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Page 1
Eya1 protein distribution during embryonic development of Xenopus laevis.
Almasoudi SH, Schlosser G. Almasoudi SH, et al. Gene Expr Patterns. 2021 Dec;42:119213. doi: 10.1016/j.gep.2021.119213. Epub 2021 Sep 15. Gene Expr Patterns. 2021. PMID: 34536585 Free article.
At present, most of our knowledge of Eya1 distribution is based on in situ hybridization for Eya1 mRNA. ...Here we report the localization of Eya1 protein throughout embryonic development from neural plate stages to tadpole stages of Xenopus laevis using a sp …
At present, most of our knowledge of Eya1 distribution is based on in situ hybridization for Eya1 mRNA. ...Here we report the …
EYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner ear.
Wong EY, Ahmed M, Xu PX. Wong EY, et al. Hear Res. 2013 Mar;297:13-9. doi: 10.1016/j.heares.2012.09.009. Epub 2012 Oct 24. Hear Res. 2013. PMID: 23104013 Free PMC article. Review.
Mutations of the Eya1 and Six1 genes cause profound developmental auditory defects in mice and humans. The molecular mechanisms and developmental processes controlled by the EYA1 and SIX1 complex in inner ear development and neurosensory fate induction are the focus …
Mutations of the Eya1 and Six1 genes cause profound developmental auditory defects in mice and humans. The molecular mechanisms and d …
EYA1-related disorders: two clinical cases and a literature review.
Castiglione A, Melchionda S, Carella M, Trevisi P, Bovo R, Manara R, Martini A. Castiglione A, et al. Int J Pediatr Otorhinolaryngol. 2014 Aug;78(8):1201-10. doi: 10.1016/j.ijporl.2014.03.032. Epub 2014 Apr 12. Int J Pediatr Otorhinolaryngol. 2014. PMID: 24803398 Review.
We also identified a novel sporadic missense mutation in the EYA1 gene: p.G533R (c.1597G>A, NM_000503.4), a highly conserved, heterozygotic amino acid substitution. ...CONCLUSIONS: Our results demonstrate the importance of considering the imaging evaluation and the comp …
We also identified a novel sporadic missense mutation in the EYA1 gene: p.G533R (c.1597G>A, NM_000503.4), a highly conserved, hete …
EYA1 promotes cell migration and tumor metastasis in hepatocellular carcinoma.
Kong D, Ma W, Zhang D, Cui Q, Wang K, Tang J, Liu Z, Wu G. Kong D, et al. Am J Transl Res. 2019 Apr 15;11(4):2328-2338. eCollection 2019. Am J Transl Res. 2019. PMID: 31105839 Free PMC article.
Collectively, this study suggested that EYA1 activated FNDC3B to promote the migration and invasion in HCC. The aberrant expressions of EYA1 and FNDC3B may become the poor predictors for HCC patients....
Collectively, this study suggested that EYA1 activated FNDC3B to promote the migration and invasion in HCC. The aberrant expressions …
Expression of Eya1 in mouse taste buds.
Ohmoto M, Kitamoto S, Hirota J. Ohmoto M, et al. Cell Tissue Res. 2021 Mar;383(3):979-986. doi: 10.1007/s00441-020-03311-9. Epub 2020 Nov 26. Cell Tissue Res. 2021. PMID: 33242174
In situ hybridization revealed that Eya1 was predominantly expressed in bitter cells and also in the putative immature/differentiating taste bud cells in circumvallate and fungiform papillae and soft palate. Eya1 is a candidate molecule that regulates the generation …
In situ hybridization revealed that Eya1 was predominantly expressed in bitter cells and also in the putative immature/differentiatin …
EYA1 promotes tumor angiogenesis by activating the PI3K pathway in colorectal cancer.
Cai S, Cheng X, Liu Y, Lin Z, Zeng W, Yang C, Liu L, Chukwuebuka OA, Li W. Cai S, et al. Exp Cell Res. 2018 Jun 1;367(1):37-46. doi: 10.1016/j.yexcr.2018.02.028. Epub 2018 Feb 27. Exp Cell Res. 2018. PMID: 29496520
Moreover, data indicated that the enhancement of HIF-1alpha expression by Eya1 depended on its ability to activate the phosphatidylinositol 3-kinase (PI3K) signaling pathways to increase the phosphorylation of AKT subunits. Overexpression of Eya1 increased tumor ang …
Moreover, data indicated that the enhancement of HIF-1alpha expression by Eya1 depended on its ability to activate the phosphatidylin …
SIX1/EYA1 are novel liver damage biomarkers in chronic hepatitis B and other liver diseases.
Xu B, Yang Q, Tang Y, Tan Z, Fu H, Peng J, Xiang X, Gan L, Deng G, Mao Q, Xu PX, Jiang Y, Ding J. Xu B, et al. Ann Transl Med. 2021 Jun;9(12):992. doi: 10.21037/atm-21-2526. Ann Transl Med. 2021. PMID: 34277792 Free PMC article.
Dynamic observation of these proteins over time in 35 selected CHB patients revealed that SIX1 and EYA1 serum levels increased over an interval. Immunofluorescent staining revealed that both SIX1 and EYA1 were only expressed in hepatic stellate cells (HSCs), and the …
Dynamic observation of these proteins over time in 35 selected CHB patients revealed that SIX1 and EYA1 serum levels increased over a …
The value of EYA1/3/4 in clear cell renal cell carcinoma: a study from multiple databases.
Liu T, Nie J, Zhang X, Deng X, Fu B. Liu T, et al. Sci Rep. 2023 May 8;13(1):7442. doi: 10.1038/s41598-023-34324-3. Sci Rep. 2023. PMID: 37156847 Free PMC article.
The level of expression of the EYA1/3/4 gene was significantly correlated with the prognosis and clinicopathological parameters of ccRCC patients. ...The increased expression of EYA1 might play an important role in ccRCC oncogenesis, and the decreased expression of …
The level of expression of the EYA1/3/4 gene was significantly correlated with the prognosis and clinicopathological parameters of cc …
The Eya1 Phosphatase Mediates Shh-Driven Symmetric Cell Division of Cerebellar Granule Cell Precursors.
Merk DJ, Zhou P, Cohen SM, Pazyra-Murphy MF, Hwang GH, Rehm KJ, Alfaro J, Reid CM, Zhao X, Park E, Xu PX, Chan JA, Eck MJ, Nazemi KJ, Harwell CC, Segal RA. Merk DJ, et al. Dev Neurosci. 2020;42(5-6):170-186. doi: 10.1159/000512976. Epub 2021 Jan 20. Dev Neurosci. 2020. PMID: 33472197 Free PMC article.
We identify atypical protein kinase C (aPKC) as a direct target of Eya1 activity and show that Eya1 dephosphorylates a critical threonine (T410) in the activation loop. ...This Eya1-dependent cascade is critical in linking spindle orientation, cell cycle exit …
We identify atypical protein kinase C (aPKC) as a direct target of Eya1 activity and show that Eya1 dephosphorylates a critica …
The transcriptional coactivator Eya1 exerts transcriptional repressive activity by interacting with REST corepressors and REST-binding sequences to maintain nephron progenitor identity.
Li J, Cheng C, Xu J, Zhang T, Tokat B, Dolios G, Ramakrishnan A, Shen L, Wang R, Xu PX. Li J, et al. Nucleic Acids Res. 2022 Oct 14;50(18):10343-10359. doi: 10.1093/nar/gkac760. Nucleic Acids Res. 2022. PMID: 36130284 Free PMC article.
Eya1 is critical for establishing and maintaining nephron progenitor cells (NPCs). ...Intriguingly, we identified REST-binding motifs in 76% of Eya1-occupied sites without H3K27ac-deposition, which were present in many Eya1 target genes upregulated in Eya1 …
Eya1 is critical for establishing and maintaining nephron progenitor cells (NPCs). ...Intriguingly, we identified REST-binding motifs …
457 results