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Page 1
A comparison of sodium calcium edetate (edetate calcium disodium) and succimer (DMSA) in the treatment of inorganic lead poisoning.
Bradberry S, Vale A. Bradberry S, et al. Clin Toxicol (Phila). 2009 Nov;47(9):841-58. doi: 10.3109/15563650903321064. Clin Toxicol (Phila). 2009. PMID: 19852620 Review.
INTRODUCTION: This article reviews the experimental and clinical studies that have compared the efficacy (impact on urine lead excretion, blood and tissue lead concentrations, resolution of features and survival) of sodium calcium edetate (edetate calcium disodiu …
INTRODUCTION: This article reviews the experimental and clinical studies that have compared the efficacy (impact on urine lead excretion, bl …
Edetate calcium disodium nanoparticle dry powder inhalation: a novel approach against heavy metal decorporation.
Kumar N, Soni S, Jaimini A, Ahmad FJ, Bhatnagar A, Mittal G. Kumar N, et al. Int J Pharm. 2011 Sep 15;416(1):376-83. doi: 10.1016/j.ijpharm.2011.06.038. Epub 2011 Jun 28. Int J Pharm. 2011. PMID: 21740960 Clinical Trial.
Objective was to develop and characterize nano-edetate calcium disodium (Ca-Na(2)EDTA) dry powder inhaler (DPI), and assess its in vitro and in vivo deposition using pharmacoscintigraphy techniques. ...
Objective was to develop and characterize nano-edetate calcium disodium (Ca-Na(2)EDTA) dry powder inhaler (DPI), and as …
A comparative study of edetate calcium disodium and dimercaptosuccinic acid in the treatment of lead poisoning in adults.
Sakthithasan K, Lévy P, Poupon J, Garnier R. Sakthithasan K, et al. Clin Toxicol (Phila). 2018 Nov;56(11):1143-1149. doi: 10.1080/15563650.2018.1478424. Epub 2018 Jun 11. Clin Toxicol (Phila). 2018. PMID: 29889577 Free article.
BACKGROUND: We evaluated the efficacy of two antidotes, edetate calcium disodium (CaNa(2)EDTA) and dimercaptosuccinic acid (DMSA), for the treatment of lead poisoning in adults. ...
BACKGROUND: We evaluated the efficacy of two antidotes, edetate calcium disodium (CaNa(2)EDTA) and dimercaptosuccinic a …
Lead toxicity and chelation therapy.
Gracia RC, Snodgrass WR. Gracia RC, et al. Am J Health Syst Pharm. 2007 Jan 1;64(1):45-53. doi: 10.2146/ajhp060175. Am J Health Syst Pharm. 2007. PMID: 17189579 Review.

Chelation is generally not indicated for adults with blood lead concentrations of < 45 microg/dL because of the potential risk of adverse drug events and concerns about remobilized lead, and chelation for children with blood lead concentrations of < 45 microg/dL remains con

…

Chelation is generally not indicated for adults with blood lead concentrations of < 45 microg/dL because of the potential risk of adverse

…
Effect of edetate calcium disodium on yttrium-90 activity in bone of mice.
Watanabe N, Oriuchi N, Tanada S, Murata H, Inoue T, Kim EE, Sasaki Y, Endo K. Watanabe N, et al. Ann Nucl Med. 1999 Dec;13(6):397-400. doi: 10.1007/BF03164933. Ann Nucl Med. 1999. PMID: 10656273
The kinetics of Yttrium-90 (Y-90) in bone of mice was investigated in combination with edetate calcium disodium (CaNa2EDTA). One group of mice were intraperitoneally administered 37.5 mg/kg CaNa2EDTA or 0.9% NaCl as a control at 1, 22, 34, 46, 58, 70, 82, 94, …
The kinetics of Yttrium-90 (Y-90) in bone of mice was investigated in combination with edetate calcium disodium (CaNa2E …
Lightening the lead load in children.
Ellis MR, Kane KY. Ellis MR, et al. Am Fam Physician. 2000 Aug 1;62(3):545-54, 559-60. Am Fam Physician. 2000. PMID: 10950212 Free article. Review.
Children with lead levels of 45 to 69 microg per dL (2.15 to 3.35 pmol per L) should receive chelation therapy using succimer (DMSA) or edetate calcium disodium (CaNa2EDTA). Use of both CaNa2EDTA and dimercaprol (BAL in oil) is indicated in children with bloo …
Children with lead levels of 45 to 69 microg per dL (2.15 to 3.35 pmol per L) should receive chelation therapy using succimer (DMSA) or e …
Effects of sodium para-aminosalicylic acid on chelation treatment in Pb-exposed mice.
Li Y, Liang Y, Fang YY, Chen J, Zheng XW, Zhou WW, Lu LL, Aschner M, Ou SY, Jiang YM. Li Y, et al. Toxicol Ind Health. 2023 Aug;39(8):464-470. doi: 10.1177/07482337231183208. Epub 2023 Jul 5. Toxicol Ind Health. 2023. PMID: 37404003
Four hour later, mice were subcutaneously (back) injected (s.c.) with (80, 160, 240 mg/kg) PAS-Na or 240 mg/kg edetate calcium disodium (CaNa(2)EDTA) or an equivalent amount of saline, once per day for 6 days. ...
Four hour later, mice were subcutaneously (back) injected (s.c.) with (80, 160, 240 mg/kg) PAS-Na or 240 mg/kg edetate calcium …
Chelation therapy to treat lead toxicity in children.
Wegmann K. Wegmann K. Minn Med. 1992 Nov;75(11):25-7. Minn Med. 1992. PMID: 1331737 Review.
Experimental data have raised concerns about potential central nervous system effects of the most widely used chelating agent, edetate calcium disodium. A newly licensed chelating agent, succimer, appears to have fewer side effects, appears to be more effecti …
Experimental data have raised concerns about potential central nervous system effects of the most widely used chelating agent, edetate …
26 results