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Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis.
Smeele KM, Southworth R, Wu R, Xie C, Nederlof R, Warley A, Nelson JK, van Horssen P, van den Wijngaard JP, Heikkinen S, Laakso M, Koeman A, Siebes M, Eerbeek O, Akar FG, Ardehali H, Hollmann MW, Zuurbier CJ. Smeele KM, et al. Among authors: eerbeek o. Circ Res. 2011 May 13;108(10):1165-9. doi: 10.1161/CIRCRESAHA.111.244962. Epub 2011 Apr 28. Circ Res. 2011. PMID: 21527739
Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia/reperfusion injury.
Wu R, Smeele KM, Wyatt E, Ichikawa Y, Eerbeek O, Sun L, Chawla K, Hollmann MW, Nagpal V, Heikkinen S, Laakso M, Jujo K, Wasserstrom JA, Zuurbier CJ, Ardehali H. Wu R, et al. Among authors: eerbeek o. Circ Res. 2011 Jan 7;108(1):60-9. doi: 10.1161/CIRCRESAHA.110.223115. Epub 2010 Nov 11. Circ Res. 2011. PMID: 21071708 Free PMC article.
Reduced hexokinase II impairs muscle function 2 wk after ischemia-reperfusion through increased cell necrosis and fibrosis.
Smeele KM, Eerbeek O, Schaart G, Koeman A, Bezemer R, Nelson JK, Ince C, Nederlof R, Boek M, Laakso M, de Haan A, Drost MR, Hollmann MW, Zuurbier CJ. Smeele KM, et al. Among authors: eerbeek o. J Appl Physiol (1985). 2012 Aug 15;113(4):608-18. doi: 10.1152/japplphysiol.01494.2011. Epub 2012 Jun 21. J Appl Physiol (1985). 2012. PMID: 22723631 Free article.
Reducing mitochondrial bound hexokinase II mediates transition from non-injurious into injurious ischemia/reperfusion of the intact heart.
Nederlof R, Gürel-Gurevin E, Eerbeek O, Xie C, Deijs GS, Konkel M, Hu J, Weber NC, Schumacher CA, Baartscheer A, Mik EG, Hollmann MW, Akar FG, Zuurbier CJ. Nederlof R, et al. Among authors: eerbeek o. J Physiol Biochem. 2016 Aug;73(3):323-333. doi: 10.1007/s13105-017-0555-3. Epub 2017 Mar 3. J Physiol Biochem. 2016. PMID: 28258543 Free PMC article.
38 results