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Year Number of Results
1998 2
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2009 3
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163 results

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Page 1
Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity.
Liu L, Li S, Qu Y, Bai H, Pan X, Wang J, Wang Z, Duan J, Zhong J, Wan R, Fei K, Xu J, Yuan L, Wang C, Xue P, Zhang X, Ma Z, Wang J. Liu L, et al. Cell Rep Med. 2023 Oct 17;4(10):101206. doi: 10.1016/j.xcrm.2023.101206. Epub 2023 Sep 27. Cell Rep Med. 2023. PMID: 37769655 Free PMC article.
Ablation of ERO1A in tumor cells substantially incites anti-tumor T cell immunity and promotes the efficacy of aPD-1 in therapeutic models. ...In human lung cancer, high ERO1A expression is associated with a higher risk of recurrence following neoadjuvant immunother …
Ablation of ERO1A in tumor cells substantially incites anti-tumor T cell immunity and promotes the efficacy of aPD-1 in therapeutic m …
Inhibition of ERO1a and IDO1 improves dendritic cell infiltration into pancreatic ductal adenocarcinoma.
Tay AHM, Cinotti R, Sze NSK, Lundqvist A. Tay AHM, et al. Front Immunol. 2023 Dec 22;14:1264012. doi: 10.3389/fimmu.2023.1264012. eCollection 2023. Front Immunol. 2023. PMID: 38187398 Free PMC article.
RESULTS: Inhibition of ERO1a and IDO1 significantly improved monocyte infiltration and differentiation into dendritic cells. LC-MS/MS analysis of the PDAC spheroid secretome identified downregulation of hypoxia and PDAC pathways, and upregulation of antigen presentation pa …
RESULTS: Inhibition of ERO1a and IDO1 significantly improved monocyte infiltration and differentiation into dendritic cells. LC-MS/MS …
SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA.
Germani S, Van Ho AT, Cherubini A, Varone E, Chernorudskiy A, Renna GM, Fumagalli S, Gobbi M, Lucchetti J, Bolis M, Guarrera L, Craparotta I, Rastelli G, Piccoli G, de Napoli C, Nogara L, Poggio E, Brini M, Cattaneo A, Bachi A, Simmen T, Calì T, Quijano-Roy S, Boncompagni S, Blaauw B, Ferreiro A, Zito E. Germani S, et al. Cell Rep Med. 2024 Mar 19;5(3):101439. doi: 10.1016/j.xcrm.2024.101439. Epub 2024 Feb 22. Cell Rep Med. 2024. PMID: 38402623 Free PMC article.
Here, we identify an interaction between SEPN1 and the ER-stress-induced oxidoreductase ERO1A. SEPN1 and ERO1A, both enriched in mitochondria-associated membranes (MAMs), are involved in the redox regulation of proteins. ERO1A depletion in SEPN1 knockout cell …
Here, we identify an interaction between SEPN1 and the ER-stress-induced oxidoreductase ERO1A. SEPN1 and ERO1A, both enriched …
The NFIB-ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells.
Zilli F, Marques Ramos P, Auf der Maur P, Jehanno C, Sethi A, Coissieux MM, Eichlisberger T, Sauteur L, Rouchon A, Bonapace L, Pinto Couto J, Rad R, Jensen MR, Banfi A, Stadler MB, Bentires-Alj M. Zilli F, et al. EMBO Mol Med. 2021 Apr 9;13(4):e13162. doi: 10.15252/emmm.202013162. Epub 2021 Mar 10. EMBO Mol Med. 2021. PMID: 33751828 Free PMC article.
Mechanistically and functionally, NFIB directly increases expression of the oxidoreductase ERO1A, which enhances HIF1alpha-VEGFA-mediated angiogenesis and colonization, the last and fatal step of the metastatic cascade. NFIB is thus clinically relevant: it is preferentiall …
Mechanistically and functionally, NFIB directly increases expression of the oxidoreductase ERO1A, which enhances HIF1alpha-VEGFA-medi …
ERO1A levels are a prognostic indicator in EGFR mutated non small cell lung cancer.
Voronkova MA, Johnson B, Gandhi N, Koomen JM, Patrick M, Shanthi Bhupathi S, Wu VM, Elliott A, Vanderwalde A, Halmos B, Hazlehurst LA. Voronkova MA, et al. NPJ Precis Oncol. 2024 Nov 4;8(1):250. doi: 10.1038/s41698-024-00736-1. NPJ Precis Oncol. 2024. PMID: 39496753 Free PMC article.
In addition, comparison of high versus low ERO1A expression among cohorts of EGFR(MUT)-NSCLC primary samples revealed that ERO1A expression correlated with increased expression of proteins that regulate secretion. ...Our work supports the role of ERO1A in mod …
In addition, comparison of high versus low ERO1A expression among cohorts of EGFR(MUT)-NSCLC primary samples revealed that ERO1A …
ERO1A inhibition mitigates neuronal ER stress and ameliorates UBQLN2(ALS) phenotypes in Drosophila melanogaster.
Yeewa R, Sangphukieo A, Jantaree P, Wongkummool W, Yamsri T, Poompouang S, Chaiyawat P, Lo Piccolo L, Jantrapirom S. Yeewa R, et al. Prog Neurobiol. 2024 Nov;242:102674. doi: 10.1016/j.pneurobio.2024.102674. Epub 2024 Oct 10. Prog Neurobiol. 2024. PMID: 39395630
In this study, we conducted an unbiased screening to systematically search for commonly up-regulated proteins in ER stress-related neurodegenerative conditions, with endoplasmic reticulum oxidoreductase 1 alpha (ERO1A) emerging as a significant hit. Further experiments con …
In this study, we conducted an unbiased screening to systematically search for commonly up-regulated proteins in ER stress-related neurodege …
Suppression of Microglial ERO1a Alleviates Inflammation and Enhances the Efficacy of Rehabilitative Training After Ischemic Stroke.
Ren J, Lv Y, Tian Q, Sun L, Miao P, Yang X, Xu LX, Feng CX, Li M, Gu Q, Feng X, Ding X. Ren J, et al. Mol Neurobiol. 2023 Aug;60(8):4429-4441. doi: 10.1007/s12035-023-03333-8. Epub 2023 Apr 27. Mol Neurobiol. 2023. PMID: 37100971
We next focused on one validated target named endoplasmic reticulum oxidoreductase 1 alpha (ERO1a) to study its role in stroke pathophysiology. We showed that over-expression of microglial ERO1a exacerbated inflammation, cell apoptosis and behavioral outcomes post m …
We next focused on one validated target named endoplasmic reticulum oxidoreductase 1 alpha (ERO1a) to study its role in stroke pathop …
Cordycepin reprogramming lipid metabolism to block metastasis and EMT via ERO1A/mTOR/SREBP1 axis in cholangiocarcinoma.
Zhou X, Li Y, Yang C, Chen D, Wang T, Liu T, Yan W, Su Z, Peng B, Ren X. Zhou X, et al. Life Sci. 2023 Aug 15;327:121698. doi: 10.1016/j.lfs.2023.121698. Epub 2023 Apr 18. Life Sci. 2023. PMID: 37080351
Cordycepin inhibits SREBP1 mediated fatty acid synthesis through the AKT/mTOR signaling pathway. Meanwhile, cordycepin can reduce ERO1A expression in HuCCT1 and QBC939 cells. ERO1A plays a role in malignant tumors. ERO1A promotes migration and lipid metabolis …
Cordycepin inhibits SREBP1 mediated fatty acid synthesis through the AKT/mTOR signaling pathway. Meanwhile, cordycepin can reduce ERO1A …
A Critical Role for ERO1α in Arterial Thrombosis and Ischemic Stroke.
Jha V, Xiong B, Kumari T, Brown G, Wang J, Kim K, Lee J, Asquith N, Gallagher J, Asherman L, Lambert T, Bai Y, Du X, Min JK, Sah R, Javaheri A, Razani B, Lee JM, Italiano JE, Cho J. Jha V, et al. Circ Res. 2023 May 26;132(11):e206-e222. doi: 10.1161/CIRCRESAHA.122.322473. Epub 2023 May 3. Circ Res. 2023. PMID: 37132383 Free PMC article.
Knockdown of PPARdelta Induces VEGFA-Mediated Angiogenesis via Interaction With ERO1A in Human Colorectal Cancer.
Luo W, He D, Zhang J, Ma Z, Chen K, Lv Z, Fan C, Yang L, Li Y, Zhou Z. Luo W, et al. Front Oncol. 2021 Oct 12;11:713892. doi: 10.3389/fonc.2021.713892. eCollection 2021. Front Oncol. 2021. PMID: 34712608 Free PMC article.
By tandem mass tag (TMT)-labeling proteomics and chromatin immunoprecipitation sequencing (ChIP-seq) analyses, endoplasmic reticulum oxidoreductase 1 alpha (ERO1A) was screened and predicted as a target gene of PPARdelta. This was verified by exploring the effect of coregu …
By tandem mass tag (TMT)-labeling proteomics and chromatin immunoprecipitation sequencing (ChIP-seq) analyses, endoplasmic reticulum oxidore …
163 results