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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
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1996 1
2001 2
2002 3
2003 3
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2005 3
2006 5
2007 10
2008 14
2009 15
2010 12
2011 18
2012 23
2013 23
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424 results

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Page 1
Disruption of Ephx2 in cardiomyocytes but not endothelial cells improves functional recovery after ischemia-reperfusion in isolated mouse hearts.
Edin ML, Gruzdev A, Bradbury JA, Graves JP, Lih FB, DeGraff LM, Fleming I, Zeldin DC. Edin ML, et al. J Biol Chem. 2023 Apr;299(4):103049. doi: 10.1016/j.jbc.2023.103049. Epub 2023 Feb 22. J Biol Chem. 2023. PMID: 36822325 Free PMC article.
To determine specific roles of EPHX2 in cardiac cell types, we generated mice with cell-specific disruption of Ephx2 in endothelial cells (Ephx2(fx/fx)/Tek-cre) or cardiomyocytes (Ephx2(fx/fx)/Myh6-cre) to compare to global Ephx2-deficient mice …
To determine specific roles of EPHX2 in cardiac cell types, we generated mice with cell-specific disruption of Ephx2 in endoth …
Systematic druggable genome-wide Mendelian randomisation identifies therapeutic targets for Alzheimer's disease.
Su WM, Gu XJ, Dou M, Duan QQ, Jiang Z, Yin KF, Cai WC, Cao B, Wang Y, Chen YP. Su WM, et al. J Neurol Neurosurg Psychiatry. 2023 Nov;94(11):954-961. doi: 10.1136/jnnp-2023-331142. Epub 2023 Jun 22. J Neurol Neurosurg Psychiatry. 2023. PMID: 37349091 Free PMC article.
Among them, three prior druggable genes (epoxide hydrolase 2 (EPHX2), SERPINB1 and SIGLEC11) reached significant levels in both blood and brain tissues. EPHX2 may mediate the pathogenesis of AD by affecting the entire hippocampal volume. ...
Among them, three prior druggable genes (epoxide hydrolase 2 (EPHX2), SERPINB1 and SIGLEC11) reached significant levels in both blood …
Clinical significance of EPHX2 deregulation in prostate cancer.
Liu MS, Zhao H, Xu CX, Xie PB, Wang W, Yang YY, Lee WH, Jin Y, Zhou HQ. Liu MS, et al. Asian J Androl. 2021 Jan-Feb;23(1):109-115. doi: 10.4103/aja.aja_34_20. Asian J Androl. 2021. PMID: 32687069 Free PMC article.
Furthermore, EPHX2 mRNA expression was significantly decreased in metastatic and recurrent PCa compared with localized and primary PCa, respectively. In addition, EPHX2 protein expression correlated negatively with Ki67 expression. ...
Furthermore, EPHX2 mRNA expression was significantly decreased in metastatic and recurrent PCa compared with localized and primary PC …
Identification and validation of EPHX2 as a prognostic biomarker in hepatocellular carcinoma.
Zhan K, Bai Y, Liao S, Chen H, Kuang L, Luo Q, Lv L, Qiu L, Mei Z. Zhan K, et al. Mol Med Rep. 2021 Sep;24(3):650. doi: 10.3892/mmr.2021.12289. Epub 2021 Jul 19. Mol Med Rep. 2021. PMID: 34278494 Free PMC article.
Additionally, Kaplan-Meier survival curves indicated that patients with higher EPHX2 expression exhibited better prognosis, and clinicopathological analysis also revealed elevated EPHX2 levels in patients with early-stage HCC. ...Finally, the prognostic value of …
Additionally, Kaplan-Meier survival curves indicated that patients with higher EPHX2 expression exhibited better prognosis, and clini …
Ephx2-gene deletion affects acetylcholine-induced relaxation in angiotensin-II infused mice: role of nitric oxide and CYP-epoxygenases.
Hanif A, Edin ML, Zeldin DC, Nayeem MA. Hanif A, et al. Mol Cell Biochem. 2020 Feb;465(1-2):37-51. doi: 10.1007/s11010-019-03665-x. Epub 2019 Dec 4. Mol Cell Biochem. 2020. PMID: 31797255 Free PMC article.
However, Ach-induced relaxation was inhibited with L-NAME (Ephx2(-/-): 23.74 3.76% and C57Bl/6: 11.61 2.82%), MS-PPOH (Ephx2(-/-): 48.16 6.53% and C57Bl/6: 52.27 7.47%), and 14,15-EEZE (Ephx2(-/-): 44.29 8.33% and C57Bl/6: 39.27 7.47%) vs. non-treated (P < …
However, Ach-induced relaxation was inhibited with L-NAME (Ephx2(-/-): 23.74 3.76% and C57Bl/6: 11.61 2.82%), MS-PPOH (Ephx2(- …
EPHX2 Inhibits Colon Cancer Progression by Promoting Fatty Acid Degradation.
Zhou Y, Li X, Guan A, Zhou H, Zhu Y, Wang R, Li R. Zhou Y, et al. Front Oncol. 2022 Mar 30;12:870721. doi: 10.3389/fonc.2022.870721. eCollection 2022. Front Oncol. 2022. PMID: 35433439 Free PMC article.
In this study, through multi-data combined with bioinformatic analysis and basic experiments, we introduced a tumor suppressor gene, EPHX2, which is rarely reported in CRC, and confirmed that its inhibitory effect on CRC is related to fatty acid degradation....
In this study, through multi-data combined with bioinformatic analysis and basic experiments, we introduced a tumor suppressor gene, EPHX …
Soluble epoxide hydrolase (Ephx2) silencing attenuates the hydrogen peroxide-induced oxidative damage in IEC-6 cells.
Li X, Wu X. Li X, et al. Arch Med Sci. 2019 Aug 22;17(4):1075-1086. doi: 10.5114/aoms.2019.87137. eCollection 2021. Arch Med Sci. 2019. PMID: 34336035 Free PMC article.
In addition, the anti-apoptotic effect of si-Ephx2 was enhanced in the presence of AUDA-pharmacological Ephx2 inhibitor. CONCLUSIONS: Ephx2 silencing inhibited H(2)O(2)-induced oxidative damage. The PI3K/Akt/GSK3beta pathway was related to the effect of si- …
In addition, the anti-apoptotic effect of si-Ephx2 was enhanced in the presence of AUDA-pharmacological Ephx2 inhibitor. CONCL …
Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis.
Wingo AP, Liu Y, Gerasimov ES, Gockley J, Logsdon BA, Duong DM, Dammer EB, Robins C, Beach TG, Reiman EM, Epstein MP, De Jager PL, Lah JJ, Bennett DA, Seyfried NT, Levey AI, Wingo TS. Wingo AP, et al. Nat Genet. 2021 Feb;53(2):143-146. doi: 10.1038/s41588-020-00773-z. Epub 2021 Jan 28. Nat Genet. 2021. PMID: 33510477 Free PMC article.
Enhancement of the liver's neuroprotective role ameliorates traumatic brain injury pathology.
Dai Y, Dong J, Wu Y, Zhu M, Xiong W, Li H, Zhao Y, Hammock BD, Zhu X. Dai Y, et al. Proc Natl Acad Sci U S A. 2023 Jun 27;120(26):e2301360120. doi: 10.1073/pnas.2301360120. Epub 2023 Jun 20. Proc Natl Acad Sci U S A. 2023. PMID: 37339206 Free PMC article.
Using two mouse models of TBI, we found that the enzymatic activity of hepatic soluble epoxide hydrolase (sEH) was rapidly decreased and then returned to normal levels following TBI, whereas such changes were not observed in the kidney, heart, spleen, or lung. Interestingly, gene …
Using two mouse models of TBI, we found that the enzymatic activity of hepatic soluble epoxide hydrolase (sEH) was rapidly decreased and the …
424 results