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Year Number of Results
1996 1
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2003 7
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2006 4
2007 1
2008 1
2009 6
2010 4
2011 7
2012 5
2013 1
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86 results

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Page 1
FGF19-mediated ELF4 overexpression promotes colorectal cancer metastasis through transactivating FGFR4 and SRC.
Chen X, Chen J, Feng W, Huang W, Wang G, Sun M, Luo X, Wang Y, Nie Y, Fan D, Wu K, Xia L. Chen X, et al. Theranostics. 2023 Feb 22;13(4):1401-1418. doi: 10.7150/thno.82269. eCollection 2023. Theranostics. 2023. PMID: 36923538 Free PMC article.
ELF4 expression was also an independent predictor of poor prognosis. ...Fibroblast growth factor 19 (FGF19) upregulated ELF4 expression through the ERK1/2/SP1 axis. Clinically, ELF4 expression had a positive correlation with FGF19, FGFR4 and SRC, and CRC pati …
ELF4 expression was also an independent predictor of poor prognosis. ...Fibroblast growth factor 19 (FGF19) upregulated ELF4 e …
Suppression of ELF4 in ulcerative colitis predisposes host to colorectal cancer.
Du H, Xia H, Liu T, Li Y, Liu J, Xie B, Chen J, Liu T, Cao L, Liu S, Li S, Wang P, Wang D, Zhang Z, Li Y, Guo X, Wu A, Li M, You F. Du H, et al. iScience. 2021 Feb 9;24(3):102169. doi: 10.1016/j.isci.2021.102169. eCollection 2021 Mar 19. iScience. 2021. PMID: 33665583 Free PMC article.
Consistently, ELF4 deficiency leads to more severe DNA damage both in vitro and in vivo. Oral administration of montmorillonite powder can prevent the reduction of ELF4 in DSS-induced colitis models and lower the risk of colon tumor development during azoxymethane ( …
Consistently, ELF4 deficiency leads to more severe DNA damage both in vitro and in vivo. Oral administration of montmorillonite powde …
ELF4 is a critical component of a miRNA-transcription factor network and is a bridge regulator of glioblastoma receptor signaling and lipid dynamics.
Kosti A, Chiou J, Guardia GDA, Lei X, Balinda H, Landry T, Lu X, Qiao M, Gilbert A, Brenner A, Galante PAF, Tiziani S, Penalva LOF. Kosti A, et al. Neuro Oncol. 2023 Mar 14;25(3):459-470. doi: 10.1093/neuonc/noac179. Neuro Oncol. 2023. PMID: 35862252 Free PMC article.
We conducted a high-throughput functional siRNA screen in glioblastoma cells and identify E74 like ETS transcription factor 4 (ELF4) as the leading contributor to oncogenic phenotypes. METHODS: In vitro and in vivo assays were used to assess ELF4 impact on cancer …
We conducted a high-throughput functional siRNA screen in glioblastoma cells and identify E74 like ETS transcription factor 4 (ELF4) …
Roles and regulations of the ETS transcription factor ELF4/MEF.
Suico MA, Shuto T, Kai H. Suico MA, et al. J Mol Cell Biol. 2017 Jun 1;9(3):168-177. doi: 10.1093/jmcb/mjw051. J Mol Cell Biol. 2017. PMID: 27932483 Free PMC article. Review.
A member of the E74-like factor (ELF) subfamily of the ETS transcription factor family-myeloid elf-1-like factor (MEF), designated as ELF4-has been shown to be critically involved in immune response and signalling, osteogenesis, adipogenesis, cancer, and stem cell q …
A member of the E74-like factor (ELF) subfamily of the ETS transcription factor family-myeloid elf-1-like factor (MEF), designated as ELF …
ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9.
Xu A, Sun M, Li Z, Chu Y, Fang K, Zhang Y, Lian J, Zhang L, Chen T, Xu M. Xu A, et al. Acta Biochim Biophys Sin (Shanghai). 2024 Jan 25;56(1):129-139. doi: 10.3724/abbs.2023225. Acta Biochim Biophys Sin (Shanghai). 2024. PMID: 37674363 Free PMC article.
Furthermore, we demonstrate that ELF4 could promote cancer cell proliferation, migration, invasion, and stemness by in vivo assays. Through RNA-seq and ChIP assays, we find that the stemness-related gene fucosyltransferase 9 ( FUT9) is transcriptionally activated by …
Furthermore, we demonstrate that ELF4 could promote cancer cell proliferation, migration, invasion, and stemness by in vivo as …
High ELF4 expression in human cancers is associated with worse disease outcomes and increased resistance to anticancer drugs.
Kafita D, Daka V, Nkhoma P, Zulu M, Zulu E, Tembo R, Ngwira Z, Mwaba F, Sinkala M, Munsaka S. Kafita D, et al. PLoS One. 2021 Apr 9;16(4):e0248984. doi: 10.1371/journal.pone.0248984. eCollection 2021. PLoS One. 2021. PMID: 33836003 Free PMC article.
To this end, we performed a bioinformatics analysis to facilitate a detailed understanding of how the expression variations of ELF4 in human cancers are related to disease outcomes and the cancer cell drug responses. Here, using ELF4 mRNA expression da …
To this end, we performed a bioinformatics analysis to facilitate a detailed understanding of how the expression variations of ELF4 i …
Tumor-derived exosomes orchestrate the microRNA-128-3p/ELF4/CDX2 axis to facilitate the growth and metastasis of gastric cancer via delivery of LINC01091.
Wang Q, Zhang C, Cao S, Zhao H, Jiang R, Li Y. Wang Q, et al. Cell Biol Toxicol. 2023 Apr;39(2):519-536. doi: 10.1007/s10565-022-09728-y. Epub 2022 Jun 8. Cell Biol Toxicol. 2023. PMID: 35674868
In addition, luciferase, RNA pull-down, and ChIP assays offered evidence supporting the mechanism that LINC01091 bound to miR-128-3p that inversely targeted ELF4, and ELF4 transcriptionally activated CDX2 by binding to its promoter in GC cells. Moreover, Exo-sh-LINC …
In addition, luciferase, RNA pull-down, and ChIP assays offered evidence supporting the mechanism that LINC01091 bound to miR-128-3p that in …
[ELF4 promotes proliferation and inhibits apoptosis of human insulinoma cells by activating Akt signaling].
Wei G, Wang L, Wan X, Tan Y. Wei G, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2021 Aug 31;41(9):1329-1333. doi: 10.12122/j.issn.1673-4254.2021.09.06. Nan Fang Yi Ke Da Xue Xue Bao. 2021. PMID: 34658346 Free PMC article. Chinese.
METHODS: A human insulinoma BON cell line with stable overexpression of ELF4 (BON-ELF4 cells) was constructed using a recombinant retrovirus vector and the expression of ELF4 protein was verified using Western blotting. ...RESULTS: BON-ELF4 cell line w …
METHODS: A human insulinoma BON cell line with stable overexpression of ELF4 (BON-ELF4 cells) was constructed using a recombin …
ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation.
Sashida G, Liu Y, Elf S, Miyata Y, Ohyashiki K, Izumi M, Menendez S, Nimer SD. Sashida G, et al. Mol Cell Biol. 2009 Jul;29(13):3687-99. doi: 10.1128/MCB.01551-08. Epub 2009 Apr 20. Mol Cell Biol. 2009. PMID: 19380490 Free PMC article.
Several ETS transcription factors, including ELF4/MEF, can function as oncogenes in murine cancer models and are overexpressed in human cancer. ...Thus, ELF4/MEF promotes tumorigenesis by inhibiting both the p53 and p16/Rb pathways....
Several ETS transcription factors, including ELF4/MEF, can function as oncogenes in murine cancer models and are overexpressed …
Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1.
Gao J, Ao YQ, Zhang LX, Deng J, Wang S, Wang HK, Jiang JH, Ding JY. Gao J, et al. J Exp Clin Cancer Res. 2022 Oct 8;41(1):295. doi: 10.1186/s13046-022-02505-z. J Exp Clin Cancer Res. 2022. PMID: 36209117 Free PMC article.
Additionally, exosomal circZNF451 was demonstrated to induce an anti-inflammatory phenotype in macrophages and exhaustion of cytotoxic CD8(+) T cells, and enhanced TRIM56-mediated degradation of FXR1 to activate the ELF4-IRF4 pathway in macrophages. By transgenic mice, kno …
Additionally, exosomal circZNF451 was demonstrated to induce an anti-inflammatory phenotype in macrophages and exhaustion of cytotoxic CD8(+ …
86 results