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Year Number of Results
1996 3
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1998 2
1999 5
2000 2
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2002 6
2003 8
2004 8
2005 8
2006 11
2007 7
2008 5
2009 13
2010 10
2011 20
2012 14
2013 8
2014 12
2015 16
2016 19
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2019 15
2020 15
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262 results

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Page 1
FGF19-mediated ELF4 overexpression promotes colorectal cancer metastasis through transactivating FGFR4 and SRC.
Chen X, Chen J, Feng W, Huang W, Wang G, Sun M, Luo X, Wang Y, Nie Y, Fan D, Wu K, Xia L. Chen X, et al. Theranostics. 2023 Feb 22;13(4):1401-1418. doi: 10.7150/thno.82269. eCollection 2023. Theranostics. 2023. PMID: 36923538 Free PMC article.
ELF4 expression was also an independent predictor of poor prognosis. ...Fibroblast growth factor 19 (FGF19) upregulated ELF4 expression through the ERK1/2/SP1 axis. Clinically, ELF4 expression had a positive correlation with FGF19, FGFR4 and SRC, and CRC pati …
ELF4 expression was also an independent predictor of poor prognosis. ...Fibroblast growth factor 19 (FGF19) upregulated ELF4 e …
Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation.
Tyler PM, Bucklin ML, Zhao M, Maher TJ, Rice AJ, Ji W, Warner N, Pan J, Morotti R, McCarthy P, Griffiths A, van Rossum AMC, Hollink IHIM, Dalm VASH, Catanzaro J, Lakhani SA, Muise AM, Lucas CL. Tyler PM, et al. Nat Immunol. 2021 Sep;22(9):1118-1126. doi: 10.1038/s41590-021-00984-4. Epub 2021 Jul 29. Nat Immunol. 2021. PMID: 34326534 Free PMC article.
Using cells from patients and newly generated mouse models, we uncovered ELF4-mutant macrophages having hyperinflammatory responses to a range of innate stimuli. ...Blockade of Trem1 reversed inflammation and intestine pathology after in vivo lipopolysaccharide challenge i …
Using cells from patients and newly generated mouse models, we uncovered ELF4-mutant macrophages having hyperinflammatory responses t …
An ELF4 hypomorphic variant results in NK cell deficiency.
Salinas SA, Mace EM, Conte MI, Park CS, Li Y, Rosario-Sepulveda JI, Mahapatra S, Moore EK, Hernandez ER, Chinn IK, Reed AE, Lee BJ, Frumovitz A, Gibbs RA, Posey JE, Forbes Satter LR, Thatayatikom A, Allenspach EJ, Wensel TG, Lupski JR, Lacorazza HD, Orange JS. Salinas SA, et al. JCI Insight. 2022 Dec 8;7(23):e155481. doi: 10.1172/jci.insight.155481. JCI Insight. 2022. PMID: 36477361 Free PMC article.
An individual with recurrent viral infections and mild hypogammaglobulinemia was identified to have an X-linked damaging variant in the transcription factor gene ELF4. The variant does not decrease expression but disrupts ELF4 protein interactions and DNA binding, r …
An individual with recurrent viral infections and mild hypogammaglobulinemia was identified to have an X-linked damaging variant in the tran …
ELF4 is a critical component of a miRNA-transcription factor network and is a bridge regulator of glioblastoma receptor signaling and lipid dynamics.
Kosti A, Chiou J, Guardia GDA, Lei X, Balinda H, Landry T, Lu X, Qiao M, Gilbert A, Brenner A, Galante PAF, Tiziani S, Penalva LOF. Kosti A, et al. Neuro Oncol. 2023 Mar 14;25(3):459-470. doi: 10.1093/neuonc/noac179. Neuro Oncol. 2023. PMID: 35862252 Free PMC article.
We characterized ELF4's mechanism of action via genomic and lipidomic analyses. A MAPK reporter assay verified ELF4's impact on MAPK signaling, and qRT-PCR and western blotting were used to corroborate ELF4 regulatory role on most relevant target genes. ...Fu …
We characterized ELF4's mechanism of action via genomic and lipidomic analyses. A MAPK reporter assay verified ELF4's impact o …
Roles and regulations of the ETS transcription factor ELF4/MEF.
Suico MA, Shuto T, Kai H. Suico MA, et al. J Mol Cell Biol. 2017 Jun 1;9(3):168-177. doi: 10.1093/jmcb/mjw051. J Mol Cell Biol. 2017. PMID: 27932483 Free PMC article. Review.
Mutations in ELF4 cause aberrant interactions and induce downstream processes that may lead to diseased cells. Knowing how ELF4 impinges on certain cellular processes and how it is regulated in the cells can lead to a better understanding of the physiological and pa …
Mutations in ELF4 cause aberrant interactions and induce downstream processes that may lead to diseased cells. Knowing how ELF4 …
Intestinal ELF4 Deletion Exacerbates Alcoholic Liver Disease by Disrupting Gut Homeostasis.
Liu T, Yu H, Zhang Z, Xie Y, Yang L, You F. Liu T, et al. Int J Mol Sci. 2022 Apr 27;23(9):4825. doi: 10.3390/ijms23094825. Int J Mol Sci. 2022. PMID: 35563234 Free PMC article.
Intestinal ELF4 deficiency resulted in dysfunction of the intestinal barrier. ...The LPS increased in Elf4(-/-) mice and was the most important differential metabolite between Elf4(-/-) mice and WT mice. ...
Intestinal ELF4 deficiency resulted in dysfunction of the intestinal barrier. ...The LPS increased in Elf4(-/-) mice and was t …
ELF4 is critical to zygotic gene activation and epigenetic reprogramming during early embryonic development in pigs.
Shi L, Zhai Y, Zhao Y, Kong X, Zhang D, Yu H, Li Z. Shi L, et al. Front Vet Sci. 2022 Jul 19;9:954601. doi: 10.3389/fvets.2022.954601. eCollection 2022. Front Vet Sci. 2022. PMID: 35928113 Free PMC article.

The embryonic developmental competency and blastocyst quality decreased after ELF4 knockdown (20.70% control vs. 17.49% si-scramble vs. 2.40% si-ELF4; p < 0.001). Knockdown of ELF4 induced DNA damage at the 4-cell stage. Interfering with ELF4 result

…
The embryonic developmental competency and blastocyst quality decreased after ELF4 knockdown (20.70% control vs. 17.49% si-scramble v …
Molecular and functional dissection of EARLY-FLOWERING 3 (ELF3) and ELF4 in Arabidopsis.
Zhao H, Xu D, Tian T, Kong F, Lin K, Gan S, Zhang H, Li G. Zhao H, et al. Plant Sci. 2021 Feb;303:110786. doi: 10.1016/j.plantsci.2020.110786. Epub 2020 Dec 3. Plant Sci. 2021. PMID: 33487361 Review.
The circadian clock is an endogenous timekeeper system that generates biological rhythms of approximately 24 h in most organisms. EARLY FLOWERING 3 (ELF3) and ELF4 were initially identified as negative regulators of flowering time in Arabidopsis thaliana. ...In this review …
The circadian clock is an endogenous timekeeper system that generates biological rhythms of approximately 24 h in most organisms. EARLY FLOW …
[ELF4 promotes proliferation and inhibits apoptosis of human insulinoma cells by activating Akt signaling].
Wei G, Wang L, Wan X, Tan Y. Wei G, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2021 Aug 31;41(9):1329-1333. doi: 10.12122/j.issn.1673-4254.2021.09.06. Nan Fang Yi Ke Da Xue Xue Bao. 2021. PMID: 34658346 Free PMC article. Chinese.
METHODS: A human insulinoma BON cell line with stable overexpression of ELF4 (BON-ELF4 cells) was constructed using a recombinant retrovirus vector and the expression of ELF4 protein was verified using Western blotting. ...RESULTS: BON-ELF4 cell line w …
METHODS: A human insulinoma BON cell line with stable overexpression of ELF4 (BON-ELF4 cells) was constructed using a recombin …
Elf4 regulates lysosomal biogenesis and the mTOR pathway to promote clearance of Staphylococcus aureus in macrophages.
Kang Y, Wu T, He Y, He Y, Zhao D. Kang Y, et al. FEBS Lett. 2021 Apr;595(7):881-891. doi: 10.1002/1873-3468.14037. Epub 2021 Mar 2. FEBS Lett. 2021. PMID: 33423322 Free article.
Our data show that Elf4 is induced by S. aureus in macrophages. Elevated expression of Elf4 results in decreased bacterial load and inflammatory responses during S. aureus infection in vivo and in vitro. Elf4-overexpressed macrophages have decreased mTOR acti …
Our data show that Elf4 is induced by S. aureus in macrophages. Elevated expression of Elf4 results in decreased bacterial loa …
262 results