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91 results

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Page 1
Colorectal cancer-associated mutations impair EphB1 kinase function.
Kim Y, Ahmed S, Miller WT. Kim Y, et al. J Biol Chem. 2023 Sep;299(9):105115. doi: 10.1016/j.jbc.2023.105115. Epub 2023 Jul 30. J Biol Chem. 2023. PMID: 37527777 Free PMC article.
In the intestinal epithelium, Eph signaling controls the positioning of cell types along the crypt-villus axis. Eph activity can suppress the progression of colorectal cancer (CRC). The most frequently mutated Eph receptor in metastatic CRC is EphB1. However, the fu …
In the intestinal epithelium, Eph signaling controls the positioning of cell types along the crypt-villus axis. Eph activity can suppress th …
Retraction.
[No authors listed] [No authors listed] J Cell Biochem. 2021 Nov;122 Suppl 1:S103. doi: 10.1002/jcb.30083. Epub 2021 Jul 19. J Cell Biochem. 2021. PMID: 34288066
Retraction: "Analgesic effects of microRNA-129-5p against bone cancer pain through the EphB1/EphrinB2 signaling pathway in mice," by Shao-Nan Yu, Gui-Feng Liu, Long-Yun Li, Guo-Qing Zhao, Lin Liu, Xue-Feng Li, J Cell Biochem. 2019; 2876-2885: The above article, publ …
Retraction: "Analgesic effects of microRNA-129-5p against bone cancer pain through the EphB1/EphrinB2 signaling pathway in mic …
Cell-cell contact-driven EphB1 cis- and trans- signalings regulate cancer stem cells enrichment after chemotherapy.
Wang L, Peng Q, Xie Y, Yin N, Xu J, Chen A, Yi J, Shi W, Tang J, Xiang J. Wang L, et al. Cell Death Dis. 2022 Nov 19;13(11):980. doi: 10.1038/s41419-022-05385-5. Cell Death Dis. 2022. PMID: 36402751 Free PMC article.
Further, we showed that EphB1 and p-EphB1 showed dynamic expression in the process of cancer cell dormancy and reactivation, where the expression profiles of EphB1 and p-EphB1 showed negatively correlated. ...EphB1 cis- and trans- signali …
Further, we showed that EphB1 and p-EphB1 showed dynamic expression in the process of cancer cell dormancy and reactiva …
Ligand-independent EphB1 signaling mediates TGF-beta-activated CDH2 and promotes lung cancer cell invasion and migration.
Wang L, Peng Q, Sai B, Zheng L, Xu J, Yin N, Feng X, Xiang J. Wang L, et al. J Cancer. 2020 Apr 7;11(14):4123-4131. doi: 10.7150/jca.44576. eCollection 2020. J Cancer. 2020. PMID: 32368295 Free PMC article.
Higher EphB1 expression was correlated with poor patient survival in lung cancer. Overexpression of EphB1 promoted the migration and invasion of lung cancer cells. On the contrast, Ephrin-B2, a transmembrane ligand for EphB1 forward signaling, i …
Higher EphB1 expression was correlated with poor patient survival in lung cancer. Overexpression of EphB1 promoted the …
Analgesic effects of microRNA-129-5p against bone cancer pain through the EphB1/EphrinB2 signaling pathway in mice.
Yu SN, Liu GF, Li LY, Zhao GQ, Liu L, Li XF. Yu SN, et al. J Cell Biochem. 2019 Mar;120(3):2876-2885. doi: 10.1002/jcb.26605. Epub 2018 Nov 30. J Cell Biochem. 2019. PMID: 29236320 Retracted.
The study aims to investigate the analgesic effects of microRNA-129-5p (miR-129-5p) on bone cancer pain (BCP) by targeting Eph receptor B1 (EphB1) through the EphB1/EphrinB2 signaling pathway. ...EphB1 is a target gene of miR-129-5p. The mechanical wit …
The study aims to investigate the analgesic effects of microRNA-129-5p (miR-129-5p) on bone cancer pain (BCP) by targeting Eph recept …
Prognostic values of EphB1/B2 and p-EphB1/B2 expression in non-small cell lung cancer.
Li L, He Y, Liu D, Li L, Chen F, Ran J, Yang L, Zhang L. Li L, et al. Int J Clin Exp Pathol. 2017 Sep 1;10(9):10092-10101. eCollection 2017. Int J Clin Exp Pathol. 2017. PMID: 31966900 Free PMC article.
However, little has been known about its prognostic values in non-small cell lung cancer (NSCLC). Thus, we studied the expression levels of EphB1/2 and p-EphB1/2 in both NSCLC tissue and normal lung tissue, and analyzed their correlations with clinicopatholog …
However, little has been known about its prognostic values in non-small cell lung cancer (NSCLC). Thus, we studied the expression lev …
Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells.
Kundu S, Nunes L, Adler J, Mathot L, Stoimenov I, Sjöblom T. Kundu S, et al. Cell Commun Signal. 2023 Dec 15;21(1):354. doi: 10.1186/s12964-023-01378-9. Cell Commun Signal. 2023. PMID: 38102712 Free PMC article.
BACKGROUND: Ephrin (EPH) receptors have been implicated in tumorigenesis and metastasis, but the functional understanding of mutations observed in human cancers is limited. We previously demonstrated reduced cell compartmentalisation for somatic EPHB1 mutations foun …
BACKGROUND: Ephrin (EPH) receptors have been implicated in tumorigenesis and metastasis, but the functional understanding of mutations obser …
Paradoxes of the EphB1 receptor in malignant brain tumors.
Wei W, Wang H, Ji S. Wei W, et al. Cancer Cell Int. 2017 Feb 8;17:21. doi: 10.1186/s12935-017-0384-z. eCollection 2017. Cancer Cell Int. 2017. PMID: 28194092 Free PMC article. Review.
This review focuses on EphB1 that has both tumor-suppressing and -promoting roles in some brain tumors. Understanding the intracellular mechanisms of EphB1 in tumorigenesis and metastasis of brain tumors might provide a foundation for the development of EphB1 …
This review focuses on EphB1 that has both tumor-suppressing and -promoting roles in some brain tumors. Understanding the intracellul …
EphB1 Suppression in Acute Myelogenous Leukemia: Regulating the DNA Damage Control System.
Kampen KR, Scherpen FJ, Garcia-Manero G, Yang H, Kaspers GJ, Cloos J, Zwaan CM, van den Heuvel-Eibrink MM, Kornblau SM, De Bont ES. Kampen KR, et al. Mol Cancer Res. 2015 Jun;13(6):982-92. doi: 10.1158/1541-7786.MCR-14-0660-T. Epub 2015 May 5. Mol Cancer Res. 2015. PMID: 25944917 Free PMC article.
Loss of ephrin receptor (EphB1) expression may associate with aggressive cancer phenotypes; however, the mechanism of action remains unclear. ...IMPLICATIONS: The tumor-suppressor function of EphB1 is clinically relevant across many malignancies, suggesting t …
Loss of ephrin receptor (EphB1) expression may associate with aggressive cancer phenotypes; however, the mechanism of action r …
Involvement of EphB1 receptor/ephrinB1 ligand in bone cancer pain.
Dong Y, Mao-Ying QL, Chen JW, Yang CJ, Wang YQ, Tan ZM. Dong Y, et al. Neurosci Lett. 2011 Jun 8;496(3):163-7. doi: 10.1016/j.neulet.2011.04.008. Epub 2011 Apr 14. Neurosci Lett. 2011. PMID: 21514363
At 16 days post inoculation, the pain relieving effect and the mRNA levels of inflammatory cytokines were detected after intrathecal administration of EphB1-Fc (blocker of EphB1 receptor, 10mug). The results showed that the EphB1/ephrinB1 expression was signi …
At 16 days post inoculation, the pain relieving effect and the mRNA levels of inflammatory cytokines were detected after intrathecal adminis …
91 results