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Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV-2 and Potential Mechanisms.
Puhl AC, Fritch EJ, Lane TR, Tse LV, Yount BL, Sacramento CQ, Fintelman-Rodrigues N, Tavella TA, Maranhão Costa FT, Weston S, Logue J, Frieman M, Premkumar L, Pearce KH, Hurst BL, Andrade CH, Levi JA, Johnson NJ, Kisthardt SC, Scholle F, Souza TML, Moorman NJ, Baric RS, Madrid PB, Ekins S. Puhl AC, et al. ACS Omega. 2021 Mar 10;6(11):7454-7468. doi: 10.1021/acsomega.0c05996. eCollection 2021 Mar 23. ACS Omega. 2021. PMID: 33778258 Free PMC article.
One of the key approaches that has been widely applied in an effort to speed up the translation of drugs is drug repurposing. A few drugs have shown in vitro activity against Ebola viruses and demonstrated activity against SARS-CoV-2 in vivo. ...We have previously repurpos …
One of the key approaches that has been widely applied in an effort to speed up the translation of drugs is drug repurposing. A few drugs ha …
Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine and Pyronaridine: In vitro Activity Against SARS-CoV-2 and Potential Mechanisms.
Puhl AC, Fritch EJ, Lane TR, Tse LV, Yount BL, Sacramento CQ, Tavella TA, Costa FTM, Weston S, Logue J, Frieman M, Premkumar L, Pearce KH, Hurst BL, Andrade CH, Levi JA, Johnson NJ, Kisthardt SC, Scholle F, Souza TML, Moorman NJ, Baric RS, Madrid P, Ekins S. Puhl AC, et al. bioRxiv [Preprint]. 2020 Dec 2:2020.12.01.407361. doi: 10.1101/2020.12.01.407361. bioRxiv. 2020. PMID: 33299990 Free PMC article. Updated. Preprint.
One of the key approaches that has been widely applied in an effort to speed up the translation of drugs is drug repurposing. A few drugs have shown in vitro activity against Ebola virus and demonstrated activity against SARS-CoV-2 in vivo . ...We have previously repurpose …
One of the key approaches that has been widely applied in an effort to speed up the translation of drugs is drug repurposing. A few drugs ha …
Toward the Target: Tilorone, Quinacrine, and Pyronaridine Bind to Ebola Virus Glycoprotein.
Lane TR, Ekins S. Lane TR, et al. ACS Med Chem Lett. 2020 Jul 23;11(8):1653-1658. doi: 10.1021/acsmedchemlett.0c00298. eCollection 2020 Aug 13. ACS Med Chem Lett. 2020. PMID: 32832035 Free PMC article.
Pyronaridine, tilorone, and quinacrine were recently identified by a machine learning model and demonstrated in vitro and in vivo activity against Ebola virus (EBOV) and represent viable candidates for drug repurposing. ...These three structures provide more insight into t …
Pyronaridine, tilorone, and quinacrine were recently identified by a machine learning model and demonstrated in vitro and in vivo activity a …
Repurposing Pyramax, quinacrine and tilorone as treatments for Ebola virus disease.
Lane TR, Dyall J, Mercer L, Goodin C, Foil DH, Zhou H, Postnikova E, Liang JY, Holbrook MR, Madrid PB, Ekins S. Lane TR, et al. Antiviral Res. 2020 Oct;182:104908. doi: 10.1016/j.antiviral.2020.104908. Epub 2020 Aug 13. Antiviral Res. 2020. PMID: 32798602 Free PMC article.
We have recently identified three molecules (tilorone, quinacrine and pyronaridine tetraphosphate) which all demonstrated efficacy in the mouse model of infection with mouse-adapted Ebola virus (EBOV) model of disease and had similar in vitro inhibition of an Ebola …
We have recently identified three molecules (tilorone, quinacrine and pyronaridine tetraphosphate) which all demonstrated efficacy in the mo …
Small molecules with antiviral activity against the Ebola virus.
Litterman N, Lipinski C, Ekins S. Litterman N, et al. F1000Res. 2015 Feb 9;4:38. doi: 10.12688/f1000research.6120.1. eCollection 2015. F1000Res. 2015. PMID: 25713700 Free PMC article. Review.
The recent outbreak of the Ebola virus in West Africa has highlighted the clear shortage of broad-spectrum antiviral drugs for emerging viruses. ...These molecules are in addition to the few new antivirals that have been tested in Ebola patients but were not origina …
The recent outbreak of the Ebola virus in West Africa has highlighted the clear shortage of broad-spectrum antiviral drugs for emergi …
High Throughput and Computational Repurposing for Neglected Diseases.
Hernandez HW, Soeung M, Zorn KM, Ashoura N, Mottin M, Andrade CH, Caffrey CR, de Siqueira-Neto JL, Ekins S. Hernandez HW, et al. Pharm Res. 2018 Dec 17;36(2):27. doi: 10.1007/s11095-018-2558-3. Pharm Res. 2018. PMID: 30560386 Free PMC article. Review.
Pyronaridine Protects against SARS-CoV-2 Infection in Mouse.
Puhl AC, Gomes GF, Damasceno S, Godoy AS, Noske GD, Nakamura AM, Gawriljuk VO, Fernandes RS, Monakhova N, Riabova O, Lane TR, Makarov V, Veras FP, Batah SS, Fabro AT, Oliva G, Cunha FQ, Alves-Filho JC, Cunha TM, Ekins S. Puhl AC, et al. ACS Infect Dis. 2022 Jun 10;8(6):1147-1160. doi: 10.1021/acsinfecdis.2c00091. Epub 2022 May 24. ACS Infect Dis. 2022. PMID: 35609344
One of these is remdesivir, which was originally repurposed from its use against Ebola. We evaluated three molecules we had previously identified computationally with antiviral activity against Ebola and Marburg and identified pyronaridine, which inhibited the SARS- …
One of these is remdesivir, which was originally repurposed from its use against Ebola. We evaluated three molecules we had previousl …
Transporter Inhibition Profile for the Antivirals Tilorone, Quinacrine and Pyronaridine.
Vignaux PA, Lane TR, Puhl AC, Hau RK, Wright SH, Cherrington NJ, Ekins S. Vignaux PA, et al. ACS Omega. 2023 Mar 24;8(13):12532-12537. doi: 10.1021/acsomega.3c00724. eCollection 2023 Apr 4. ACS Omega. 2023. PMID: 37033868 Free PMC article.
Pyronaridine, tilorone and quinacrine are cationic molecules that have in vitro activity against Ebola, SARS-CoV-2 and other viruses. All three molecules have also demonstrated in vivo activity against Ebola in mice, while pyronaridine showed in vivo efficacy agains …
Pyronaridine, tilorone and quinacrine are cationic molecules that have in vitro activity against Ebola, SARS-CoV-2 and other viruses. …
Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses.
Ekins S, Madrid PB. Ekins S, et al. Antimicrob Agents Chemother. 2020 Apr 21;64(5):e00440-20. doi: 10.1128/AAC.00440-20. Print 2020 Apr 21. Antimicrob Agents Chemother. 2020. PMID: 32205350 Free PMC article.
We have recently described activity in vitro and in vivo against the Ebola virus. After a broad screening of additional viruses, we now describe in vitro activity against Chikungunya virus (CHIK) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV)....
We have recently described activity in vitro and in vivo against the Ebola virus. After a broad screening of additional viruses, we n …
Pyronaridine tetraphosphate efficacy against Ebola virus infection in guinea pig.
Lane TR, Massey C, Comer JE, Freiberg AN, Zhou H, Dyall J, Holbrook MR, Anantpadma M, Davey RA, Madrid PB, Ekins S. Lane TR, et al. Antiviral Res. 2020 Sep;181:104863. doi: 10.1016/j.antiviral.2020.104863. Epub 2020 Jul 16. Antiviral Res. 2020. PMID: 32682926 Free PMC article.
The recent outbreaks of the Ebola virus (EBOV) in Africa have brought global visibility to the shortage of available therapeutic options to treat patients infected with this or closely related viruses. We have recently computationally identified three molecules which have …
The recent outbreaks of the Ebola virus (EBOV) in Africa have brought global visibility to the shortage of available therapeutic opti …
25 results