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NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol.
Benjannet S, Rhainds D, Essalmani R, Mayne J, Wickham L, Jin W, Asselin MC, Hamelin J, Varret M, Allard D, Trillard M, Abifadel M, Tebon A, Attie AD, Rader DJ, Boileau C, Brissette L, Chrétien M, Prat A, Seidah NG. Benjannet S, et al. Among authors: essalmani r. J Biol Chem. 2004 Nov 19;279(47):48865-75. doi: 10.1074/jbc.M409699200. Epub 2004 Sep 9. J Biol Chem. 2004. PMID: 15358785 Free article.
The activation and physiological functions of the proprotein convertases.
Seidah NG, Mayer G, Zaid A, Rousselet E, Nassoury N, Poirier S, Essalmani R, Prat A. Seidah NG, et al. Among authors: essalmani r. Int J Biochem Cell Biol. 2008;40(6-7):1111-25. doi: 10.1016/j.biocel.2008.01.030. Epub 2008 Feb 8. Int J Biochem Cell Biol. 2008. PMID: 18343183 Review.
VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5.
Szumska D, Pieles G, Essalmani R, Bilski M, Mesnard D, Kaur K, Franklyn A, El Omari K, Jefferis J, Bentham J, Taylor JM, Schneider JE, Arnold SJ, Johnson P, Tymowska-Lalanne Z, Stammers D, Clarke K, Neubauer S, Morris A, Brown SD, Shaw-Smith C, Cama A, Capra V, Ragoussis J, Constam D, Seidah NG, Prat A, Bhattacharya S. Szumska D, et al. Among authors: essalmani r. Genes Dev. 2008 Jun 1;22(11):1465-77. doi: 10.1101/gad.479408. Genes Dev. 2008. PMID: 18519639 Free PMC article.
In vivo evidence that furin from hepatocytes inactivates PCSK9.
Essalmani R, Susan-Resiga D, Chamberland A, Abifadel M, Creemers JW, Boileau C, Seidah NG, Prat A. Essalmani R, et al. J Biol Chem. 2011 Feb 11;286(6):4257-63. doi: 10.1074/jbc.M110.192104. Epub 2010 Dec 8. J Biol Chem. 2011. PMID: 21147780 Free PMC article.
51 results