Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 1
1991 1
1992 2
1993 4
1994 9
1995 20
1996 27
1997 28
1998 28
1999 26
2000 28
2001 30
2002 40
2003 36
2004 102
2005 46
2006 58
2007 69
2008 76
2009 68
2010 74
2011 63
2012 99
2013 134
2014 151
2015 144
2016 149
2017 114
2018 128
2019 129
2020 121
2021 109
2022 99
2023 73
2024 32

Text availability

Article attribute

Article type

Publication date

Search Results

2,022 results

Results by year

Filters applied: . Clear all
Page 1
ERBB3 mutations in cancer: biological aspects, prevalence and therapeutics.
Kiavue N, Cabel L, Melaabi S, Bataillon G, Callens C, Lerebours F, Pierga JY, Bidard FC. Kiavue N, et al. Oncogene. 2020 Jan;39(3):487-502. doi: 10.1038/s41388-019-1001-5. Epub 2019 Sep 13. Oncogene. 2020. PMID: 31519989 Review.
HER3, a member of the EGFR family of receptor tyrosine kinases coded by the ERBB3 gene, plays an important role in cancer, despite its lack of intrinsic kinase activity. ...We then show that ERBB3 mutations are not uncommon in many cancer types. Finall …
HER3, a member of the EGFR family of receptor tyrosine kinases coded by the ERBB3 gene, plays an important role in cancer, des …
ErbB Receptors and Cancer.
Wang Z. Wang Z. Methods Mol Biol. 2017;1652:3-35. doi: 10.1007/978-1-4939-7219-7_1. Methods Mol Biol. 2017. PMID: 28791631 Review.
The ErbB receptor family, also known as the EGF receptor family or type I receptor family, includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2, ErbB3/Her3, and ErbB4/Her4. Among all RTKs, EGFR was the first RTK identified and the first one …
The ErbB receptor family, also known as the EGF receptor family or type I receptor family, includes the epidermal growth factor (EGF) recept …
New insights into ErbB3 function and therapeutic targeting in cancer.
Hafeez U, Parslow AC, Gan HK, Scott AM. Hafeez U, et al. Expert Rev Anticancer Ther. 2020 Dec;20(12):1057-1074. doi: 10.1080/14737140.2020.1829485. Epub 2020 Oct 26. Expert Rev Anticancer Ther. 2020. PMID: 32981377 Review.
INTRODUCTION: The importance of ErbB3 receptor tyrosine kinase in cancer progression, primary and acquired drug resistance, has become steadily evident since its discovery in 1989. ...We outline the role of ErbB3 as a critical pathway for resistance to other …
INTRODUCTION: The importance of ErbB3 receptor tyrosine kinase in cancer progression, primary and acquired drug resistance, ha …
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.
Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, Lindeman N, Gale CM, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, Cappuzzo F, Mok T, Lee C, Johnson BE, Cantley LC, Jänne PA. Engelman JA, et al. Science. 2007 May 18;316(5827):1039-43. doi: 10.1126/science.1141478. Epub 2007 Apr 26. Science. 2007. PMID: 17463250
MET amplification was detected in 4 of 18 (22%) lung cancer specimens that had developed resistance to gefitinib or erlotinib. ...Thus, we propose that MET amplification may promote drug resistance in other ERBB-driven cancers as well....
MET amplification was detected in 4 of 18 (22%) lung cancer specimens that had developed resistance to gefitinib or erlotinib. ...Thu …
The ErbB/HER family of protein-tyrosine kinases and cancer.
Roskoski R Jr. Roskoski R Jr. Pharmacol Res. 2014 Jan;79:34-74. doi: 10.1016/j.phrs.2013.11.002. Epub 2013 Nov 20. Pharmacol Res. 2014. PMID: 24269963 Review.
Gefitinib, erlotinib, and afatinib are orally effective protein-kinase targeted quinazoline derivatives that are used in the treatment of ERBB1-mutant lung cancer. Lapatinib is an orally effective quinazoline derivative used in the treatment of ErbB2-overexpressing breast …
Gefitinib, erlotinib, and afatinib are orally effective protein-kinase targeted quinazoline derivatives that are used in the treatment of ER …
Efficacy and Safety of Patritumab Deruxtecan (HER3-DXd) in EGFR Inhibitor-Resistant, EGFR-Mutated Non-Small Cell Lung Cancer.
Jänne PA, Baik C, Su WC, Johnson ML, Hayashi H, Nishio M, Kim DW, Koczywas M, Gold KA, Steuer CE, Murakami H, Yang JC, Kim SW, Vigliotti M, Shi R, Qi Z, Qiu Y, Zhao L, Sternberg D, Yu C, Yu HA. Jänne PA, et al. Cancer Discov. 2022 Jan;12(1):74-89. doi: 10.1158/2159-8290.CD-21-0715. Epub 2021 Sep 21. Cancer Discov. 2022. PMID: 34548309 Free PMC article. Clinical Trial.
Receptor tyrosine-protein kinase ERBB3 (HER3) is expressed in most EGFR-mutated lung cancers but is not a known mechanism of resistance to EGFR inhibitors. ...The most common grade 3 treatment-emergent adverse events were hematologic toxicities. HER3-DXd has clinica …
Receptor tyrosine-protein kinase ERBB3 (HER3) is expressed in most EGFR-mutated lung cancers but is not a known mechanism of r …
The role of ErbB3 binding protein 1 in cancer: Friend or foe?
Nguyen DQ, Hoang DH, Nguyen Vo TT, Huynh V, Ghoda L, Marcucci G, Nguyen LXT. Nguyen DQ, et al. J Cell Physiol. 2018 Dec;233(12):9110-9120. doi: 10.1002/jcp.26951. Epub 2018 Aug 4. J Cell Physiol. 2018. PMID: 30076717 Review.
ErbB3, a member of the epidermal growth factor receptor family, reportedly plays an essential role in the regulation of cancer progression and therapeutic resistance. Numerous studies have indicated that ErbB3 binding protein 1 (Ebp1), a binding partner for …
ErbB3, a member of the epidermal growth factor receptor family, reportedly plays an essential role in the regulation of cancer …
Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3.
Ross JS, Fakih M, Ali SM, Elvin JA, Schrock AB, Suh J, Vergilio JA, Ramkissoon S, Severson E, Daniel S, Fabrizio D, Frampton G, Sun J, Miller VA, Stephens PJ, Gay LM. Ross JS, et al. Cancer. 2018 Apr 1;124(7):1358-1373. doi: 10.1002/cncr.31125. Epub 2018 Jan 16. Cancer. 2018. PMID: 29338072 Free PMC article.
BACKGROUND: In contrast to lung cancer, few precision treatments are available for colorectal cancer (CRC). ...The success of anti-HER2 therapies in ongoing clinical trials is a promising development for patients with CRC. Cancer 2018;124:1358-73. 2018 Founda …
BACKGROUND: In contrast to lung cancer, few precision treatments are available for colorectal cancer (CRC). ...The success of …
Role of erbB3 receptors in cancer therapeutic resistance.
Lee Y, Ma J, Lyu H, Huang J, Kim A, Liu B. Lee Y, et al. Acta Biochim Biophys Sin (Shanghai). 2014 Mar;46(3):190-8. doi: 10.1093/abbs/gmt150. Epub 2014 Jan 20. Acta Biochim Biophys Sin (Shanghai). 2014. PMID: 24449784 Free article. Review.
ErbB3 receptors are unique members of the erbB receptor tyrosine kinases (RTKs), which are often aberrantly expressed and/or activated in human cancers. ...Basic research on the underlying mechanisms implicated the functions of erbB3 as a major cause of treat …
ErbB3 receptors are unique members of the erbB receptor tyrosine kinases (RTKs), which are often aberrantly expressed and/or activate …
HER3/ErbB3, an emerging cancer therapeutic target.
Zhang N, Chang Y, Rios A, An Z. Zhang N, et al. Acta Biochim Biophys Sin (Shanghai). 2016 Jan;48(1):39-48. doi: 10.1093/abbs/gmv103. Epub 2015 Oct 24. Acta Biochim Biophys Sin (Shanghai). 2016. PMID: 26496898 Free article. Review.
Aberrant activation of the HER receptors and downstream signaling molecules tips the balance on cellular events, leading to various types of cancers. Monoclonal antibodies (mAbs) and small molecule inhibitors targeting EGFR and HER2 tyrosine kinase activities exhibit clini …
Aberrant activation of the HER receptors and downstream signaling molecules tips the balance on cellular events, leading to various types of …
2,022 results