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Page 1
Androgen upregulates the palmitoylation of eIF3L in human prostate LNCaP cells.
Cui L, Liu M, Lai S, Hou H, Diao T, Zhang D, Wang M, Zhang Y, Wang J. Cui L, et al. Onco Targets Ther. 2019 Jun 5;12:4451-4459. doi: 10.2147/OTT.S193480. eCollection 2019. Onco Targets Ther. 2019. PMID: 31239713 Free PMC article.
Results: We identified 4351 unique peptides corresponding to 835 proteins, among them a number of these identified proteins were palmitoylated proteins, particularly eIF3L. Androgen treatment significantly increased the palmitoylation level of eIF3L, an individual s …
Results: We identified 4351 unique peptides corresponding to 835 proteins, among them a number of these identified proteins were palmitoylat …
Biophysical and structural characterization of the recombinant human eIF3L.
Morais AT, Meza AN, Araújo GC, Vidotto A, Souza FP, Fossey MA, Murakami MT, Nogueira ML. Morais AT, et al. Protein Pept Lett. 2014;21(1):56-62. doi: 10.2174/09298665113209990084. Protein Pept Lett. 2014. PMID: 23919378
Considering the importance of eIF3L in a diversity of cellular functions, we have produced the recombinant full-length eIF3L protein in Escherichia coli and performed spectroscopic and in silico analyses to gain insights into its hydrodynamic behavior and structure. …
Considering the importance of eIF3L in a diversity of cellular functions, we have produced the recombinant full-length eIF3L p …
Mutations in Nonessential eIF3k and eIF3l Genes Confer Lifespan Extension and Enhanced Resistance to ER Stress in Caenorhabditis elegans.
Cattie DJ, Richardson CE, Reddy KC, Ness-Cohn EM, Droste R, Thompson MK, Gilbert WV, Kim DH. Cattie DJ, et al. PLoS Genet. 2016 Sep 30;12(9):e1006326. doi: 10.1371/journal.pgen.1006326. eCollection 2016 Sep. PLoS Genet. 2016. PMID: 27690135 Free PMC article.
Here, we show that loss-of-function mutations in the genes encoding the conserved eIF3k and eIF3l subunits of the translation initiation complex eIF3 result in a 40% extension in lifespan and enhanced resistance to endoplasmic reticulum (ER) stress in Caenorhabditis elegan …
Here, we show that loss-of-function mutations in the genes encoding the conserved eIF3k and eIF3l subunits of the translation initiat …
eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content.
Duan H, Zhang S, Zarai Y, Öllinger R, Wu Y, Sun L, Hu C, He Y, Tian G, Rad R, Kong X, Cheng Y, Tuller T, Wolf DA. Duan H, et al. EMBO J. 2023 Jun 15;42(12):e112362. doi: 10.15252/embj.2022112362. Epub 2023 May 8. EMBO J. 2023. PMID: 37155573 Free PMC article.
Whereas ectopic expression of RPS15A mimicked the anabolic effects of eIF3k depletion, disruption of eIF3 binding to the 5'-UTR of RSP15A mRNA negated them. eIF3k and eIF3l are selectively downregulated in response to endoplasmic reticulum and oxidative stress. ...
Whereas ectopic expression of RPS15A mimicked the anabolic effects of eIF3k depletion, disruption of eIF3 binding to the 5'-UTR of RSP15A mR …
The eukaryotic translation initiation factor 3 subunit L protein interacts with Flavivirus NS5 and may modulate yellow fever virus replication.
Morais ATs, Terzian AC, Duarte DV, Bronzoni RV, Madrid MC, Gavioli AF, Gil LH, Oliveira AG, Zanelli CF, Valentini SR, Rahal P, Nogueira ML. Morais ATs, et al. Virol J. 2013 Jun 22;10:205. doi: 10.1186/1743-422X-10-205. Virol J. 2013. PMID: 23800076 Free PMC article.
The significance of eIF3L for YFV replication was investigated using eIF3L overexpression and RNA interference. ...CONCLUSIONS: Although the precise function of eIF3L on interactions with viral proteins is not entirely understood, these results indicate an in …
The significance of eIF3L for YFV replication was investigated using eIF3L overexpression and RNA interference. ...CONCLUSIONS …
Evaluation of identification methods for cryptic Bactrocera dorsalis (Diptera: Tephritidae) specimens: combining morphological and molecular techniques.
Charbonnel E, Chapuis MP, Taddei A, Schutze MK, Starkie ML, Benoit L, Mouttet R, Ouvrard D. Charbonnel E, et al. J Econ Entomol. 2023 Dec 11;116(6):2193-2200. doi: 10.1093/jee/toad178. J Econ Entomol. 2023. PMID: 37824174 Free PMC article.
Specimens were then subjected to DNA sequence analyses of the COI mitochondrial barcode and the EIF3L nuclear marker to evaluate the potential for molecular identification, in particular for specimens for which morphological identification was inconclusive. ...Critical int …
Specimens were then subjected to DNA sequence analyses of the COI mitochondrial barcode and the EIF3L nuclear marker to evaluate the …
Loop-mediated isothermal amplification (LAMP) assays for detection of the New Guinea fruit fly Bactrocera trivialis (Drew) (Diptera: Tephritidae).
Starkie ML, Fowler EV, Zhu X, Agarwal A, Rako L, Schneider IC, Schutze MK, Royer JE, Gopurenko D, Gillespie P, Blacket MJ. Starkie ML, et al. Sci Rep. 2022 Jul 23;12(1):12602. doi: 10.1038/s41598-022-16901-0. Sci Rep. 2022. PMID: 35871253 Free PMC article.
We developed LAMP assays targeting cytochrome c oxidase subunit I (COI) and Eukaryotic Translation Initiation Factor 3 Subunit L (EIF3L); both assays detected B. trivialis within 25 min. The BtrivCOI and BtrivEIF3L assay anneal derivatives were 82.7 0.8 C and 83.3 1.3 C, r …
We developed LAMP assays targeting cytochrome c oxidase subunit I (COI) and Eukaryotic Translation Initiation Factor 3 Subunit L (EIF3L
Reconstitution of eukaryotic translation initiation factor 3 by co-expression of the subunits in a human cell-derived in vitro protein synthesis system.
Masutani M, Machida K, Kobayashi T, Yokoyama S, Imataka H. Masutani M, et al. Protein Expr Purif. 2013 Jan;87(1):5-10. doi: 10.1016/j.pep.2012.10.001. Epub 2012 Oct 11. Protein Expr Purif. 2013. PMID: 23063735
After incubation for several hours, the eIF3 complex was purified through tag-dependent affinity chromatography. When eIF3l, one of the nonessential subunits of eIF3, was not expressed, the eIF3 complex that was devoid of eIF3l was still obtained. Both the 11 subuni …
After incubation for several hours, the eIF3 complex was purified through tag-dependent affinity chromatography. When eIF3l, one of t …
Identification of host cell proteins that interact with the M protein of porcine epidemic diarrhea virus.
Wang R, Yu R, Chen B, Si F, Wang J, Xie C, Men C, Dong S, Li Z. Wang R, et al. Vet Microbiol. 2020 Jul;246:108729. doi: 10.1016/j.vetmic.2020.108729. Epub 2020 May 21. Vet Microbiol. 2020. PMID: 32605758 Free PMC article.
In addition, interaction between translation initiation factor 3(eIF3L) and M protein was validated by Co-IP. Down-regulation of eIF3L expression significantly increased viral production, which suggests that eIF3L could be a negative regulator in PEDV replica …
In addition, interaction between translation initiation factor 3(eIF3L) and M protein was validated by Co-IP. Down-regulation of e
Proteomic elucidation of the targets and primary functions of the picornavirus 2A protease.
Serganov AA, Udi Y, Stein ME, Patel V, Fridy PC, Rice CM, Saeed M, Jacobs EY, Chait BT, Rout MP. Serganov AA, et al. J Biol Chem. 2022 Jun;298(6):101882. doi: 10.1016/j.jbc.2022.101882. Epub 2022 Mar 31. J Biol Chem. 2022. PMID: 35367208 Free PMC article.
The protease appears to employ two different cleavage mechanisms; it likely interacts with eIF3L, utilizing the eIF3 complex to proteolytically access the eIF4G protein but also directly binds and degrades Nup98. ...
The protease appears to employ two different cleavage mechanisms; it likely interacts with eIF3L, utilizing the eIF3 complex to prote …
28 results