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Page 1
Review: Ewing Sarcoma Predisposition.
Gargallo P, Yáñez Y, Juan A, Segura V, Balaguer J, Torres B, Oltra S, Castel V, Cañete A. Gargallo P, et al. Pathol Oncol Res. 2020 Oct;26(4):2057-2066. doi: 10.1007/s12253-019-00765-3. Epub 2019 Oct 26. Pathol Oncol Res. 2020. PMID: 31656020 Free article. Review.
Little is known about Ewing sarcoma predisposition, although the role of environmental factors, ethnicity and certain polymorphisms on Ewing sarcoma susceptibility has been studied during the last few years. Its prevalence among cancer predisposition syndromes has also bee …
Little is known about Ewing sarcoma predisposition, although the role of environmental factors, ethnicity and certain polymorphisms on Ewing …
Systematic identification of genomic markers of drug sensitivity in cancer cells.
Garnett MJ, Edelman EJ, Heidorn SJ, Greenman CD, Dastur A, Lau KW, Greninger P, Thompson IR, Luo X, Soares J, Liu Q, Iorio F, Surdez D, Chen L, Milano RJ, Bignell GR, Tam AT, Davies H, Stevenson JA, Barthorpe S, Lutz SR, Kogera F, Lawrence K, McLaren-Douglas A, Mitropoulos X, Mironenko T, Thi H, Richardson L, Zhou W, Jewitt F, Zhang T, O'Brien P, Boisvert JL, Price S, Hur W, Yang W, Deng X, Butler A, Choi HG, Chang JW, Baselga J, Stamenkovic I, Engelman JA, Sharma SV, Delattre O, Saez-Rodriguez J, Gray NS, Settleman J, Futreal PA, Haber DA, Stratton MR, Ramaswamy S, McDermott U, Benes CH. Garnett MJ, et al. Nature. 2012 Mar 28;483(7391):570-5. doi: 10.1038/nature11005. Nature. 2012. PMID: 22460902 Free PMC article.
Here, to uncover new biomarkers of sensitivity and resistance to cancer therapeutics, we screened a panel of several hundred cancer cell lines--which represent much of the tissue-type and genetic diversity of human cancers--with 130 drugs under clinical and p …
Here, to uncover new biomarkers of sensitivity and resistance to cancer therapeutics, we screened a panel of several hundred cance …
EWSR1-FLI1 Activation of the Cancer/Testis Antigen FATE1 Promotes Ewing Sarcoma Survival.
Gallegos ZR, Taus P, Gibbs ZA, McGlynn K, Gomez NC, Davis I, Whitehurst AW. Gallegos ZR, et al. Mol Cell Biol. 2019 Jun 27;39(14):e00138-19. doi: 10.1128/MCB.00138-19. Print 2019 Jul 15. Mol Cell Biol. 2019. PMID: 31036566 Free PMC article.
Ewing sarcoma is characterized by a pathognomonic chromosomal translocation that generates the EWSR1-FLI1 chimeric transcription factor. The transcriptional targets of EWSR1-FLI1 that are essential for tumorigenicity are incompletely defined. Here, we found that …
Ewing sarcoma is characterized by a pathognomonic chromosomal translocation that generates the EWSR1-FLI1 chimeric transcription fact …
Epithelioid and spindle cell rhabdomyosarcoma with EWSR1::TFCP2 fusion mimicking metastatic lung cancer: A case report and literature review.
Haug L, Doll J, Appenzeller S, Kunzmann V, Rosenwald A, Maurus K, Gerhard-Hartmann E. Haug L, et al. Pathol Res Pract. 2023 Sep;249:154779. doi: 10.1016/j.prp.2023.154779. Epub 2023 Aug 22. Pathol Res Pract. 2023. PMID: 37633005 Review.
Rhabdomyosarcoma (RMS) with EWSR1/FUS::TFCP2 fusion is an emerging, molecularly defined, rare subtype of RMS. ...We report here a case of a 55-year-old woman with an RMS with EWSR1::TFCP2 fusion mimicking metastatic lung cancer in view of the clinical and mic …
Rhabdomyosarcoma (RMS) with EWSR1/FUS::TFCP2 fusion is an emerging, molecularly defined, rare subtype of RMS. ...We report here a cas …
Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation.
Orth MF, Surdez D, Faehling T, Ehlers AC, Marchetto A, Grossetête S, Volckmann R, Zwijnenburg DA, Gerke JS, Zaidi S, Alonso J, Sastre A, Baulande S, Sill M, Cidre-Aranaz F, Ohmura S, Kirchner T, Hauck SM, Reischl E, Gymrek M, Pfister SM, Strauch K, Koster J, Delattre O, Grünewald TGP. Orth MF, et al. Cell Rep. 2022 Dec 6;41(10):111761. doi: 10.1016/j.celrep.2022.111761. Cell Rep. 2022. PMID: 36476851 Free PMC article.
Ewing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors converting polymorphic GGAA microsatellites (mSats) into potent neo-enhancers. ...Here we present the Ewing Sarcoma Cell Line Atlas (ESCLA), comprising whole-genome, DNA methylation, transcripto …
Ewing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors converting polymorphic GGAA microsatellites (mSats) in …
Ewing sarcoma and Ewing-like tumors.
Sbaraglia M, Righi A, Gambarotti M, Dei Tos AP. Sbaraglia M, et al. Virchows Arch. 2020 Jan;476(1):109-119. doi: 10.1007/s00428-019-02720-8. Epub 2019 Dec 4. Virchows Arch. 2020. PMID: 31802230 Review.
In fact, in addition to Ewing sarcoma, we currently recognize three main categories: round cell sarcomas with EWSR1 gene fusion with non-ETS family members, CIC-rearranged sarcomas, and BCOR-rearranged sarcomas. ...In consideration of the extreme rarity of many of these tu …
In fact, in addition to Ewing sarcoma, we currently recognize three main categories: round cell sarcomas with EWSR1 gene fusion with …
EWSR1-SMAD3-Positive Fibroblastic Tumor.
Foot O, Hallin M, Jones RL, Sumathi VP, Thway K. Foot O, et al. Int J Surg Pathol. 2021 Apr;29(2):179-181. doi: 10.1177/1066896920938124. Epub 2020 Jul 3. Int J Surg Pathol. 2021. PMID: 32615834
EWSR1-SMAD3-positive fibroblastic tumor is a recently characterized neoplasm with distinct clinicopathologic features and recurrent EWSR1-SMAD3 gene fusion. ...
EWSR1-SMAD3-positive fibroblastic tumor is a recently characterized neoplasm with distinct clinicopathologic features and recurrent …
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S. Toper MH, et al. Adv Anat Pathol. 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. Adv Anat Pathol. 2021. PMID: 33405400 Review.
Salivary gland neoplasms are an uncommon and widely heterogeneous group of tumors. ...Genomic aberrations, especially specific chromosomal rearrangements including CRTC1-MAML2 and CRTC3-MAML2 in mucoepidermoid carcinoma, MYB-NFIB and MYBL1-NFIB fusions in adenoid cystic ca …
Salivary gland neoplasms are an uncommon and widely heterogeneous group of tumors. ...Genomic aberrations, especially specific chromo …
Mesenchymal Tumors with EWSR1 Gene Rearrangements.
Thway K, Fisher C. Thway K, et al. Surg Pathol Clin. 2019 Mar;12(1):165-190. doi: 10.1016/j.path.2018.10.007. Surg Pathol Clin. 2019. PMID: 30709442 Review.
Among the various genes that can be rearranged in soft tissue neoplasms associated with nonrandom chromosomal translocations, EWSR1 is the most frequent one to partner with other genes to generate recurrent fusion genes. ...This review summarizes the growing list of …
Among the various genes that can be rearranged in soft tissue neoplasms associated with nonrandom chromosomal translocations, EWSR …
Ewing Sarcoma Drug Therapy: Current Standard of Care and Emerging Agents.
Setty BA, Gikandi A, DuBois SG. Setty BA, et al. Paediatr Drugs. 2023 Jul;25(4):389-397. doi: 10.1007/s40272-023-00568-9. Epub 2023 Apr 4. Paediatr Drugs. 2023. PMID: 37014523 Review.
Ewing sarcoma is a translocation-associated sarcoma mainly impacting adolescents and young adults. The classic translocation (EWSR1::FLI1) leads to a fusion oncoprotein that functions as an aberrant transcription factor. ...
Ewing sarcoma is a translocation-associated sarcoma mainly impacting adolescents and young adults. The classic translocation (EWSR1:: …
1,493 results