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Page 1
EFEMP2-Related Cutis Laxa.
Loeys B, De Paepe A, Urban Z. Loeys B, et al. 2011 May 12 [updated 2023 Jun 15]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2011 May 12 [updated 2023 Jun 15]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 21563328 Free Books & Documents. Review.
Severity ranges from perinatal lethality as a result of cardiopulmonary failure to manifestations limited to the vascular and craniofacial systems. DIAGNOSIS/TESTING: The diagnosis of EFEMP2-related cutis laxa is established in a proband with suggestive findings and bialle …
Severity ranges from perinatal lethality as a result of cardiopulmonary failure to manifestations limited to the vascular and craniofacial s …
EFEMP2 suppresses epithelial-mesenchymal transition via Wnt/beta-catenin signaling pathway in human bladder cancer.
Zhou Q, Chen S, Lu M, Luo Y, Wang G, Xiao Y, Ju L, Wang X. Zhou Q, et al. Int J Biol Sci. 2019 Aug 8;15(10):2139-2155. doi: 10.7150/ijbs.35541. eCollection 2019. Int J Biol Sci. 2019. PMID: 31592144 Free PMC article.
However, influenced by the tumor microenvironment, EFEMP2 played different roles in different tumors. The current study focused on exploring the role of EFEMP2 in bladder cancer (BCa). ...And we found a negative correlation between EFEMP2 expression and high …
However, influenced by the tumor microenvironment, EFEMP2 played different roles in different tumors. The current study focused on ex …
EFEMP2 upregulates PD-L1 expression via EGFR/ERK1/2/c-Jun signaling to promote the invasion of ovarian cancer cells.
Shen X, Jin X, Fang S, Chen J. Shen X, et al. Cell Mol Biol Lett. 2023 Jul 7;28(1):53. doi: 10.1186/s11658-023-00471-8. Cell Mol Biol Lett. 2023. PMID: 37420173 Free PMC article.
Similar to EFEMP2, PD-L1 was also highly expressed in aggressive cells and had the ability to promote the invasion and metastasis of ovarian cancer cells both in vitro and in vivo, and PD-L1 upregulation was partly caused by EFEMP2 activation. ...CONCLUSION: EFEM …
Similar to EFEMP2, PD-L1 was also highly expressed in aggressive cells and had the ability to promote the invasion and metastasis of …
EFEMP2 Inhibits Breast Cancer Invasion And Metastasis In Vitro And In Vivo.
Kang N, Zhou J, Xu J, Zhou D, Shi W. Kang N, et al. Onco Targets Ther. 2019 Oct 30;12:8915-8933. doi: 10.2147/OTT.S221219. eCollection 2019. Onco Targets Ther. 2019. PMID: 31802903 Free PMC article.
Lentiviral vector with EFEMP2 cDNA was constructed and used to infect breast cancer cell lines to investigate the effects of EFEMP2 on the biological behavior of breast cancer cells by functional in vitro and in vivo assays. RESULTS: Down-regulated EFEMP2 exp …
Lentiviral vector with EFEMP2 cDNA was constructed and used to infect breast cancer cell lines to investigate the effects of EFEMP …
EFEMP2 increases the invasion ability of cervical cancer cells by promoting EMT via the Raf/MEK/ERK signaling pathway.
Li N, Ji GX, Yang ZY. Li N, et al. Neoplasma. 2022 Sep;69(5):1185-1197. doi: 10.4149/neo_2022_220117N74. Epub 2022 Aug 24. Neoplasma. 2022. PMID: 36004647
EFEMP2 has been reported as a candidate oncogene. To investigate the role of EFEMP2 in cervical cancer cell proliferation and invasion, the mRNA and protein expressions of EFEMP2 in 5 different cervical cancer cell lines were detected. ...The results revealed …
EFEMP2 has been reported as a candidate oncogene. To investigate the role of EFEMP2 in cervical cancer cell proliferation and …
EFEMP2 indicates assembly of M0 macrophage and more malignant phenotypes of glioma.
Huang L, Wang Z, Chang Y, Wang K, Kang X, Huang R, Zhang Y, Chen J, Zeng F, Wu F, Zhao Z, Li G, Huang H, Jiang T, Hu H. Huang L, et al. Aging (Albany NY). 2020 May 12;12(9):8397-8412. doi: 10.18632/aging.103147. Epub 2020 May 12. Aging (Albany NY). 2020. PMID: 32396873 Free PMC article.
EFEMP2 exhibited a remarkable preference of intercellular expression. ...Moreover, EFEMP2 expression level was remarkably correlated with immunological responses. ...
EFEMP2 exhibited a remarkable preference of intercellular expression. ...Moreover, EFEMP2 expression level was remarkably corr …
EFEMP2 Suppresses the Invasion of Lung Cancer Cells by Inhibiting Epithelial-Mesenchymal Transition (EMT) and Down-Regulating MMPs.
Song L, Li XX, Liu XY, Wang Z, Yu Y, Shi M, Jiang B, He XP. Song L, et al. Onco Targets Ther. 2020 Feb 14;13:1375-1396. doi: 10.2147/OTT.S236111. eCollection 2020. Onco Targets Ther. 2020. PMID: 32110039 Free PMC article.
CONCLUSION: The low expression of EFEMP2 was detected in lung cancer and was positively correlated with the poor prognosis of patients. EFEMP2 was a tumor suppressor gene that inhibited the progress of lung cancer, which suggested a new research objective for the fu …
CONCLUSION: The low expression of EFEMP2 was detected in lung cancer and was positively correlated with the poor prognosis of patient …
EFEMP2 promotes colon cancer cell invasion and growth through the ERK1/2 signaling pathway.
Zhao J, Xu J, Zhao J, Zhang R. Zhao J, et al. Int J Clin Exp Pathol. 2019 Mar 1;12(3):851-856. eCollection 2019. Int J Clin Exp Pathol. 2019. PMID: 31933893 Free PMC article.
However, the function of EFEMP2 in colon cancer remains unknown. In this study, we found that EFEMP2 was highly expressed in colon cancer cells. ...Therapies targeting EFEMP2 may be an effective strategy for treatment of colon cancer....
However, the function of EFEMP2 in colon cancer remains unknown. In this study, we found that EFEMP2 was highly expressed in c …
EFEMP2 Mediates GALNT14-Dependent Breast Cancer Cell Invasion.
Zuo T, Shan J, Liu Y, Xie R, Yu X, Wu C. Zuo T, et al. Transl Oncol. 2018 Apr;11(2):346-352. doi: 10.1016/j.tranon.2018.01.021. Epub 2018 Feb 8. Transl Oncol. 2018. PMID: 29428518 Free PMC article.
Here, using yeast two hybrid, we find that EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) interacts with GALNT14. Both in vitro and in vivo binding assays show that EFEMP2 is associated with GALNT14. Moreover, we find that GALNT14 mediates glyco …
Here, using yeast two hybrid, we find that EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) interacts with GALNT14 …
Sevoflurane-Induced miR-211-5p Promotes Neuronal Apoptosis by Inhibiting Efemp2.
Shen Y, Zhou T, Liu X, Liu Y, Li Y, Zeng D, Zhong W, Zhang M. Shen Y, et al. ASN Neuro. 2021 Jan-Dec;13:17590914211035036. doi: 10.1177/17590914211035036. ASN Neuro. 2021. PMID: 34730432 Free PMC article.
Here, we found that sevoflurane upregulated miR-211-5p and downregulated EGF-Containing Fibulin Extracellular Matrix Protein 2 (Efemp2, Fibulin-4) levels in vitro and in vivo. Sevoflurane's effect on miR-211-5p expression was based on enhancing primary miR-211 transcriptio …
Here, we found that sevoflurane upregulated miR-211-5p and downregulated EGF-Containing Fibulin Extracellular Matrix Protein 2 (Efemp2 …
154 results