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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1995 1
1996 1
2001 2
2002 3
2003 3
2004 2
2005 3
2006 5
2007 10
2008 14
2009 15
2010 12
2011 18
2012 23
2013 23
2014 21
2015 32
2016 24
2017 24
2018 34
2019 41
2020 44
2021 49
2022 32
2023 29
2024 13

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424 results

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Page 1
Overexpression of soluble epoxide hydrolase reduces post-ischemic recovery of cardiac contractile function.
Edin ML, Gruzdev A, Alyce Bradbury J, Graves JP, Muse GW, Goulding DR, Lih FB, DeGraff LM, Zeldin DC. Edin ML, et al. Biochem Pharmacol. 2024 Apr 26:116237. doi: 10.1016/j.bcp.2024.116237. Online ahead of print. Biochem Pharmacol. 2024. PMID: 38679211
Herein, we developed a mouse model with cardiomyocyte-selective expression of human EPHX2 (Myh6-EPHX2) that has significantly increased total EPHX2 expression and activity. Myh6-EPHX2 hearts exhibit strong, cardiomyocyte-selective expression of EPHX …
Herein, we developed a mouse model with cardiomyocyte-selective expression of human EPHX2 (Myh6-EPHX2) that has significantly …
Novel immune cross-talk between inflammatory bowel disease and IgA nephropathy.
Yan Q, Zhao Z, Liu D, Li J, Pan S, Duan J, Liu Z. Yan Q, et al. Ren Fail. 2024 Dec;46(1):2337288. doi: 10.1080/0886022X.2024.2337288. Epub 2024 Apr 17. Ren Fail. 2024. PMID: 38628140 Free PMC article.
The three algorithms identified 10 diagnostic genes, MAPK3, NFKB1, FDX1, EPHX2, SYNPO, KDF1, METTL7A, RIDA, HSDL2, and RIPK2; FDX1 and NFKB1 were enhanced in the kidney of IBD mice. ...
The three algorithms identified 10 diagnostic genes, MAPK3, NFKB1, FDX1, EPHX2, SYNPO, KDF1, METTL7A, RIDA, HSDL2, and RIPK2; FDX1 an …
Characterization and validation of fatty acid metabolism-related genes predicting prognosis, immune infiltration, and drug sensitivity in endometrial cancer.
Li H, Zhou T, Zhang Q, Yao Y, Hua T, Zhang J, Wang H. Li H, et al. Biotechnol Appl Biochem. 2024 Apr 14. doi: 10.1002/bab.2586. Online ahead of print. Biotechnol Appl Biochem. 2024. PMID: 38616327
Experiments in vitro confirmed that knockdown of epoxide hydrolase 2 (EPHX2) and acyl-CoA oxidase like (ACOXL) had an inhibitory effect on EC cells, as did overexpression of hematopoietic prostaglandin D synthase (HPGDS). ...Experiments in vitro and in vivo confirmed that …
Experiments in vitro confirmed that knockdown of epoxide hydrolase 2 (EPHX2) and acyl-CoA oxidase like (ACOXL) had an inhibitory effe …
Association between CYP4A11 and EPHX2 genetic polymorphisms and chronic kidney disease progression in hypertensive patients.
Suárez-Santisteban MA, Santos-Díaz G, García-Bernalt V, Pérez-Pico AM, Mingorance E, Mayordomo R, Dorado P. Suárez-Santisteban MA, et al. Nefrologia (Engl Ed). 2024 Mar 5:S2013-2514(24)00037-3. doi: 10.1016/j.nefroe.2024.01.020. Online ahead of print. Nefrologia (Engl Ed). 2024. PMID: 38448299 Free article.
For HT patients, a general biochemistry analysis, estimated glomerular filtration rate and genotyping for different CYPs and EPHX2 variant alleles was performed. RESULTS: CYP4A11 rs3890011, rs9332982 and EPHX2 rs41507953 polymorphisms, according to the dominant mode …
For HT patients, a general biochemistry analysis, estimated glomerular filtration rate and genotyping for different CYPs and EPHX2 va …
Regulation of soluble epoxide hydrolase in renal-associated diseases: insights from potential mechanisms to clinical researches.
Gao P, Cao Y, Ma L. Gao P, et al. Front Endocrinol (Lausanne). 2024 Feb 15;15:1304547. doi: 10.3389/fendo.2024.1304547. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38425758 Free PMC article. Review.
Initially, we expound upon the correlation between sEH and Epoxyeicosatrienoic acids (EETs) and also addressing the impact of sEH on other epoxy fatty acids, delineate prevalent EPHX2 single nucleotide polymorphisms (SNPs) associated with renal diseases, and delve into sEH …
Initially, we expound upon the correlation between sEH and Epoxyeicosatrienoic acids (EETs) and also addressing the impact of sEH on other e …
ALDH2 is a novel biomarker and exerts an inhibitory effect on melanoma.
Lei H, Liao J, Wang X, Huang R, Ying C, Yang J. Lei H, et al. Sci Rep. 2024 Feb 20;14(1):4183. doi: 10.1038/s41598-024-54084-y. Sci Rep. 2024. PMID: 38378847 Free PMC article.
We determined 6 hub genes with high prediction values for melanoma, which could distinguish tumor samples from normal samples. ALDH2, ADH1B, ALDH3A2, DPT, EPHX2, and GATM were down-regulated in A375 and SK-MEL-2 cells, compared with the human normal melanin cell line (PIG1 …
We determined 6 hub genes with high prediction values for melanoma, which could distinguish tumor samples from normal samples. ALDH2, ADH1B, …
A prognostic metabolism-related gene signature associated with the tumor immune microenvironment in neuroblastoma.
Yu X, Xu C, Zou Y, Liu W, Xie Y, Wu C. Yu X, et al. Am J Cancer Res. 2024 Jan 15;14(1):253-273. doi: 10.62347/IDXM4018. eCollection 2024. Am J Cancer Res. 2024. PMID: 38323276 Free PMC article.
We identified an eight-gene signature comprising metabolism-related genes in NB: ELOVL6, OSBPL9, RPL27A, HSD17B3, ACHE, AKR1C1, PIK3R1, and EPHX2. This panel effectively predicted disease-free survival, and was validated using an internal dataset from GSE49710 and two exte …
We identified an eight-gene signature comprising metabolism-related genes in NB: ELOVL6, OSBPL9, RPL27A, HSD17B3, ACHE, AKR1C1, PIK3R1, and …
Evaluating the efficacy and mechanisms of Hua-Zhuo-Ning-Fu-Decoction on psoriasis using integrated bioinformatics analysis and metabolomics.
Man S, Ma W, Jiang H, Haider A, Shi S, Li X, Wu Z, Song Y. Man S, et al. J Ethnopharmacol. 2024 May 10;325:117856. doi: 10.1016/j.jep.2024.117856. Epub 2024 Feb 3. J Ethnopharmacol. 2024. PMID: 38316220
RESULTS: In mice induced with IMQ, HZD shown good anti-psoriasis effects in terms of PASI score and epidermal acanthosis. 95 HZD targets and 77 bioactive chemicals connected to psoriasis were found by bioinformatics research; of these, 7 key targets (EPHX2, PLA2G2A, TBXAS1 …
RESULTS: In mice induced with IMQ, HZD shown good anti-psoriasis effects in terms of PASI score and epidermal acanthosis. 95 HZD targets and …
Establishment and validation of a novel peroxisome-related gene prognostic risk model in kidney clear cell carcinoma.
Zhang J, Zhao Q, Huang H, Lin X. Zhang J, et al. BMC Urol. 2024 Jan 31;24(1):26. doi: 10.1186/s12894-024-01404-z. BMC Urol. 2024. PMID: 38297313 Free PMC article.
RESULTS: Fourteen significant prognostic PRGs were identified using multiple analyses, and 9 genes (ABCD1, ACAD11, ACAT1, AGXT, DAO, EPHX2, FNDC5, HAO1, and HNGCLL1) were obtained to establish a prognostic model via LASSO Cox regression analysis. ...
RESULTS: Fourteen significant prognostic PRGs were identified using multiple analyses, and 9 genes (ABCD1, ACAD11, ACAT1, AGXT, DAO, EPHX …
Antioxidant Genes Variants and Their Association with Sperm DNA Fragmentation.
Sharif FA, Ashour MJ, Abuwarda HN, Ismail S, Salem N, Suleiman R, Hassouna N. Sharif FA, et al. Biochem Genet. 2024 Jan 31. doi: 10.1007/s10528-023-10559-7. Online ahead of print. Biochem Genet. 2024. PMID: 38294591
Genotype frequencies of NOS3 G > T (GT), SOD2 A > G (AA and AG), EPHX2 T > C (CC and CT), and AHR G > A (GA and GG) were significantly different between cases and controls. Allele frequencies of SOD2 (G-allele), and EPHX2 (T-allele) also significantly va …
Genotype frequencies of NOS3 G > T (GT), SOD2 A > G (AA and AG), EPHX2 T > C (CC and CT), and AHR G > A (GA and GG) were …
424 results