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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1850 1
1896 1
1946 2
1947 1
1948 1
1950 2
1951 2
1952 4
1953 1
1954 2
1955 2
1958 1
1961 3
1962 2
1963 2
1965 1
1967 1
1968 1
1969 2
1970 1
1971 8
1972 2
1973 4
1974 1
1976 2
1977 3
1978 4
1979 4
1980 14
1981 6
1982 2
1983 2
1984 2
1985 2
1986 4
1987 2
1988 3
1989 4
1990 4
1991 2
1992 2
1993 4
1994 14
1995 32
1996 75
1997 122
1998 176
1999 270
2000 321
2001 381
2002 448
2003 560
2004 636
2005 734
2006 799
2007 786
2008 788
2009 799
2010 907
2011 958
2012 1031
2013 1061
2014 1038
2015 1006
2016 917
2017 908
2018 938
2019 918
2020 879
2021 878
2022 774
2023 676
2024 288

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17,844 results

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The following term was not found in PubMed: Bijbel
Page 1
Red Blood Cell and Endothelial eNOS Independently Regulate Circulating Nitric Oxide Metabolites and Blood Pressure.
Leo F, Suvorava T, Heuser SK, Li J, LoBue A, Barbarino F, Piragine E, Schneckmann R, Hutzler B, Good ME, Fernandez BO, Vornholz L, Rogers S, Doctor A, Grandoch M, Stegbauer J, Weitzberg E, Feelisch M, Lundberg JO, Isakson BE, Kelm M, Cortese-Krott MM. Leo F, et al. Circulation. 2021 Sep 14;144(11):870-889. doi: 10.1161/CIRCULATIONAHA.120.049606. Epub 2021 Jul 7. Circulation. 2021. PMID: 34229449 Free PMC article.
We created 2 founder lines carrying a floxed eNOS (eNOS(flox/flox)) for Cre-inducible knockout (KO), and gene construct with an inactivated floxed/inverted exon (eNOS(inv/inv)) for a Cre-inducible knock-in (KI), which respectively allow targeted deletion or r …
We created 2 founder lines carrying a floxed eNOS (eNOS(flox/flox)) for Cre-inducible knockout (KO), and gene construct with a …
Roles of eNOS in atherosclerosis treatment.
Hong FF, Liang XY, Liu W, Lv S, He SJ, Kuang HB, Yang SL. Hong FF, et al. Inflamm Res. 2019 Jun;68(6):429-441. doi: 10.1007/s00011-019-01229-9. Epub 2019 Apr 1. Inflamm Res. 2019. PMID: 30937466 Review.
Finally, literature data were organized to discuss these main points logically. We found that both aberrant expression and dysfunction of eNOS are closely related to AS development, and some new treatment strategies aimed at eNOS have been proposed, including upregu …
Finally, literature data were organized to discuss these main points logically. We found that both aberrant expression and dysfunction of …
Red blood cell eNOS is cardioprotective in acute myocardial infarction.
Cortese-Krott MM, Suvorava T, Leo F, Heuser SK, LoBue A, Li J, Becher S, Schneckmann R, Srivrastava T, Erkens R, Wolff G, Schmitt JP, Grandoch M, Lundberg JO, Pernow J, Isakson BE, Weitzberg E, Kelm M. Cortese-Krott MM, et al. Redox Biol. 2022 Aug;54:102370. doi: 10.1016/j.redox.2022.102370. Epub 2022 Jun 18. Redox Biol. 2022. PMID: 35759945 Free PMC article.
To specifically distinguish the role of RBC eNOS from the endothelial cell (EC) eNOS, we generated RBC- and EC-specific knock-out (KO) and knock-in (KI) mice by Cre-induced inactivation or reactivation of eNOS. ...In contrast, EC eNOS KO and EC eNOS …
To specifically distinguish the role of RBC eNOS from the endothelial cell (EC) eNOS, we generated RBC- and EC-specific knock- …
S1P and eNOS regulation.
Igarashi J, Michel T. Igarashi J, et al. Biochim Biophys Acta. 2008 Sep;1781(9):489-95. doi: 10.1016/j.bbalip.2008.06.008. Epub 2008 Jun 27. Biochim Biophys Acta. 2008. PMID: 18638569 Review.
Sphingosine 1-phosphate (S1P) has recently been identified as an important activator of eNOS. This review summarizes the roles of sphingosine 1-phosphate and S1P receptors in eNOS activation, and analyzes the eNOS regulatory processes evoked by S1P. The impli …
Sphingosine 1-phosphate (S1P) has recently been identified as an important activator of eNOS. This review summarizes the roles of sph …
Regulation of eNOS in caveolae.
Mineo C, Shaul PW. Mineo C, et al. Adv Exp Med Biol. 2012;729:51-62. doi: 10.1007/978-1-4614-1222-9_4. Adv Exp Med Biol. 2012. PMID: 22411313 Review.
In particular, high density lipoprotein cholesterol (HDL) maintains the lipid environment in caveolae, thereby promoting the retention and function of eNOS in the domain and it also causes direct activation of eNOS via scavenger receptor class B, Type I (SR-BI)-indu …
In particular, high density lipoprotein cholesterol (HDL) maintains the lipid environment in caveolae, thereby promoting the retention and f …
Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets.
Janaszak-Jasiecka A, Płoska A, Wierońska JM, Dobrucki LW, Kalinowski L. Janaszak-Jasiecka A, et al. Cell Mol Biol Lett. 2023 Mar 9;28(1):21. doi: 10.1186/s11658-023-00423-2. Cell Mol Biol Lett. 2023. PMID: 36890458 Free PMC article.
Here, we discuss the main mechanisms of eNOS uncoupling, including oxidative depletion of the critical eNOS cofactor BH(4), deficiency of eNOS substrate L-Arg, or accumulation of its analog asymmetrical dimethylarginine (ADMA), and eNOS S-glutathionyla …
Here, we discuss the main mechanisms of eNOS uncoupling, including oxidative depletion of the critical eNOS cofactor BH(4), de …
Effects of resveratrol on eNOS in the endothelium and the perivascular adipose tissue.
Xia N, Förstermann U, Li H. Xia N, et al. Ann N Y Acad Sci. 2017 Sep;1403(1):132-141. doi: 10.1111/nyas.13397. Epub 2017 Jul 3. Ann N Y Acad Sci. 2017. PMID: 28672425 Review.
Under physiological conditions, nitric oxide (NO) is produced in the vasculature mainly by the endothelial NO synthase (eNOS). Experiments using gene-disrupted mice have demonstrated that eNOS has antihypertensive, antithrombotic, and antiatherosclerotic effects. .. …
Under physiological conditions, nitric oxide (NO) is produced in the vasculature mainly by the endothelial NO synthase (eNOS). Experi …
eNOS phosphorylation in health and disease.
Kolluru GK, Siamwala JH, Chatterjee S. Kolluru GK, et al. Biochimie. 2010 Sep;92(9):1186-98. doi: 10.1016/j.biochi.2010.03.020. Epub 2010 Apr 2. Biochimie. 2010. PMID: 20363286 Review.
Endothelium regulates these cellular processes by activating endothelial nitric oxide synthase (eNOS) responsible for nitric oxide (NO) production. eNOS is constitutively expressed in ECs in response to humoral, mechanical or pharmacological stimulus. eNOS ac …
Endothelium regulates these cellular processes by activating endothelial nitric oxide synthase (eNOS) responsible for nitric oxide (N …
Exercise-Induced Cardioprotection via eNOS: A Putative Role of Red Blood Cell Signaling.
Suvorava T, Cortese-Krott MM. Suvorava T, et al. Curr Med Chem. 2018;25(34):4457-4474. doi: 10.2174/0929867325666180307112557. Curr Med Chem. 2018. PMID: 29521199 Review.
Our group and others demonstrated that RBCs contain a functional eNOS, which contributes to systemic nitrite homeostasis and to cardioprotection; moreover, expression and activity of red cell eNOS are decreased in CAD patients and significantly correlated with flow- …
Our group and others demonstrated that RBCs contain a functional eNOS, which contributes to systemic nitrite homeostasis and to cardi …
Hepatocyte-specific eNOS deletion impairs exercise-induced adaptations in hepatic mitochondrial function and autophagy.
Cunningham RP, Moore MP, Dashek RJ, Meers GM, Jepkemoi V, Takahashi T, Vieira-Potter VJ, Kanaley JA, Booth FW, Rector RS. Cunningham RP, et al. Obesity (Silver Spring). 2022 May;30(5):1066-1078. doi: 10.1002/oby.23414. Epub 2022 Mar 31. Obesity (Silver Spring). 2022. PMID: 35357089 Free PMC article.
METHODS: Here, male and female hepatocyte-specific eNOS knockout (eNOS(hep-/-) ) and intact hepatic eNOS (eNOS(fl/fl) ) mice performed voluntary wheel-running exercise (EX) or remained in sedentary cage conditions for 10 weeks. RESULTS: EX resolved the …
METHODS: Here, male and female hepatocyte-specific eNOS knockout (eNOS(hep-/-) ) and intact hepatic eNOS (eNOS(f …
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