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The EEF1AKMT3/MAP2K7/TP53 axis suppresses tumor invasiveness and metastasis in gastric cancer.
Hong YH, Aziz N, Park JG, Lee D, Kim JK, Kim SA, Choi W, Lee CY, Lee HP, Huyen Trang HT, Kim HG, Jeon YJ, Kim B, Kim Y, Kim KH, Yoo BC, Han JW, Parameswaran N, Kim JH, Hur H, Cho JY. Hong YH, et al. Cancer Lett. 2022 Sep 28;544:215803. doi: 10.1016/j.canlet.2022.215803. Epub 2022 Jun 24. Cancer Lett. 2022. PMID: 35753528
In addition, EEF1AKMT3-knockdown induced gastric tumor invasiveness and migration. ...Furthermore, EEF1AKMT3, p-MAP2K7, and TP53 protein levels were positively correlated in GC tissues. ...
In addition, EEF1AKMT3-knockdown induced gastric tumor invasiveness and migration. ...Furthermore, EEF1AKMT3, p-MAP2K7, and TP …
Endothelial RIPK1 protects artery bypass graft against arteriosclerosis by regulating SMC growth.
Lu Y, Leng Y, Li Y, Wang J, Wang W, Wang R, Liu Y, Tan Q, Yang W, Jiang Y, Cai J, Yuan H, Weng L, Xu Q. Lu Y, et al. Sci Adv. 2023 Sep;9(35):eadh8939. doi: 10.1126/sciadv.adh8939. Epub 2023 Aug 30. Sci Adv. 2023. PMID: 37647392 Free PMC article.
Endothelial RIPK1 knockout exacerbated graft stenosis by increasing secretion of N-Shh. Mechanistically, RIPK1 directly phosphorylated EEF1AKMT3 at Ser(26), inhibiting its methyltransferase activity and global protein synthesis, which further attenuated N-Shh translation a …
Endothelial RIPK1 knockout exacerbated graft stenosis by increasing secretion of N-Shh. Mechanistically, RIPK1 directly phosphorylated EE …
SETD2 regulates the methylation of translation elongation factor eEF1A1 in clear cell renal cell carcinoma.
Hapke R, Venton L, Rose KL, Sheng Q, Reddy A, Prather R, Jones A, Rathmell WK, Haake SM. Hapke R, et al. Kidney Cancer J. 2022;6(3):179-193. doi: 10.3233/kca-220009. Epub 2022 Nov 18. Kidney Cancer J. 2022. PMID: 36684483 Free PMC article.
RESULTS: We observed decreased lysine methylation of the translation elongation factor eEF1A1. EEF1AKMT2 and EEF1AKMT3 are known to methylate eEF1A1, and we show here that their expression is dependent on SET-domain function of SETD2. ...
RESULTS: We observed decreased lysine methylation of the translation elongation factor eEF1A1. EEF1AKMT2 and EEF1AKMT3 are known to m …
Early response to heat stress in Chinese tongue sole (Cynoglossus semilaevis): performance of different sexes, candidate genes and networks.
Wang Q, Hao X, Liu K, Feng B, Li S, Zhang Z, Tang L, Mahboob S, Shao C. Wang Q, et al. BMC Genomics. 2020 Oct 27;21(1):745. doi: 10.1186/s12864-020-07157-x. BMC Genomics. 2020. PMID: 33109079 Free PMC article.
Furthermore, a total of 1048 DEGs were shared among females, pesudomales and males, which may represent the inherent difference between high and normal temperatures. Genes, such as eef1akmt3, eef1akmt4, pnmt and hsp family members, were found. CONCLUSIONS: Our results depi …
Furthermore, a total of 1048 DEGs were shared among females, pesudomales and males, which may represent the inherent difference between high …