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Design, synthesis and bioactivity study on oxygen-heterocyclic-based pyran analogues as effective P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell.
Abd El-Wahab AHF, Borik RMA, Al-Dies AM, Fouda AM, Mohamed HM, El-Eisawy RA, Mora A, El-Nassag MAA, Abd Elhady AM, Elhenawy AA, El-Agrody AM. Abd El-Wahab AHF, et al. Among authors: el eisawy ra. Sci Rep. 2024 Mar 31;14(1):7589. doi: 10.1038/s41598-024-56197-w. Sci Rep. 2024. PMID: 38555345 Free PMC article.
Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the P-glycoprotein expression levels.
Al-Harbi LM, Al-Harbi EA, Okasha RM, El-Eisawy RA, El-Nassag MAA, Mohamed HM, Fouda AM, Elhenawy AA, Mora A, El-Agrody AM, El-Mawgoud HKA. Al-Harbi LM, et al. Among authors: el eisawy ra. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2155814. doi: 10.1080/14756366.2022.2155814. J Enzyme Inhib Med Chem. 2023. PMID: 36662632 Free PMC article.
Synthesis of 9-Hydroxy-1H-Benzo[f]chromene Derivatives with Effective Cytotoxic Activity on MCF7/ADR, P-Glycoprotein Inhibitors, Cell Cycle Arrest and Apoptosis Effects.
Albalawi FF, El-Nassag MAA, El-Eisawy RA, Mohamed MBI, Fouda AM, Afifi TH, Elhenawy AA, Mora A, El-Agrody AM, El-Mawgoud HKA. Albalawi FF, et al. Among authors: el eisawy ra. Int J Mol Sci. 2022 Dec 20;24(1):49. doi: 10.3390/ijms24010049. Int J Mol Sci. 2022. PMID: 36613493 Free PMC article.