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Page 1
EFCAB2 is a novel calcium-binding protein in mouse testis and sperm.
Shawki HH, Ishikawa-Yamauchi Y, Kawashima A, Katoh Y, Matsuda M, Al-Soudy AS, Minisy FM, Kuno A, Gulibaikelamu X, Hirokawa T, Takahashi S, Oishi H. Shawki HH, et al. PLoS One. 2019 Apr 1;14(4):e0214687. doi: 10.1371/journal.pone.0214687. eCollection 2019. PLoS One. 2019. PMID: 30933994 Free PMC article.
Results revealed extensive conservation of EFCAB2 among different eukaryotic orthologs. The constructed 3D model predicted that mouse EFCAB2 contains seven alpha-helices and two EF-hand motifs. ...Native and recombinant EFCAB2 protein were detected by western …
Results revealed extensive conservation of EFCAB2 among different eukaryotic orthologs. The constructed 3D model predicted that mouse …
Identification of key carcinogenic genes in Wilms' tumor.
He S, Yang L, Xiao Z, Tang K, Xu D. He S, et al. Genes Genet Syst. 2021 Oct 9;96(3):141-149. doi: 10.1266/ggs.21-00015. Epub 2021 Aug 1. Genes Genet Syst. 2021. PMID: 34334530 Free article.
In the PPI network, hub positions included COL5A1, COL4A1, ARPP21, SPARCL1, CD86, LY96 and PPP1R12B. The top DEGs (ARPP21, SYNPO, PRRC2B, PPP1R12B, EFCAB2 and LY96) were selected for survival analysis, and they consistently showed a significantly positive correlation with …
In the PPI network, hub positions included COL5A1, COL4A1, ARPP21, SPARCL1, CD86, LY96 and PPP1R12B. The top DEGs (ARPP21, SYNPO, PRRC2B, PP …
Emerging Role of Circular RNAs as Potential Biomarkers for the Diagnosis of Human Diseases.
Ojha R, Nandani R, Chatterjee N, Prajapati VK. Ojha R, et al. Adv Exp Med Biol. 2018;1087:141-157. doi: 10.1007/978-981-13-1426-1_12. Adv Exp Med Biol. 2018. PMID: 30259364 Review.
Furthermore, it has been observed that circRNAs are abundantly present within the mammalian brain tissues. In epileptic condition, Circ-EFCAB2 was observed to get notably upregulated within patients. Taking the above conditions into consideration, circular RNAs have proven …
Furthermore, it has been observed that circRNAs are abundantly present within the mammalian brain tissues. In epileptic condition, Circ-E …
Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
Lu Y, Kweon SS, Tanikawa C, Jia WH, Xiang YB, Cai Q, Zeng C, Schmit SL, Shin A, Matsuo K, Jee SH, Kim DH, Kim J, Wen W, Shi J, Guo X, Li B, Wang N, Zhang B, Li X, Shin MH, Li HL, Ren Z, Oh JH, Oze I, Ahn YO, Jung KJ, Conti DV, Schumacher FR, Rennert G, Jenkins MA, Campbell PT, Hoffmeister M, Casey G, Gruber SB, Gao J, Gao YT, Pan ZZ, Kamatani Y, Zeng YX, Shu XO, Long J, Matsuda K, Zheng W. Lu Y, et al. Gastroenterology. 2019 Apr;156(5):1455-1466. doi: 10.1053/j.gastro.2018.11.066. Epub 2018 Dec 6. Gastroenterology. 2019. PMID: 30529582 Free PMC article.
For 8 of the 13 associated loci, the variants with the highest levels of significant association were located inside or near the protein-coding genes L1TD1, EFCAB2, PPP1R21, SLCO2A1, HLA-G, NOTCH4, DENND5B, and GNAS. For other intergenic loci, we provided evidence for the …
For 8 of the 13 associated loci, the variants with the highest levels of significant association were located inside or near the protein-cod …
Evaluation of autoantibody signatures in meningioma patients using human proteome arrays.
Gupta S, Mukherjee S, Syed P, Pandala NG, Choudhary S, Singh VA, Singh N, Zhu H, Epari S, Noronha SB, Moiyadi A, Srivastava S. Gupta S, et al. Oncotarget. 2017 Apr 10;8(35):58443-58456. doi: 10.18632/oncotarget.16997. eCollection 2017 Aug 29. Oncotarget. 2017. PMID: 28938569 Free PMC article.
This comprehensive proteomics based investigation revealed the dysregulation of 489 and 104 proteins in grades I and II of meningioma, respectively, along with the enrichment of several signalling pathways, which might play a crucial role in the manifestation of the disease. Auto …
This comprehensive proteomics based investigation revealed the dysregulation of 489 and 104 proteins in grades I and II of meningioma, respe …
High-Throughput Data of Circular RNA Profiles in Human Temporal Cortex Tissue Reveals Novel Insights into Temporal Lobe Epilepsy.
Li J, Lin H, Sun Z, Kong G, Yan X, Wang Y, Wang X, Wen Y, Liu X, Zheng H, Jia M, Shi Z, Xu R, Yang S, Yuan F. Li J, et al. Cell Physiol Biochem. 2018;45(2):677-691. doi: 10.1159/000487161. Epub 2018 Jan 31. Cell Physiol Biochem. 2018. PMID: 29428937 Free article.
Eight circRNAs were validated by real-time PCR. Remarkably, circ-EFCAB2 was intensely up-regulated, while circ-DROSHA expression was significantly lower in the TLE group than in the non-TLE group (P<0.05). ...CONCLUSIONS: The dysregulations of circRNAs may reflect the p …
Eight circRNAs were validated by real-time PCR. Remarkably, circ-EFCAB2 was intensely up-regulated, while circ-DROSHA expression was …
Understanding the functional role of genistein in the bone differentiation in mouse osteoblastic cell line MC3T3-E1 by RNA-seq analysis.
Kim M, Lim J, Lee JH, Lee KM, Kim S, Park KW, Nho CW, Cho YS. Kim M, et al. Sci Rep. 2018 Feb 19;8(1):3257. doi: 10.1038/s41598-018-21601-9. Sci Rep. 2018. PMID: 29459627 Free PMC article.
These siRNA knockdown experiments (of the DEGs validated by real-time qPCR) demonstrated that two up-regulated genes (Ereg and Efcab2) enhance osteoblastic cell differentiation, while three down-regulated genes (Hrc, Gli, and Ifitm5) suppress the differentiation. ...
These siRNA knockdown experiments (of the DEGs validated by real-time qPCR) demonstrated that two up-regulated genes (Ereg and Efcab2 …
Identification of gender-specific candidate genes that influence bone microarchitecture in chromosome 1.
Mohan S, Hu Y, Edderkaoui B. Mohan S, et al. Calcif Tissue Int. 2013 Apr;92(4):362-71. doi: 10.1007/s00223-012-9687-1. Epub 2012 Dec 22. Calcif Tissue Int. 2013. PMID: 23263656 Free PMC article.
To identify the gender candidate genes, we determined the polymorphisms between B6 and CAST within the BMD1-4 locus and performed gene expression profiling. We identified EF-hand calcium binding domain (Efcab2), consortin, connexin sorting protein (Cnst), and presenilin 2 …
To identify the gender candidate genes, we determined the polymorphisms between B6 and CAST within the BMD1-4 locus and performed gene expre …
Maternal interchromosomal insertional translocation leading to 1q43-q44 deletion and duplication in two siblings.
Luo A, Cheng D, Yuan S, Li H, Du J, Zhang Y, Yang C, Lin G, Zhang W, Tan YQ. Luo A, et al. Mol Cytogenet. 2018 Apr 4;11:24. doi: 10.1186/s13039-018-0371-7. eCollection 2018. Mol Cytogenet. 2018. PMID: 29636822 Free PMC article.
Moreover, Sanger sequencing was used to assist the mapping of the breakpoints and the final validation of those breakpoints. The breakpoint on chromosome 1 disrupted the EFCAB2 gene in the first intron, and the breakpoint on chromosome 14 disrupted the PRKCH gene within th …
Moreover, Sanger sequencing was used to assist the mapping of the breakpoints and the final validation of those breakpoints. The breakpoint …
Genetic association of gemcitabine/carboplatin-induced leukopenia and neutropenia in non-small cell lung cancer patients using whole-exome sequencing.
Svedberg A, Björn N, Sigurgeirsson B, Pradhananga S, Brandén E, Koyi H, Lewensohn R, De Petris L, Apellániz-Ruiz M, Rodríguez-Antona C, Lundeberg J, Gréen H. Svedberg A, et al. Lung Cancer. 2020 Sep;147:106-114. doi: 10.1016/j.lungcan.2020.07.005. Epub 2020 Jul 12. Lung Cancer. 2020. PMID: 32683206 Free article.
Of these SNVS 20 and 19 were partially validated for leukopenia and neutropenia, respectively. The genes SVIL (p = 2.48E-06) and EFCAB2 (p = 4.63E-06) were significantly associated with leukopenia contain the partially validated SNVs rs3740003, rs10160013, rs1547169, rs109 …
Of these SNVS 20 and 19 were partially validated for leukopenia and neutropenia, respectively. The genes SVIL (p = 2.48E-06) and EFCAB2 …
11 results