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The infarct core is well represented by the acute diffusion lesion: sustained reversal is infrequent.
Campbell BC, Purushotham A, Christensen S, Desmond PM, Nagakane Y, Parsons MW, Lansberg MG, Mlynash M, Straka M, De Silva DA, Olivot JM, Bammer R, Albers GW, Donnan GA, Davis SM; EPITHET–DEFUSE Investigators. Campbell BC, et al. J Cereb Blood Flow Metab. 2012 Jan;32(1):50-6. doi: 10.1038/jcbfm.2011.102. Epub 2011 Jul 20. J Cereb Blood Flow Metab. 2012. PMID: 21772309 Free PMC article. Clinical Trial.
Worse stroke outcome in atrial fibrillation is explained by more severe hypoperfusion, infarct growth, and hemorrhagic transformation.
Tu HT, Campbell BC, Christensen S, Desmond PM, De Silva DA, Parsons MW, Churilov L, Lansberg MG, Mlynash M, Olivot JM, Straka M, Bammer R, Albers GW, Donnan GA, Davis SM; EPITHET-DEFUSE Investigators. Tu HT, et al. Int J Stroke. 2015 Jun;10(4):534-40. doi: 10.1111/ijs.12007. Epub 2013 Mar 12. Int J Stroke. 2015. PMID: 23489996 Free PMC article. Clinical Trial.
Greater effect of stroke thrombolysis in the presence of arterial obstruction.
De Silva DA, Churilov L, Olivot JM, Christensen S, Lansberg MG, Mlynash M, Campbell BC, Desmond P, Straka M, Bammer R, Albers GW, Davis SM, Donnan GA; EPITHET-DEFUSE Investigators. De Silva DA, et al. Ann Neurol. 2011 Oct;70(4):601-5. doi: 10.1002/ana.22444. Ann Neurol. 2011. PMID: 22028220 Free PMC article. Clinical Trial.
Fluid-attenuated inversion recovery hyperintensity in acute ischemic stroke may not predict hemorrhagic transformation.
Campbell BC, Costello C, Christensen S, Ebinger M, Parsons MW, Desmond PM, Barber PA, Butcher KS, Levi CR, De Silva DA, Lansberg MG, Mlynash M, Olivot JM, Straka M, Bammer R, Albers GW, Donnan GA, Davis SM; EPITHET-DEFUSE Investigators. Campbell BC, et al. Cerebrovasc Dis. 2011;32(4):401-5. doi: 10.1159/000331467. Epub 2011 Oct 8. Cerebrovasc Dis. 2011. PMID: 21986096 Free PMC article.