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Towards Gram-negative antivirulence drugs: new inhibitors of HldE kinase.
Desroy N, Moreau F, Briet S, Le Fralliec G, Floquet S, Durant L, Vongsouthi V, Gerusz V, Denis A, Escaich S. Desroy N, et al. Among authors: escaich s. Bioorg Med Chem. 2009 Feb 1;17(3):1276-89. doi: 10.1016/j.bmc.2008.12.021. Epub 2008 Dec 24. Bioorg Med Chem. 2009. PMID: 19124251
From triclosan toward the clinic: discovery of nonbiocidal, potent FabI inhibitors for the treatment of resistant bacteria.
Gerusz V, Denis A, Faivre F, Bonvin Y, Oxoby M, Briet S, LeFralliec G, Oliveira C, Desroy N, Raymond C, Peltier L, Moreau F, Escaich S, Vongsouthi V, Floquet S, Drocourt E, Walton A, Prouvensier L, Saccomani M, Durant L, Genevard JM, Sam-Sambo V, Soulama-Mouze C. Gerusz V, et al. Among authors: escaich s. J Med Chem. 2012 Nov 26;55(22):9914-28. doi: 10.1021/jm301113w. Epub 2012 Oct 23. J Med Chem. 2012. PMID: 23092194
Novel HldE-K inhibitors leading to attenuated Gram negative bacterial virulence.
Desroy N, Denis A, Oliveira C, Atamanyuk D, Briet S, Faivre F, LeFralliec G, Bonvin Y, Oxoby M, Escaich S, Floquet S, Drocourt E, Vongsouthi V, Durant L, Moreau F, Verhey TB, Lee TW, Junop MS, Gerusz V. Desroy N, et al. Among authors: escaich s. J Med Chem. 2013 Feb 28;56(4):1418-30. doi: 10.1021/jm301499r. Epub 2013 Feb 14. J Med Chem. 2013. PMID: 23409840
The MUT056399 inhibitor of FabI is a new antistaphylococcal compound.
Escaich S, Prouvensier L, Saccomani M, Durant L, Oxoby M, Gerusz V, Moreau F, Vongsouthi V, Maher K, Morrissey I, Soulama-Mouze C. Escaich S, et al. Antimicrob Agents Chemother. 2011 Oct;55(10):4692-7. doi: 10.1128/AAC.01248-10. Epub 2011 Aug 8. Antimicrob Agents Chemother. 2011. PMID: 21825292 Free PMC article.
31 results