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83 results

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Page 1
ELAVL4 promotes the tumorigenesis of small cell lung cancer by stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2 activation.
Li S, Lv J, Zhang X, Zhang Q, Li Z, Lu J, Huo X, Guo M, Liu X, Gao R, Gong J, Li C, Li W, Zhang T, Wang J, Chen Z, Du X. Li S, et al. FASEB J. 2023 Oct;37(10):e23170. doi: 10.1096/fj.202300314RR. FASEB J. 2023. PMID: 37676718
Small cell lung cancer (SCLC) is one of the most malignant tumors that has an extremely poor prognosis. ...Our study reveals a regulatory pathway, where ELAVL4 stabilizes PFN2 and LYPLAL1-DT with the latter further increasing PFN2 expression by blocking the action o …
Small cell lung cancer (SCLC) is one of the most malignant tumors that has an extremely poor prognosis. ...Our study reveals a regula …
Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4.
Pulido MA, DerHartunian MK, Qin Z, Chung EM, Kang DS, Woodham AW, Tsou JA, Klooster R, Akbari O, Wang L, Kast WM, Liu SV, Verschuuren JJGM, Aswad DW, Laird-Offringa IA. Pulido MA, et al. J Neuroimmunol. 2016 Oct 15;299:70-78. doi: 10.1016/j.jneuroim.2016.09.002. Epub 2016 Sep 3. J Neuroimmunol. 2016. PMID: 27725125 Free PMC article.
Specifically, the N-terminal region of ELAVL4, previously implicated in SCLC-associated autoimmunity, undergoes isoaspartylation in vitro, is recognized by sera from anti-ELAVL4 positive SCLC patients and is highly immunogenic in subcutaneously injected mice and in …
Specifically, the N-terminal region of ELAVL4, previously implicated in SCLC-associated autoimmunity, undergoes isoaspartylation in v …
RNA-binding protein ELAVL4/HuD ameliorates Alzheimer's disease-related molecular changes in human iPSC-derived neurons.
van der Linden RJ, Gerritsen JS, Liao M, Widomska J, Pearse RV 2nd, White FM, Franke B, Young-Pearse TL, Poelmans G. van der Linden RJ, et al. Prog Neurobiol. 2022 Oct;217:102316. doi: 10.1016/j.pneurobio.2022.102316. Epub 2022 Jul 14. Prog Neurobiol. 2022. PMID: 35843356 Free PMC article.
We generated ELAVL4 knockout (KO) human induced pluripotent stem cell-derived neurons to study the effect that ELAVL4 has on AD-related cellular phenotypes. ...Overexpression of ELAVL4 in wild-type neurons and rescue experiments in ELAVL4 KO cells show …
We generated ELAVL4 knockout (KO) human induced pluripotent stem cell-derived neurons to study the effect that ELAVL4 has on A …
Application of Serum ELAVL4 (HuD) Antigen Assay for Small Cell Lung Cancer Diagnosis.
Wang F, Lu J, Li S, Huo X, Liu X, Du X, Li C, Wang J, Chen Z. Wang F, et al. Anticancer Res. 2017 Aug;37(8):4515-4522. doi: 10.21873/anticanres.11848. Anticancer Res. 2017. PMID: 28739747
BACKGROUND/AIM: The ELAVL4 (HuD) is a neuron-specific RNA-binding protein expressed in 100% of small cell lung cancer (SCLC) cells and over 50% of neuroblastoma cells. The aim of this study was to investigate the serum HuD concentration in SCLC patients and the poss …
BACKGROUND/AIM: The ELAVL4 (HuD) is a neuron-specific RNA-binding protein expressed in 100% of small cell lung cancer (SCLC) c …
Identification of ELAVL4 as a modulator of radiation sensitivity in A549 non-small cell lung cancer cells.
Choi KJ, Lee JH, Kim KS, Kang S, Lee YS, Bae S. Choi KJ, et al. Oncol Rep. 2011 Jul;26(1):55-63. doi: 10.3892/or.2011.1260. Epub 2011 Apr 13. Oncol Rep. 2011. PMID: 21491091
Cell viability assays such as clonogenic assay, MTT and FACS analysis of cell death, identified the ELAVL4 gene as a novel modulator of radiation sensitivity. ELAVL4 expression was induced following ionizing irradiation. ...Thus the endogenous function of ELAVL4 …
Cell viability assays such as clonogenic assay, MTT and FACS analysis of cell death, identified the ELAVL4 gene as a novel modulator …
Data on isoaspartylation of neuronal ELAVL proteins.
Pulido MA, DerHartunian MK, Sehgal P, Laird-Offringa IA. Pulido MA, et al. Data Brief. 2016 Nov 17;9:1052-1055. doi: 10.1016/j.dib.2016.11.034. eCollection 2016 Dec. Data Brief. 2016. PMID: 27924291 Free PMC article.
The data are related to the article "Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4" (M.A. ...Laird-Offringa, 2016) [1], in which it was reported that the N-terminal region of recombinant human E …
The data are related to the article "Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuro …
LncRNA34977 promotes the proliferation, migration, and invasion and inhibits the apoptosis of canine mammary tumors by regulating the expression of miR-8881/ELAVL4.
Lu B, Zhu Y, Wu J, Qiu H, Wang J, Ma Z, Jia K. Lu B, et al. Funct Integr Genomics. 2023 Jan 6;23(1):31. doi: 10.1007/s10142-022-00955-4. Funct Integr Genomics. 2023. PMID: 36604379 Free PMC article.
In the transfection with miR-8881 inhibitors, the result is the opposite. Co-transfected with lncRNA34977, miR-8881, or ELAVL4, we found that lncRNA34977 could regulate the expression of miR-8881 or ELAVL4. Our study shows that lncRNA34977 promotes the proliferation …
In the transfection with miR-8881 inhibitors, the result is the opposite. Co-transfected with lncRNA34977, miR-8881, or ELAVL4, we fo …
Glucose deprivation enhances resistance to paclitaxel via ELAVL2/4-mediated modification of glycolysis in ovarian cancer cells.
Park GB, Jeong JY, Choi S, Yoon YS, Kim D. Park GB, et al. Anticancer Drugs. 2022 Jan 1;33(1):e370-e380. doi: 10.1097/CAD.0000000000001215. Anticancer Drugs. 2022. PMID: 34419957
The dysregulation of glycolysis regardless of oxygen availability is one of the major characteristics of cancer cells. While the drug resistance of ovarian cancer cells has been extensively studied, the molecular mechanism of anticancer drug resistance under low-glu …
The dysregulation of glycolysis regardless of oxygen availability is one of the major characteristics of cancer cells. While the drug …
Potential application of ELAVL4 real-time quantitative reverse transcription-PCR for detection of disseminated neuroblastoma cells.
Swerts K, De Moerloose B, Dhooge C, Vandesompele J, Hoyoux C, Beiske K, Benoit Y, Laureys G, Philippé J. Swerts K, et al. Clin Chem. 2006 Mar;52(3):438-45. doi: 10.1373/clinchem.2005.059485. Epub 2005 Dec 29. Clin Chem. 2006. PMID: 16384890
In addition, 32%, 11%, and 38% of all BM, PB, and PBSC samples scored positive for TH, GALGT, or ELAVL4, respectively. The TH and ELAVL4 assays could detect 1 neuroblastoma cell in 10(6) mononuclear cells. ...Preliminary results indicated that persistence of high …
In addition, 32%, 11%, and 38% of all BM, PB, and PBSC samples scored positive for TH, GALGT, or ELAVL4, respectively. The TH and …
Reduced expression of ELAVL4 in male meningioma patients.
Stawski R, Piaskowski S, Stoczynska-Fidelus E, Wozniak K, Bienkowski M, Zakrzewska M, Witusik-Perkowska M, Jaskolski DJ, Och W, Papierz W, Sikorska B, Rieske P, Liberski PP. Stawski R, et al. Brain Tumor Pathol. 2013 Jul;30(3):160-6. doi: 10.1007/s10014-012-0117-x. Epub 2012 Sep 11. Brain Tumor Pathol. 2013. PMID: 22965691
Moreover, statistical correlation between the gene expression level and gender was significant for the ELAVL4 gene as we found it to be lower in males than in females. We conclude that meningiomas present different features depending on patient gender. We suggest that E …
Moreover, statistical correlation between the gene expression level and gender was significant for the ELAVL4 gene as we found it to …
83 results