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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 1
1994 3
1995 3
1996 4
1997 5
1998 8
1999 10
2000 6
2001 3
2002 9
2003 6
2004 5
2005 4
2006 4
2007 10
2008 8
2009 8
2010 5
2011 11
2012 9
2013 11
2014 10
2015 9
2016 11
2017 12
2018 13
2019 6
2020 10
2021 14
2022 10
2023 7
2024 3

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225 results

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Page 1
Schwann cell-derived extracellular vesicles promote memory impairment associated with chronic neuropathic pain.
Tang Y, Wu J, Liu C, Gan L, Chen H, Sun YL, Liu J, Tao YX, Zhu T, Chen C. Tang Y, et al. J Neuroinflammation. 2024 Apr 17;21(1):99. doi: 10.1186/s12974-024-03081-z. J Neuroinflammation. 2024. PMID: 38632655 Free PMC article.
Notably, during CCI stress, SC-EVs could be transferred into the brain through the circulation and accumulate in the hippocampal CA1-CA3 regions. miR-142-5p was the main cargo wrapped in SC-EVs and mediated the development of CCI-associated memory impairment. Furthermore, alpha-a …
Notably, during CCI stress, SC-EVs could be transferred into the brain through the circulation and accumulate in the hippocampal CA1-CA3 reg …
HuD (ELAVL4) gain-of-function impairs neuromuscular junctions and induces apoptosis in in vitro and in vivo models of amyotrophic lateral sclerosis.
Silvestri B, Mochi M, Mawrie D, de Turris V, Colantoni A, Borhy B, Medici M, Anderson EN, Garone MG, Zammerilla CP, Pandey UB, Rosa A. Silvestri B, et al. bioRxiv [Preprint]. 2024 Mar 1:2023.08.22.554258. doi: 10.1101/2023.08.22.554258. bioRxiv. 2024. PMID: 38464028 Free PMC article. Preprint.
By taking advantage of co-cultures of motoneurons and skeletal muscle derived from human induced pluripotent stem cells (iPSCs), we show that the neural RNA binding protein HuD (ELAVL4) may underlie NMJ defects and apoptosis in FUS-ALS. HuD overexpression in motoneurons ph …
By taking advantage of co-cultures of motoneurons and skeletal muscle derived from human induced pluripotent stem cells (iPSCs), we show tha …
Deciphering the Akt1-HuD interaction in HuD-mediated neuronal differentiation.
Nishisaka H, Tomohiro T, Fukuzumi K, Fukao A, Funakami Y, Fujiwara T. Nishisaka H, et al. Biochimie. 2024 Jan 18;221:20-26. doi: 10.1016/j.biochi.2024.01.010. Online ahead of print. Biochimie. 2024. PMID: 38244852
The RNA-binding protein HuD/ELAVL4 is essential for neuronal development and synaptic plasticity by governing various post-transcriptional processes of target mRNAs, including stability, translation, and localization. ...
The RNA-binding protein HuD/ELAVL4 is essential for neuronal development and synaptic plasticity by governing various post-transcript …
Long 3'UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation.
Dorrity TJ, Shin H, Wiegand KA, Aruda J, Closser M, Jung E, Gertie JA, Leone A, Polfer R, Culbertson B, Yu L, Wu C, Ito T, Huang Y, Steckelberg AL, Wichterle H, Chung H. Dorrity TJ, et al. Sci Immunol. 2023 Oct 27;8(88):eadg2979. doi: 10.1126/sciimmunol.adg2979. Epub 2023 Oct 20. Sci Immunol. 2023. PMID: 37862432 Free PMC article.
We found that the neuron-enriched ELAVL family of genes (ELAVL2, ELAVL3, and ELAVL4) can increase (i) 3'UTR length, (ii) dsRNA load, and (iii) activation of dsRNA-sensing PRRs such as MDA5, PKR, and TLR3. ...
We found that the neuron-enriched ELAVL family of genes (ELAVL2, ELAVL3, and ELAVL4) can increase (i) 3'UTR length, (ii) dsRNA load, …
MicroRNA-375 Is Induced during Astrocyte-to-Neuron Reprogramming and Promotes Survival of Reprogrammed Neurons when Overexpressed.
Chen X, Sokirniy I, Wang X, Jiang M, Mseis-Jackson N, Williams C, Mayes K, Jiang N, Puls B, Du Q, Shi Y, Li H. Chen X, et al. Cells. 2023 Sep 3;12(17):2202. doi: 10.3390/cells12172202. Cells. 2023. PMID: 37681934 Free PMC article.
Functionally, we showed that miR-375 overexpression improved NeuroD1-mediated reprogramming efficiency by promoting cell survival at early stages in HA and did not appear to compromise the maturation of the reprogrammed neurons. Lastly, overexpression of miR-375-refractory ELA …
Functionally, we showed that miR-375 overexpression improved NeuroD1-mediated reprogramming efficiency by promoting cell survival at early s …
ELAVL4 promotes the tumorigenesis of small cell lung cancer by stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2 activation.
Li S, Lv J, Zhang X, Zhang Q, Li Z, Lu J, Huo X, Guo M, Liu X, Gao R, Gong J, Li C, Li W, Zhang T, Wang J, Chen Z, Du X. Li S, et al. FASEB J. 2023 Oct;37(10):e23170. doi: 10.1096/fj.202300314RR. FASEB J. 2023. PMID: 37676718
Mechanistically, LYPLAL1-DT negatively regulates the expression of miR-204-5p, leading to the upregulation of PFN2, thus, promoting SCLC cell proliferation, migration, and invasion. ELAVL4 has been shown to enhance the stability of LYPLAL1-DT and PFN2 mRNA. Our study revea …
Mechanistically, LYPLAL1-DT negatively regulates the expression of miR-204-5p, leading to the upregulation of PFN2, thus, promoting SCLC cel …
MicroRNA-375 is induced during astrocyte-to-neuron reprogramming and promotes survival of reprogrammed neurons when overexpressed.
Chen X, Sokirniy I, Wang X, Jiang M, Mseis-Jackson N, Williams C, Mayes K, Jiang N, Puls B, Du Q, Shi Y, Li H. Chen X, et al. bioRxiv [Preprint]. 2023 Jul 11:2023.07.10.548401. doi: 10.1101/2023.07.10.548401. bioRxiv. 2023. PMID: 37503054 Free PMC article. Updated. Preprint.
Moreover, miR-375 overexpression doesn't appear to compromise maturation of the reprogrammed neurons in long term HA cultures. Lastly, overexpression of miR-375-refractory ELAVL4 induces apoptosis and reverses the cell survival-promoting effect of miR-375 during AtN reprog …
Moreover, miR-375 overexpression doesn't appear to compromise maturation of the reprogrammed neurons in long term HA cultures. Lastly, overe …
NCBP1 Improves Cognitive Function in Mice by Reducing Oxidative Stress, Neuronal Loss, and Glial Activation After Status Epilepticus.
Gao X, You Z, Huang C, Liu Z, Tan Z, Li J, Liu Y, Liu X, Wei F, Fan Z, Qi S, Sun J. Gao X, et al. Mol Neurobiol. 2023 Nov;60(11):6676-6688. doi: 10.1007/s12035-023-03497-3. Epub 2023 Jul 20. Mol Neurobiol. 2023. PMID: 37474884
Further study indicated that NCBP1 overexpression inhibited the expression of IL-6, IL-1beta, and IFN-gamma in serum and hippocampus as well as MDA and LDH in the hippocampus, whereas it increased the SOD levels, suggesting that overexpression of NCBP1 could diminish KA-induced i …
Further study indicated that NCBP1 overexpression inhibited the expression of IL-6, IL-1beta, and IFN-gamma in serum and hippocampus as well …
LncRNA34977 promotes the proliferation, migration, and invasion and inhibits the apoptosis of canine mammary tumors by regulating the expression of miR-8881/ELAVL4.
Lu B, Zhu Y, Wu J, Qiu H, Wang J, Ma Z, Jia K. Lu B, et al. Funct Integr Genomics. 2023 Jan 6;23(1):31. doi: 10.1007/s10142-022-00955-4. Funct Integr Genomics. 2023. PMID: 36604379 Free PMC article.
In the transfection with miR-8881 inhibitors, the result is the opposite. Co-transfected with lncRNA34977, miR-8881, or ELAVL4, we found that lncRNA34977 could regulate the expression of miR-8881 or ELAVL4. Our study shows that lncRNA34977 promotes the proliferation …
In the transfection with miR-8881 inhibitors, the result is the opposite. Co-transfected with lncRNA34977, miR-8881, or ELAVL4, we fo …
225 results