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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 1
1995 2
2000 1
2001 1
2002 3
2003 1
2004 1
2005 4
2006 2
2007 6
2008 2
2009 6
2010 10
2011 10
2012 5
2013 4
2014 8
2015 14
2016 8
2017 12
2018 10
2019 7
2020 8
2021 14
2022 14
2023 8
2024 2

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147 results

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Page 1
Feedback activation of EGFR/wild-type RAS signaling axis limits KRAS(G12D) inhibitor efficacy in KRAS(G12D)-mutated colorectal cancer.
Feng J, Hu Z, Xia X, Liu X, Lian Z, Wang H, Wang L, Wang C, Zhang X, Pang X. Feng J, et al. Oncogene. 2023 May;42(20):1620-1633. doi: 10.1038/s41388-023-02676-9. Epub 2023 Apr 5. Oncogene. 2023. PMID: 37020035 Free PMC article.
Colorectal cancer (CRC), which shows a high degree of heterogeneity, is the third most deadly cancer worldwide. ...Mechanistically, MRTX1133 treatment downregulated the expression of ERBB receptor feedback inhibitor 1 (ERRFI1), a crucial negative regulator of …
Colorectal cancer (CRC), which shows a high degree of heterogeneity, is the third most deadly cancer worldwide. ...Mechanistic …
Capilliposide C from Lysimachia capillipes Restores Radiosensitivity in Ionizing Radiation-Resistant Lung Cancer Cells Through Regulation of ERRFI1/EGFR/STAT3 Signaling Pathway.
Wu K, Chen X, Feng J, Zhang S, Xu Y, Zhang J, Wu Q, You M, Xia B, Ma S. Wu K, et al. Front Oncol. 2021 Apr 1;11:644117. doi: 10.3389/fonc.2021.644117. eCollection 2021. Front Oncol. 2021. PMID: 33869036 Free PMC article.
Tumor xenograft experiments were conducted to observe the effect of LC-C and ERRFI1 on radiosensitivity of IR-resistant lung cancer cells in vivo. ...Forced expression of ERRFI1 alone could significantly increase the radiosensitivity of IR-resistant lung c …
Tumor xenograft experiments were conducted to observe the effect of LC-C and ERRFI1 on radiosensitivity of IR-resistant lung cance …
Differential Glucocorticoid-Dependent Regulation and Function of the ERRFI1 Gene in Triple-Negative Breast Cancer.
Mojica CAR, Ybañez WS, Olarte KCV, Poblete ABC, Bagamasbad PD. Mojica CAR, et al. Endocrinology. 2020 Jul 1;161(7):bqaa082. doi: 10.1210/endocr/bqaa082. Endocrinology. 2020. PMID: 32432675 Free PMC article.
In this study, we sought to decipher the molecular mechanisms that govern the GC-dependent induction of the tumor suppressor ERRFI1 gene, an inhibitor of epidermal growth factor receptor (EGFR) signaling, and characterize the role of the GC-ERRFI1 regulatory axis in …
In this study, we sought to decipher the molecular mechanisms that govern the GC-dependent induction of the tumor suppressor ERRFI1 g …
Inhibition of KHSRP sensitizes colorectal cancer to 5-fluoruracil through miR-501-5p-mediated ERRFI1 mRNA degradation.
Pan R, Cai W, Sun J, Yu C, Li P, Zheng M. Pan R, et al. J Cell Physiol. 2020 Feb;235(2):1576-1587. doi: 10.1002/jcp.29076. Epub 2019 Jul 16. J Cell Physiol. 2020. PMID: 31313286
Sensitivity to 5-FU mediated by KHSRP knockdown was reversed by ERRFI1 knockdown. We found that KHSRP decreased ERRFI1 mRNA expression indirectly. ...Mechanistically, the results of a luciferase assay suggested that miR-501-5p directly binds to the ERRFI1 3'- …
Sensitivity to 5-FU mediated by KHSRP knockdown was reversed by ERRFI1 knockdown. We found that KHSRP decreased ERRFI1 mRNA ex …
ERRFI1 induces apoptosis of hepatocellular carcinoma cells in response to tryptophan deficiency.
Cui M, Liu D, Xiong W, Wang Y, Mi J. Cui M, et al. Cell Death Discov. 2021 Oct 4;7(1):274. doi: 10.1038/s41420-021-00666-y. Cell Death Discov. 2021. PMID: 34608122 Free PMC article.
Moreover, ERRFI1 induces apoptosis by binding PDCD2 in HCC cells, PDCD2 knockdown decreases the ERRFI1-induced apoptosis in HCC cells. Thus, we conclude that ERRFI1-induced apoptosis increases the sensitivity of HCC cells to tryptophan deficiency and ERRFI …
Moreover, ERRFI1 induces apoptosis by binding PDCD2 in HCC cells, PDCD2 knockdown decreases the ERRFI1-induced apoptosis in HC …
Differential roles of ERRFI1 in EGFR and AKT pathway regulation affect cancer proliferation.
Cairns J, Fridley BL, Jenkins GD, Zhuang Y, Yu J, Wang L. Cairns J, et al. EMBO Rep. 2018 Mar;19(3):e44767. doi: 10.15252/embr.201744767. Epub 2018 Jan 15. EMBO Rep. 2018. PMID: 29335246 Free PMC article.
AKT signaling is modulated by a complex network of regulatory proteins and is commonly deregulated in cancer. Here, we present a dual mechanism of AKT regulation by the ERBB receptor feedback inhibitor 1 (ERRFI1). ...Finally, our data also suggest targeting of EFFRI …
AKT signaling is modulated by a complex network of regulatory proteins and is commonly deregulated in cancer. Here, we present a dual …
Gene 33/Mig6/ERRFI1, an Adapter Protein with Complex Functions in Cell Biology and Human Diseases.
Xu D, Li C. Xu D, et al. Cells. 2021 Jun 22;10(7):1574. doi: 10.3390/cells10071574. Cells. 2021. PMID: 34206547 Free PMC article. Review.
Gene 33 (also named Mig6, RALT, and ERRFI1) is an adapter/scaffold protein with a calculated molecular weight of about 50 kD. ...
Gene 33 (also named Mig6, RALT, and ERRFI1) is an adapter/scaffold protein with a calculated molecular weight of about 50 kD. ...
Precision oncology strategy in cetuximab-resistant ERRFI1-mutant colon cancer: case report of disease progression on afatinib.
Kuznetsova O, Lebedeva A, Kavun A, Belova E, Fedyanin M, Mileyko V, Ivanov M, Nosov D. Kuznetsova O, et al. Am J Transl Res. 2023 Sep 15;15(9):5785-5790. eCollection 2023. Am J Transl Res. 2023. PMID: 37854204 Free PMC article.
Despite the existence of effective first and second line therapy options for patients with colorectal cancer, heavily treated patients have limited additional therapies. ...The patient received a combination of afatinib and bevacizumab due to the presence of ERRFI1 …
Despite the existence of effective first and second line therapy options for patients with colorectal cancer, heavily treated patient …
A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements.
Fish L, Khoroshkin M, Navickas A, Garcia K, Culbertson B, Hänisch B, Zhang S, Nguyen HCB, Soto LM, Dermit M, Mardakheh FK, Molina H, Alarcón C, Najafabadi HS, Goodarzi H. Fish L, et al. Science. 2021 May 14;372(6543):eabc7531. doi: 10.1126/science.abc7531. Science. 2021. PMID: 33986153 Free PMC article.
Aberrant alternative splicing is a hallmark of cancer, yet the underlying regulatory programs that control this process remain largely unknown. ...Our findings establish a noncanonical regulatory role for SNRPA1 as a prometastatic splicing enhancer in breast cancer. …
Aberrant alternative splicing is a hallmark of cancer, yet the underlying regulatory programs that control this process remain largel …
Mig-6 Mouse Model of Endometrial Cancer.
Kim TH, Yoo JY, Jeong JW. Kim TH, et al. Adv Exp Med Biol. 2017;943:243-259. doi: 10.1007/978-3-319-43139-0_8. Adv Exp Med Biol. 2017. PMID: 27910070
Endometrial cancer is a frequently occurring gynecological disorder. Estrogen-dependent endometrioid carcinoma is the most common type of gynecological cancer. ...P4 antagonizes the growth-promoting properties of E2 in the uterus. P4 prevents the development of endo …
Endometrial cancer is a frequently occurring gynecological disorder. Estrogen-dependent endometrioid carcinoma is the most common typ …
147 results