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2005 4
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112 results

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Page 1
EMP3 sustains oncogenic EGFR/CDK2 signaling by restricting receptor degradation in glioblastoma.
Martija AA, Krauß A, Bächle N, Doth L, Christians A, Krunic D, Schneider M, Helm D, Will R, Hartmann C, Herold-Mende C, von Deimling A, Pusch S. Martija AA, et al. Acta Neuropathol Commun. 2023 Nov 7;11(1):177. doi: 10.1186/s40478-023-01673-z. Acta Neuropathol Commun. 2023. PMID: 37936247 Free PMC article.
Epithelial membrane protein 3 (EMP3) is an N-glycosylated tetraspanin with a putative trafficking function. ...Here, we show that EMP3 promotes EGFR/CDK2 signaling by regulating the trafficking and enhancing the stability of EGFR. ...
Epithelial membrane protein 3 (EMP3) is an N-glycosylated tetraspanin with a putative trafficking function. ...Here, we show that …
The Multifunctional Role of EMP3 in the Regulation of Membrane Receptors Associated with IDH-Wild-Type Glioblastoma.
Martija AA, Pusch S. Martija AA, et al. Int J Mol Sci. 2021 May 17;22(10):5261. doi: 10.3390/ijms22105261. Int J Mol Sci. 2021. PMID: 34067658 Free PMC article. Review.
In this review, we summarize what is currently known about EMP3 biology. We discuss the regulatory effects that EMP3 exerts on a variety of oncogenic receptors and discuss how these mechanisms may relate to IDH-wt GBM. Lastly, we enumerate the open questions towards …
In this review, we summarize what is currently known about EMP3 biology. We discuss the regulatory effects that EMP3 exerts on …
EMP3 as a key downstream target of miR-663a regulation interferes with MAPK/ERK signaling pathway to inhibit gallbladder cancer progression.
Ma Q, Zhang Y, Liang H, Zhang F, Liu F, Chen S, Hu Y, Jiang L, Hao Y, Li M, Liu Y. Ma Q, et al. Cancer Lett. 2023 Oct 28;575:216398. doi: 10.1016/j.canlet.2023.216398. Epub 2023 Sep 18. Cancer Lett. 2023. PMID: 37730106
Conversely, the depletion of EMP3 promoted GBC cell growth and metastasis. In addition, we found that EMP3 was a target gene of miR-663a, and the downregulation of EMP3 in GBC was attributed to the overexpression of miR-663a. ...These data reveal the mechanis …
Conversely, the depletion of EMP3 promoted GBC cell growth and metastasis. In addition, we found that EMP3 was a target gene o …
EMP3 as a prognostic biomarker correlates with EMT in GBM.
Li L, Xia S, Zhao Z, Deng L, Wang H, Yang D, Hu Y, Ji J, Huang D, Xin T. Li L, et al. BMC Cancer. 2024 Jan 17;24(1):89. doi: 10.1186/s12885-023-11796-0. BMC Cancer. 2024. PMID: 38229014 Free PMC article.
EMP3 is enriched in high-grade gliomas and isocitrate dehydrogenase (IDH) wild-type gliomas.EMP3 can be used as a specific biomarker for diagnosing glioma patients. ...CONCLUSION: EMP3 promotes the proliferation and migration of GBM cells, and the mechanism m …
EMP3 is enriched in high-grade gliomas and isocitrate dehydrogenase (IDH) wild-type gliomas.EMP3 can be used as a specific bio …
EMP3 as a candidate tumor suppressor gene for solid tumors.
Fumoto S, Tanimoto K, Hiyama E, Noguchi T, Nishiyama M, Hiyama K. Fumoto S, et al. Expert Opin Ther Targets. 2009 Jul;13(7):811-22. doi: 10.1517/14728220902988549. Expert Opin Ther Targets. 2009. PMID: 19466912 Review.
OBJECTIVE: To clarify the discrepancies in the biological behavior of EMP3 among the different organ-derived malignancies or histologies and validate the potential of EMP3 as a tumor suppressor for solid tumors. METHODS: Literature dealing with EMP3 in the Pu …
OBJECTIVE: To clarify the discrepancies in the biological behavior of EMP3 among the different organ-derived malignancies or histolog …
EMP3 negatively modulates breast cancer cell DNA replication, DNA damage repair, and stem-like properties.
Zhou K, Sun Y, Dong D, Zhao C, Wang W. Zhou K, et al. Cell Death Dis. 2021 Sep 12;12(9):844. doi: 10.1038/s41419-021-04140-6. Cell Death Dis. 2021. PMID: 34511602 Free PMC article.
EMP3 negatively modulates BRCA1 and RAD51 expression, indicating EMP3 suppresses homologous recombination repair of DNA double-strand breaks. ...EMP3 downregulates YTHDC1, a RNA-binding protein involved in m6a modification, which at least in part mediates the …
EMP3 negatively modulates BRCA1 and RAD51 expression, indicating EMP3 suppresses homologous recombination repair of DNA double …
EMP1, EMP 2, and EMP3 as novel therapeutic targets in human cancer.
Wang YW, Cheng HL, Ding YR, Chou LH, Chow NH. Wang YW, et al. Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):199-211. doi: 10.1016/j.bbcan.2017.04.004. Epub 2017 Apr 10. Biochim Biophys Acta Rev Cancer. 2017. PMID: 28408326 Review.
The epithelial membrane protein genes 1, 2, and 3 (EMP1, EMP2, and EMP3) belong to the peripheral myelin protein 22-kDa (PMP22) gene family, which consists of at least seven members: PMP22, EMP1, EMP2, EMP3, PERP, brain cell membrane protein 1, and MP20. ...Co-expre …
The epithelial membrane protein genes 1, 2, and 3 (EMP1, EMP2, and EMP3) belong to the peripheral myelin protein 22-kDa (PMP22) gene …
EMP3 mediates glioblastoma-associated macrophage infiltration to drive T cell exclusion.
Chen Q, Jin J, Huang X, Wu F, Huang H, Zhan R. Chen Q, et al. J Exp Clin Cancer Res. 2021 May 8;40(1):160. doi: 10.1186/s13046-021-01954-2. J Exp Clin Cancer Res. 2021. PMID: 33964937 Free PMC article.
The role of EMP3 in GBM was validated through in vivo and in vitro experiments. Human GBM specimens were collected and evaluated using immunofluorescence analysis. RESULTS: EMP3 was associated with immunosuppression in GBM. Elevated EMP3 in GBM areas was acco …
The role of EMP3 in GBM was validated through in vivo and in vitro experiments. Human GBM specimens were collected and evaluated usin …
Identification of candidate biomarker EMP3 and its prognostic potential in clear cell renal cell carcinoma.
Lv Q, Xiao W, Xiong Z, Shi J, Miao D, Meng X, Yuan H, Yang H, Zhang X. Lv Q, et al. Front Biosci (Landmark Ed). 2021 Nov 30;26(11):1176-1190. doi: 10.52586/5018. Front Biosci (Landmark Ed). 2021. PMID: 34856762 Free article.
Western blotting was used to explore the potential mechanism of EMP3 induced ccRCC deterioration. Finally, the TIMER2.0 database was used to explore the effect of EMP3 on tumor immune infiltration and its relationship with multiple immune checkpoints. ...Targeted …
Western blotting was used to explore the potential mechanism of EMP3 induced ccRCC deterioration. Finally, the TIMER2.0 database was …
Expression of EMP1, EMP2, and EMP3 in breast phyllodes tumors.
Cha YJ, Koo JS. Cha YJ, et al. PLoS One. 2020 Aug 28;15(8):e0238466. doi: 10.1371/journal.pone.0238466. eCollection 2020. PLoS One. 2020. PMID: 32857809 Free PMC article.
Expression of EMP1 and EMP3 correlated positively with stromal cellularity and cellular atypia (P < 0.001). ...Thus, stromal EMP3 expression may serve as an independent prognostic factor in PT....

Expression of EMP1 and EMP3 correlated positively with stromal cellularity and cellular atypia (P < 0.001). ...Thus, stromal EM

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112 results