther. 2018 Aug 31;11:5315-5324. doi: 10.2147/OTT.S170854. eCollection 2018. Onco Targets Ther. 2018. PMID: 30214237 Free PMC article.
PURPOSE: Colorectal cancer (CRC) has become a predominant cancer and accounts for approximately 10% of cancer-related mortality. ...CONCLUSION: These findings demonstrate that EIF3G is a targetable regulator of chemoresistance in CRC, and inhibiting …
PURPOSE: Colorectal cancer (CRC) has become a predominant cancer and accounts for approximately 10% of cancer-related m …
Knockdown of RPL34 suppresses osteosarcoma cell proliferation likely through EIF3/FAU signaling pathway.
Huang P, Zhao J, Fowdur M, Liu Y, Wu H, He M. Huang P, et al. Transl Cancer Res. 2019 Jun;8(3):848-855. doi: 10.21037/tcr.2019.05.05. Transl Cancer Res. 2019. PMID: 35116824 Free PMC article.
BACKGROUND: This study aims to explore the effect of knockdown of the ribosomal protein L34 (RPL34) on osteosarcoma cell proliferation through EIF3/FAU. METHODS: The mRNA expression levels of RPL34, EIF3A, EIF3F, EIF3G, UBA52, UBC, and FAU were quantified using quantitativ …
BACKGROUND: This study aims to explore the effect of knockdown of the ribosomal protein L34 (RPL34) on osteosarcoma cell proliferation throu …
Spectrin domain of eukaryotic initiation factor 3a is the docking site for formation of the a:b:i:g subcomplex.
Dong Z, Qi J, Peng H, Liu J, Zhang JT. Dong Z, et al. J Biol Chem. 2013 Sep 27;288(39):27951-9. doi: 10.1074/jbc.M113.483164. Epub 2013 Aug 6. J Biol Chem. 2013. PMID: 23921387 Free PMC article.
eIF3a (eukaryotic translation initiation factor 3a), one of the core subunits of the eIF3 complex, has been implicated in regulating translation of different mRNAs and in tumorigenesis. A subcomplex consisting of eIF3a, eIF3b, eIF3g, and eIF3i (eIF3(a:b:i:g)) has also been …
eIF3a (eukaryotic translation initiation factor 3a), one of the core subunits of the eIF3 complex, has been implicated in regulating transla …
Suppression of CCT3 Inhibits Tumor Progression by Impairing ATP Production and Cytoplasmic Translation in Lung Adenocarcinoma.
Chen S, Tian Y, Ju A, Li B, Fu Y, Luo Y. Chen S, et al. Int J Mol Sci. 2022 Apr 2;23(7):3983. doi: 10.3390/ijms23073983. Int J Mol Sci. 2022. PMID: 35409343 Free PMC article.
Heat shock proteins are highly expressed in various cancers and exert critical functions in tumor progression. However, their expression patterns and functions in lung adenocarcinoma (LUAD) remain largely unknown. ...Impaired protein synthesis and cell growth in EIF3G …
Heat shock proteins are highly expressed in various cancers and exert critical functions in tumor progression. However, their express …
Hypodermal responses to protein synthesis inhibition induce systemic developmental arrest and AMPK-dependent survival in Caenorhabditis elegans.
Dalton HM, Curran SP. Dalton HM, et al. PLoS Genet. 2018 Jul 18;14(7):e1007520. doi: 10.1371/journal.pgen.1007520. eCollection 2018 Jul. PLoS Genet. 2018. PMID: 30020921 Free PMC article.
We inhibited protein synthesis by reducing ribosome biogenesis (rps-11/RPS11 RNAi), translation initiation (ifg-1/EIF3G mutation and egl-45/EIF3A RNAi), or ribosome progression (cycloheximide treatment), all of which result in a specific arrest at larval stage 2 of C. eleg …
We inhibited protein synthesis by reducing ribosome biogenesis (rps-11/RPS11 RNAi), translation initiation (ifg-1/EIF3G mutation and …
Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase.
Martineau Y, Wang X, Alain T, Petroulakis E, Shahbazian D, Fabre B, Bousquet-Dubouch MP, Monsarrat B, Pyronnet S, Sonenberg N. Martineau Y, et al. Mol Cell Biol. 2014 Mar;34(6):1046-53. doi: 10.1128/MCB.01079-13. Epub 2014 Jan 6. Mol Cell Biol. 2014. PMID: 24396066 Free PMC article.
We previously showed that the interaction of PABP-interacting protein 1 (Paip1) with PABP and eukaryotic translation initiation factor 3 (eIF3; via the eIF3g subunit) further stimulates translation. Here, we demonstrate that the interaction of eIF3 with Paip1 is regulated …
We previously showed that the interaction of PABP-interacting protein 1 (Paip1) with PABP and eukaryotic translation initiation factor 3 (eI …
The histone deacetylase inhibitor, Vorinostat, represses hypoxia inducible factor 1 alpha expression through translational inhibition.
Hutt DM, Roth DM, Vignaud H, Cullin C, Bouchecareilh M. Hutt DM, et al. PLoS One. 2014 Aug 28;9(8):e106224. doi: 10.1371/journal.pone.0106224. eCollection 2014. PLoS One. 2014. PMID: 25166596 Free PMC article.
Hypoxia inducible factor 1alpha (HIF-1alpha) is a master regulator of tumor angiogenesis being one of the major targets for cancer therapy. Previous studies have shown that Histone Deacetylase Inhibitors (HDACi) block tumor angiogenesis through the inhibition of HIF-1alpha …
Hypoxia inducible factor 1alpha (HIF-1alpha) is a master regulator of tumor angiogenesis being one of the major targets for cancer th …
11 results