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Year Number of Results
1994 1
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1998 4
1999 2
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2002 7
2003 2
2004 10
2005 7
2006 20
2007 11
2008 7
2009 24
2010 15
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2013 22
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2015 25
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374 results

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Page 1
Targeting receptor tyrosine kinase EphB4 in cancer therapy.
Chen Y, Zhang H, Zhang Y. Chen Y, et al. Semin Cancer Biol. 2019 Jun;56:37-46. doi: 10.1016/j.semcancer.2017.10.002. Epub 2017 Oct 6. Semin Cancer Biol. 2019. PMID: 28993206 Review.
This review discusses the structure and function of the EphB4 receptor, analyzes its potential as a target for anticancer therapy, and summarizes the information about inhibitors of EphB4 kinase activity. Conclusively, EphB4 is a challenging but promising the …
This review discusses the structure and function of the EphB4 receptor, analyzes its potential as a target for anticancer therapy, an …
Biological Significance of EphB4 Expression in Cancer.
Ullah A, Razzaq A, Zhou C, Ullah N, Shehzadi S, Aziz T, Alfaifi MY, Elbehairi SEI, Iqbal H. Ullah A, et al. Curr Protein Pept Sci. 2024;25(3):244-255. doi: 10.2174/0113892037269589231017055642. Curr Protein Pept Sci. 2024. PMID: 37909437 Review.
This article addresses the structure and function of the EphB4 receptor, analyses its possibility as an anticancer therapeutic target, and summarises knowledge of EphB4 kinase inhibitors. To summarise, EphB4 is a difficult but potential treatment option for …
This article addresses the structure and function of the EphB4 receptor, analyses its possibility as an anticancer therapeutic target …
Transcriptional and Post-Translational Control Mechanisms for EphB4 Expression in Physiology and Cancer Disease.
Scalia P, Maurancy J, Giordano A, Williams SJ. Scalia P, et al. Crit Rev Eukaryot Gene Expr. 2021;31(2):83-88. doi: 10.1615/CritRevEukaryotGeneExpr.2021037928. Crit Rev Eukaryot Gene Expr. 2021. PMID: 34347982 Review.
EphB4 is a membrane tyrosine kinase receptor involved in a number of physiologic and pathologic conditions, cancer being the one drawing the highest attention. In mammalians, EphB4 regulates blood vessel growth and differentiation. EphB4 also mediates …
EphB4 is a membrane tyrosine kinase receptor involved in a number of physiologic and pathologic conditions, cancer being the o …
EphrinB2-EphB4 Signaling in Neurooncological Disease.
Piffko A, Uhl C, Vajkoczy P, Czabanka M, Broggini T. Piffko A, et al. Int J Mol Sci. 2022 Jan 31;23(3):1679. doi: 10.3390/ijms23031679. Int J Mol Sci. 2022. PMID: 35163601 Free PMC article. Review.
However, the molecular signaling pathways are manifold and signaling of the EphB4 receptor or the ephrinB2 ligand is cancer type specific. Here we explore the impact of these signaling pathways in neurooncological disease, including glioma, brain metastasis, and spi …
However, the molecular signaling pathways are manifold and signaling of the EphB4 receptor or the ephrinB2 ligand is cancer ty …
Paradoxes of the EphB4 receptor in cancer.
Noren NK, Pasquale EB. Noren NK, et al. Cancer Res. 2007 May 1;67(9):3994-7. doi: 10.1158/0008-5472.CAN-07-0525. Cancer Res. 2007. PMID: 17483308 Review.
Recent findings have started to uncover the intriguing roles of the Eph family of receptor tyrosine kinases in normal epithelial cells and during oncogenic transformation. This review focuses on EphB4, an Eph receptor that has both tumor-suppressing and tumor-promoting act …
Recent findings have started to uncover the intriguing roles of the Eph family of receptor tyrosine kinases in normal epithelial cells and d …
PET imaging of colorectal and breast cancer by targeting EphB4 receptor with 64Cu-labeled hAb47 and hAb131 antibodies.
Liu S, Li D, Park R, Liu R, Xia Z, Guo J, Krasnoperov V, Gill PS, Li Z, Shan H, Conti PS. Liu S, et al. J Nucl Med. 2013 Jul;54(7):1094-100. doi: 10.2967/jnumed.112.116822. Epub 2013 May 10. J Nucl Med. 2013. PMID: 23667241 Free article. Review.
Accumulating evidence suggests that ephrin type B receptor 4 (EphB4) plays a key role in the progression of numerous cancer types. ...CONCLUSION: We have demonstrated that EphB4 can serve as a valid target for colorectal and breast cancer imaging. ...
Accumulating evidence suggests that ephrin type B receptor 4 (EphB4) plays a key role in the progression of numerous cancer ty …
M6PR- and EphB4-Rich Exosomes Secreted by Serglycin-Overexpressing Esophageal Cancer Cells Promote Cancer Progression.
Yan D, Cui D, Zhu Y, Chan CKW, Choi CHJ, Liu T, Lee NPY, Law S, Tsao SW, Ma S, Cheung ALM. Yan D, et al. Int J Biol Sci. 2023 Jan 1;19(2):625-640. doi: 10.7150/ijbs.79875. eCollection 2023. Int J Biol Sci. 2023. PMID: 36632458 Free PMC article.
Accumulating evidence shows that exosomes participate in cancer progression. However, the functions of cancer cell exosome-transmitted proteins are rarely studied. ...Cation-dependent mannose-6-phosphate receptor (M6PR) and ephrin type-B receptor 4 (EphB4) we …
Accumulating evidence shows that exosomes participate in cancer progression. However, the functions of cancer cell exosome-tra …
EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment.
Bhatia S, Nguyen D, Darragh LB, Van Court B, Sharma J, Knitz MW, Piper M, Bukkapatnam S, Gadwa J, Bickett TE, Bhuvane S, Corbo S, Wu B, Lee Y, Fujita M, Joshi M, Heasley LE, Ferris RL, Rodriguez O, Albanese C, Kapoor M, Pasquale EB, Karam SD. Bhatia S, et al. Nat Commun. 2022 Jun 20;13(1):3535. doi: 10.1038/s41467-022-31124-7. Nat Commun. 2022. PMID: 35725568 Free PMC article.
Differential outcomes of EphB4-ephrinB2 signaling offers formidable challenge for the development of cancer therapeutics. ...We observe that manipulating the EphB4 intracellular domain on cancer cells accelerates tumor growth and angiogenesis. ...
Differential outcomes of EphB4-ephrinB2 signaling offers formidable challenge for the development of cancer therapeutics. ...W …
May EPH/Ephrin Targeting Revolutionize Lung Cancer Treatment?
Psilopatis I, Karniadakis I, Danos KS, Vrettou K, Michaelidou K, Mavridis K, Agelaki S, Theocharis S. Psilopatis I, et al. Int J Mol Sci. 2022 Dec 21;24(1):93. doi: 10.3390/ijms24010093. Int J Mol Sci. 2022. PMID: 36613532 Free PMC article. Review.
Lung cancer (LC) is the leading cause of cancer death in the United States. ...However, the sole clinical trial incorporating a NSCLC patient could not describe objective anti-cancer effects after anti-EPHA2 antibody administration. Collectively, EPHs/ephrins …
Lung cancer (LC) is the leading cause of cancer death in the United States. ...However, the sole clinical trial incorporating …
Targeting the EphB4 receptor tyrosine kinase sensitizes HER2-positive breast cancer cells to Lapatinib.
Ding J, Yao Y, Huang G, Wang X, Yi J, Zhang N, Liu C, Wang K, Zhang Y, Wang M, Liu P, Ye M, Li M, Cheng H. Ding J, et al. Cancer Lett. 2020 Apr 10;475:53-64. doi: 10.1016/j.canlet.2020.01.032. Epub 2020 Jan 29. Cancer Lett. 2020. PMID: 32006616 Free article.
Clinical data analysis reveals that the expression of the EphB4 receptor tyrosine kinase is significantly elevated in HER2-positive breast cancer and high levels of EphB4 strongly correlate with poor disease prognosis. However, the impact of EphB4 acti …
Clinical data analysis reveals that the expression of the EphB4 receptor tyrosine kinase is significantly elevated in HER2-positive b …
374 results