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What does procollagen C-endopeptidase enhancer protein 2 have to do with HDL-cholesteryl ester uptake? Or how I learned to stop worrying and love reverse cholesterol transport?
Sorci-Thomas MG, Pollard RD, Thomas MJ. Sorci-Thomas MG, et al. Curr Opin Lipidol. 2015 Oct;26(5):420-5. doi: 10.1097/MOL.0000000000000211. Curr Opin Lipidol. 2015. PMID: 26218419 Free PMC article. Review.
Equally important is the second half of the RCT pathway in which the liver scavenger receptor class B1 selectively removes HDL cholesteryl esters for excretion. The combined action of the two enzyme systems is reflected in the overall steady-state concentration of plasma H …
Equally important is the second half of the RCT pathway in which the liver scavenger receptor class B1 selectively removes HDL cholesteryl …
The reaction mechanism of the Ideonella sakaiensis PETase enzyme.
Burgin T, Pollard BC, Knott BC, Mayes HB, Crowley MF, McGeehan JE, Beckham GT, Woodcock HL. Burgin T, et al. Commun Chem. 2024 Mar 27;7(1):65. doi: 10.1038/s42004-024-01154-x. Commun Chem. 2024. PMID: 38538850 Free PMC article.
We predict that deacylation is likely rate-limiting, and the reaction coordinates for both steps include elements describing nucleophilic attack, ester bond cleavage, and the "moving-histidine" mechanism. We find that the flexibility of Trp185 promotes the reaction, provid …
We predict that deacylation is likely rate-limiting, and the reaction coordinates for both steps include elements describing nucleophilic at …
Biochemical diagnosis of cystic fibrosis.
Carey WF, Pollard AC. Carey WF, et al. Med J Aust. 1983 Nov 26;2(11):528-9. doi: 10.5694/j.1326-5377.1983.tb122632.x. Med J Aust. 1983. PMID: 6633370 No abstract available.
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
Carroll FI, Runyon SP, Abraham P, Navarro H, Kuhar MJ, Pollard GT, Howard JL. Carroll FI, et al. J Med Chem. 2004 Dec 2;47(25):6401-9. doi: 10.1021/jm0401311. J Med Chem. 2004. PMID: 15566309
The monoamine transporter binding properties, gross behavior, and locomotor activity effects in mice and drug discrimination results in cocaine-trained rats of the 2 beta,3beta-, 2 beta,3 alpha-, 2 alpha,3beta-, and 2 alpha,3 alpha-isomers of several 3-(4-substituted-phenyl)tropa …
The monoamine transporter binding properties, gross behavior, and locomotor activity effects in mice and drug discrimination results in coca …
Procollagen C-endopeptidase Enhancer Protein 2 (PCPE2) Reduces Atherosclerosis in Mice by Enhancing Scavenger Receptor Class B1 (SR-BI)-mediated High-density Lipoprotein (HDL)-Cholesteryl Ester Uptake.
Pollard RD, Blesso CN, Zabalawi M, Fulp B, Gerelus M, Zhu X, Lyons EW, Nuradin N, Francone OL, Li XA, Sahoo D, Thomas MJ, Sorci-Thomas MG. Pollard RD, et al. J Biol Chem. 2015 Jun 19;290(25):15496-15511. doi: 10.1074/jbc.M115.646240. Epub 2015 May 6. J Biol Chem. 2015. PMID: 25947382 Free PMC article.
PCPE2 was shown to enhance SR-BI function by increasing the rate of HDL-associated cholesteryl ester uptake, possibly by optimizing SR-BI localization and/or conformation. ...
PCPE2 was shown to enhance SR-BI function by increasing the rate of HDL-associated cholesteryl ester uptake, possibly by optimizing S …
High-Density Lipoprotein Biogenesis: Defining the Domains Involved in Human Apolipoprotein A-I Lipidation.
Pollard RD, Fulp B, Sorci-Thomas MG, Thomas MJ. Pollard RD, et al. Biochemistry. 2016 Sep 6;55(35):4971-81. doi: 10.1021/acs.biochem.6b00347. Epub 2016 Aug 23. Biochemistry. 2016. PMID: 27501467 Free PMC article.
The first step in removing cholesterol from a cell is the ATP-binding cassette transporter 1 (ABCA1)-driven transfer of cholesterol to lipid-free or lipid-poor apolipoprotein A-I (apoA-I), which yields cholesterol-rich nascent high-density lipoprotein (nHDL) that then matures in …
The first step in removing cholesterol from a cell is the ATP-binding cassette transporter 1 (ABCA1)-driven transfer of cholesterol to lipid …
Protein kinase C mediated anti-proliferative glucocorticoid-sphinganine synergism in cultured Pollard III prostate tumor cells.
Sosnowski J, Stetter-Neel C, Cole D, Durham JP, Mawhinney MG. Sosnowski J, et al. J Urol. 1997 Jul;158(1):269-74. doi: 10.1097/00005392-199707000-00084. J Urol. 1997. PMID: 9186373
MATERIALS AND METHODS: Studies were performed in cell culture using the Pollard (PA) III androgen-insensitive spontaneous rat prostate tumor cells, and the human prostate tumor lines, PC-3 and LnCaP. ...TA produced no discernable stimulation of endogenous free sphingosine …
MATERIALS AND METHODS: Studies were performed in cell culture using the Pollard (PA) III androgen-insensitive spontaneous rat prostat …
A receptor-modifying deamidase in complex with a signaling phosphatase reveals reciprocal regulation.
Chao X, Muff TJ, Park SY, Zhang S, Pollard AM, Ordal GW, Bilwes AM, Crane BR. Chao X, et al. Cell. 2006 Feb 10;124(3):561-71. doi: 10.1016/j.cell.2005.11.046. Cell. 2006. PMID: 16469702 Free article.
CheD not only deamidates receptor glutamine residues contained within a conserved structural motif but also hydrolyzes glutamyl-methyl-esters at select regulatory positions. Substituting Gln into the receptor motif of CheC turns the inhibitor into a CheD substrate. ...
CheD not only deamidates receptor glutamine residues contained within a conserved structural motif but also hydrolyzes glutamyl-methyl-es …
Quantitative analysis of glycerol in dicarboxylic acid-rich cutins provides insights into Arabidopsis cutin structure.
Yang W, Pollard M, Li-Beisson Y, Ohlrogge J. Yang W, et al. Phytochemistry. 2016 Oct;130:159-69. doi: 10.1016/j.phytochem.2016.03.017. Epub 2016 May 19. Phytochemistry. 2016. PMID: 27211345 Free article.
Previous studies using partial hydrolysis of cuticle-enriched preparations established the presence of oligomers with glycerol-aliphatic ester links. Furthermore, glycerol-3-phosphate 2-O-acyltransferases (sn-2-GPATs) are essential for cutin biosynthesis. ...
Previous studies using partial hydrolysis of cuticle-enriched preparations established the presence of oligomers with glycerol-aliphatic …
Widespread exploitation of the honeybee by early Neolithic farmers.
Roffet-Salque M, Regert M, Evershed RP, Outram AK, Cramp LJ, Decavallas O, Dunne J, Gerbault P, Mileto S, Mirabaud S, Pääkkönen M, Smyth J, Šoberl L, Whelton HL, Alday-Ruiz A, Asplund H, Bartkowiak M, Bayer-Niemeier E, Belhouchet L, Bernardini F, Budja M, Cooney G, Cubas M, Danaher EM, Diniz M, Domboróczki L, Fabbri C, González-Urquijo JE, Guilaine J, Hachi S, Hartwell BN, Hofmann D, Hohle I, Ibáñez JJ, Karul N, Kherbouche F, Kiely J, Kotsakis K, Lueth F, Mallory JP, Manen C, Marciniak A, Maurice-Chabard B, Mc Gonigle MA, Mulazzani S, Özdoğan M, Perić OS, Perić SR, Petrasch J, Pétrequin AM, Pétrequin P, Poensgen U, Pollard CJ, Poplin F, Radi G, Stadler P, Stäuble H, Tasić N, Urem-Kotsou D, Vuković JB, Walsh F, Whittle A, Wolfram S, Zapata-Peña L, Zoughlami J. Roffet-Salque M, et al. Nature. 2015 Nov 12;527(7577):226-30. doi: 10.1038/nature15757. Nature. 2015. PMID: 26560301 Free article.
One of the major products of A. mellifera is beeswax, which is composed of a complex suite of lipids including n-alkanes, n-alkanoic acids and fatty acyl wax esters. The composition is highly constant as it is determined genetically through the insect's biochemistry. ...
One of the major products of A. mellifera is beeswax, which is composed of a complex suite of lipids including n-alkanes, n-alkanoic acids a …
34 results