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Circulating polymers in α1-antitrypsin deficiency.
Tan L, Dickens JA, Demeo DL, Miranda E, Perez J, Rashid ST, Day J, Ordoñez A, Marciniak SJ, Haq I, Barker AF, Campbell EJ, Eden E, McElvaney NG, Rennard SI, Sandhaus RA, Stocks JM, Stoller JK, Strange C, Turino G, Rouhani FN, Brantly M, Lomas DA. Tan L, et al. Eur Respir J. 2014 May;43(5):1501-4. doi: 10.1183/09031936.00111213. Epub 2014 Mar 6. Eur Respir J. 2014. PMID: 24603821 Free article. No abstract available.
Development, validation and use of ELISA for antibodies to human alpha-1 antitrypsin.
Ye GJ, Oshins RA, Rouhani FN, Brantly ML, Chulay JD. Ye GJ, et al. J Immunol Methods. 2013 Feb 28;388(1-2):18-24. doi: 10.1016/j.jim.2012.11.008. Epub 2012 Nov 27. J Immunol Methods. 2013. PMID: 23195820
Evaluation of human antibody responses to alpha-1 antitrypsin (AAT) in clinical trials and clinical practice has been limited by the lack of a validated assay. Here we describe the development and validation of an ELISA method for quantification of human and nonhuma …
Evaluation of human antibody responses to alpha-1 antitrypsin (AAT) in clinical trials and clinical practice has been limited by the lack of …
Secretion of alpha-1-proteinase inhibitor requires an almost full length molecule.
Brodbeck RM, Brown JL. Brodbeck RM, et al. J Biol Chem. 1992 Jan 5;267(1):294-7. J Biol Chem. 1992. PMID: 1730596 Free article.
These secretory variants contain frameshift mutations leading to products with normal amino acid sequences to the points of the mutations followed by short, aberrant C-terminal sequences and then premature termination (Nukiwa, T., Takahashi, H., Brantly, M., Courtney, M., …
These secretory variants contain frameshift mutations leading to products with normal amino acid sequences to the points of the mutations fo …
Cigarette smoke exposed airway epithelial cell-derived EVs promote pro-inflammatory macrophage activation in alpha-1 antitrypsin deficiency.
Khodayari N, Oshins R, Mehrad B, Lascano JE, Qiang X, West JR, Holliday LS, Lee J, Wiesemann G, Eydgahi S, Brantly M. Khodayari N, et al. Respir Res. 2022 Sep 6;23(1):232. doi: 10.1186/s12931-022-02161-z. Respir Res. 2022. PMID: 36068572 Free PMC article.
Macrophage endoplasmic reticulum stress was quantified and secreted cytokines were measured using qPCR and cytokine ELISAs. To determine whether there is "cross talk" between epithelial cells and macrophages, macrophages were exposed to extracellular vesicles released by a …
Macrophage endoplasmic reticulum stress was quantified and secreted cytokines were measured using qPCR and cytokine ELISAs. To determ …
Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant.
Mulgrew AT, Taggart CC, Lawless MW, Greene CM, Brantly ML, O'Neill SJ, McElvaney NG. Mulgrew AT, et al. Chest. 2004 May;125(5):1952-7. doi: 10.1378/chest.125.5.1952. Chest. 2004. PMID: 15136414
In addition, the Z protein formed in the lung polymerizes, and these polymers are detectable in lung epithelial lining fluid by enzyme-linked immunosorbent assay and Western blot analysis. Finally, we show that polymeric ZA1AT is a potent neutrophil ch …
In addition, the Z protein formed in the lung polymerizes, and these polymers are detectable in lung epithelial lining fluid by enzyme …
Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy.
Brantly ML, Chulay JD, Wang L, Mueller C, Humphries M, Spencer LT, Rouhani F, Conlon TJ, Calcedo R, Betts MR, Spencer C, Byrne BJ, Wilson JM, Flotte TR. Brantly ML, et al. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16363-8. doi: 10.1073/pnas.0904514106. Epub 2009 Aug 12. Proc Natl Acad Sci U S A. 2009. PMID: 19706466 Free PMC article. Clinical Trial.
M-specific AAT was expressed above background in all subjects in cohorts 2 and 3 and was sustained at levels 0.1% of normal for at least 1 year in the highest dosage level cohort, despite development of neutralizing antibody and IFN-gamma enzyme-linked immunospot re …
M-specific AAT was expressed above background in all subjects in cohorts 2 and 3 and was sustained at levels 0.1% of normal for at least 1 y …
Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing α1-antitrypsin: interim results.
Flotte TR, Trapnell BC, Humphries M, Carey B, Calcedo R, Rouhani F, Campbell-Thompson M, Yachnis AT, Sandhaus RA, McElvaney NG, Mueller C, Messina LM, Wilson JM, Brantly M, Knop DR, Ye GJ, Chulay JD. Flotte TR, et al. Hum Gene Ther. 2011 Oct;22(10):1239-47. doi: 10.1089/hum.2011.053. Epub 2011 Aug 24. Hum Gene Ther. 2011. PMID: 21609134 Free PMC article. Clinical Trial.
As expected, all subjects developed anti-AAV antibodies and interferon-gamma enzyme-linked immunospot responses to AAV peptides, and no subjects developed antibodies to AAT. ...
As expected, all subjects developed anti-AAV antibodies and interferon-gamma enzyme-linked immunospot responses to AAV peptide …
Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model.
Grimstein C, Choi YK, Wasserfall CH, Satoh M, Atkinson MA, Brantly ML, Campbell-Thompson M, Song S. Grimstein C, et al. J Transl Med. 2011 Feb 24;9:21. doi: 10.1186/1479-5876-9-21. J Transl Med. 2011. PMID: 21345239 Free PMC article.
Serum levels of B-cell activating factor of the TNF-alpha family (BAFF), antibodies against both bovine (bCII) and mouse collagen II (mCII) were tested by ELISA. RESULTS: Human AAT protein therapy as well as recombinant adeno-associated virus (rAAV8)-mediated hAAT gene the …
Serum levels of B-cell activating factor of the TNF-alpha family (BAFF), antibodies against both bovine (bCII) and mouse collagen II (mCII) …
Seasonal abundance, vector behavior, and malaria parasite transmission in Eritrea.
Shililu J, Ghebremeskel T, Seulu F, Mengistu S, Fekadu H, Zerom M, Asmelash GE, Sintasath D, Mbogo C, Githure J, Brantly E, Beier JC, Novak RJ. Shililu J, et al. J Am Mosq Control Assoc. 2004 Jun;20(2):155-64. J Am Mosq Control Assoc. 2004. PMID: 15264625
Of the total positive An. arabiensis (n = 64), 18.2% came from human-landing collections outdoors. Blood-meal analysis by enzyme-linked immunosorbent assay for An. arabiensis indicated that this species was partially zoophilic with a human to bovine ra …
Of the total positive An. arabiensis (n = 64), 18.2% came from human-landing collections outdoors. Blood-meal analysis by enzyme-l …