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Year Number of Results
1993 2
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1997 13
1998 11
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2001 11
2002 15
2003 10
2004 13
2005 14
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2007 18
2008 21
2009 21
2010 30
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581 results

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Page 1
New 'Antigens' in Membranous Nephropathy.
Sethi S. Sethi S. J Am Soc Nephrol. 2021 Feb;32(2):268-278. doi: 10.1681/ASN.2020071082. Epub 2020 Dec 30. J Am Soc Nephrol. 2021. PMID: 33380523 Free PMC article. Review.
This approach led to the identification of four novel types of MN: exotosin 1 (EXT1)- and exotosin 2 (EXT2)-associated MN, NELL1-associated MN, Sema3B-associated MN, and PCDH7-associated MN. ...
This approach led to the identification of four novel types of MN: exotosin 1 (EXT1)- and exotosin 2 (EXT2)-associated MN, NELL1-asso …
Mechanisms of Primary Membranous Nephropathy.
Gu Y, Xu H, Tang D. Gu Y, et al. Biomolecules. 2021 Mar 30;11(4):513. doi: 10.3390/biom11040513. Biomolecules. 2021. PMID: 33808418 Free PMC article. Review.
Additionally, evidence is emerging that NELL-1 is associated with 5-10% of PMN cases that are PLA2R- and THSD7A-negative, which moves us one step closer to mapping out the full spectrum of PMN antigens. Recent developments suggest exostosin 1 (EXT1), EXT2, NELL-1, and cont …
Additionally, evidence is emerging that NELL-1 is associated with 5-10% of PMN cases that are PLA2R- and THSD7A-negative, which moves us one …
Membranous Nephropathy: Core Curriculum 2021.
Alsharhan L, Beck LH Jr. Alsharhan L, et al. Am J Kidney Dis. 2021 Mar;77(3):440-453. doi: 10.1053/j.ajkd.2020.10.009. Epub 2021 Jan 21. Am J Kidney Dis. 2021. PMID: 33487481 Review.
Obesity induced Ext1 reduction mediates the occurrence of NAFLD.
Wang M, Li B, Qin F, Ye J, Jin L. Wang M, et al. Biochem Biophys Res Commun. 2022 Jan 22;589:123-130. doi: 10.1016/j.bbrc.2021.12.017. Epub 2021 Dec 7. Biochem Biophys Res Commun. 2022. PMID: 34906902
Loss-of-function mutations in Ext1 link to hereditary multiple exostosis (HME). The present research was undertaken to identify the effect of Ext1 in the progress of NAFLD. High-fat-diet induced mice obesity, hepatic steatosis and decreased hepatic Ext1 expre …
Loss-of-function mutations in Ext1 link to hereditary multiple exostosis (HME). The present research was undertaken to identify the e …
EXT1 and NCAM1-associated membranous lupus nephritis in a cohort of patients undergoing repeat kidney biopsies.
Miller PP, Caza T, Larsen CP, Charu V. Miller PP, et al. Nephrol Dial Transplant. 2023 Feb 13;38(2):396-404. doi: 10.1093/ndt/gfac058. Nephrol Dial Transplant. 2023. PMID: 35278072 Free PMC article.
RESULTS: We identified 31 patients with a clinical diagnosis of SLE and at least two kidney biopsies with MLN. A total of 28 patients (90%) showed concordant staining for EXT1 and NCAM1 in both biopsies; 8 patients (26%) were EXT1 positive and NCAM1 negative, 18 pat …
RESULTS: We identified 31 patients with a clinical diagnosis of SLE and at least two kidney biopsies with MLN. A total of 28 patients (90%) …
Exostosin 1/Exostosin 2-Associated Membranous Nephropathy.
Sethi S, Madden BJ, Debiec H, Charlesworth MC, Gross L, Ravindran A, Hummel AM, Specks U, Fervenza FC, Ronco P. Sethi S, et al. J Am Soc Nephrol. 2019 Jun;30(6):1123-1136. doi: 10.1681/ASN.2018080852. Epub 2019 May 6. J Am Soc Nephrol. 2019. PMID: 31061139 Free PMC article.
Immunohistochemistry staining revealed bright granular GBM staining for EXT1 and EXT2. Clinical and biopsy findings showed features of autoimmune disease, including lupus, in 80.7% of the 26 EXT1/EXT2-associated MN cases we identified. ...Tests in seven patients wit …
Immunohistochemistry staining revealed bright granular GBM staining for EXT1 and EXT2. Clinical and biopsy findings showed features o …
EXT1 methylation promotes proliferation and migration and predicts the clinical outcome of non-small cell lung carcinoma via WNT signalling pathway.
Kong W, Chen Y, Zhao Z, Zhang L, Lin X, Luo X, Wang S, Song Z, Lin X, Lai G, Yu Z. Kong W, et al. J Cell Mol Med. 2021 Mar;25(5):2609-2620. doi: 10.1111/jcmm.16277. Epub 2021 Feb 9. J Cell Mol Med. 2021. PMID: 33565239 Free PMC article.
Knocking down of EXT1 resulted in decreased proliferation and migration. EXT1 targets were analysed using GSEA. It is found that the WNT signalling is the potential downstream target of EXT1. Further analyses revealed that the EXT1 targets the beta-cat …
Knocking down of EXT1 resulted in decreased proliferation and migration. EXT1 targets were analysed using GSEA. It is found th …
Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood.
Borcherding N, Jia W, Giwa R, Field RL, Moley JR, Kopecky BJ, Chan MM, Yang BQ, Sabio JM, Walker EC, Osorio O, Bredemeyer AL, Pietka T, Alexander-Brett J, Morley SC, Artyomov MN, Abumrad NA, Schilling J, Lavine K, Crewe C, Brestoff JR. Borcherding N, et al. Cell Metab. 2022 Oct 4;34(10):1499-1513.e8. doi: 10.1016/j.cmet.2022.08.010. Epub 2022 Sep 6. Cell Metab. 2022. PMID: 36070756 Free PMC article.
EXT1, Regulated by MiR-665, Promotes Cell Apoptosis via ERK1/2 Signaling Pathway in Acute Lymphoblastic Leukemia.
Liu NW, Huang X, Liu S, Lu Y. Liu NW, et al. Med Sci Monit. 2019 Aug 29;25:6491-6503. doi: 10.12659/MSM.918295. Med Sci Monit. 2019. PMID: 31465316 Free PMC article.
Our study showed that EXT1 modulates the proliferation and apoptosis of ALL cells in vitro and in vivo and that miR-665 promotes cell growth and inhibits apoptosis by suppressing EXT1. EXT1 promotes cell apoptosis via deactivating the ERK1/2 pathway. ...
Our study showed that EXT1 modulates the proliferation and apoptosis of ALL cells in vitro and in vivo and that miR-665 promotes cell …
Mutation spectrum of EXT1 and EXT2 in the Saudi patients with hereditary multiple exostoses.
Al-Zayed Z, Al-Rijjal RA, Al-Ghofaili L, BinEssa HA, Pant R, Alrabiah A, Al-Hussainan T, Zou M, Meyer BF, Shi Y. Al-Zayed Z, et al. Orphanet J Rare Dis. 2021 Feb 25;16(1):100. doi: 10.1186/s13023-021-01738-z. Orphanet J Rare Dis. 2021. PMID: 33632255 Free PMC article.
In total, EXT1 and EXT2 mutations were found in 77% (13/17) of Saudi HME patients. CONCLUSION: EXT1 and EXT2 mutations contribute significantly to the pathogenesis of HME in the Saudi population. ...
In total, EXT1 and EXT2 mutations were found in 77% (13/17) of Saudi HME patients. CONCLUSION: EXT1 and EXT2 mutations contrib …
581 results