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Microglia Depletion Reduces Human Neuronal APOE4-Driven Pathologies in a Chimeric Alzheimer's Disease Model.
bioRxiv [Preprint]. 2023 Nov 14:2023.11.10.566510. doi: 10.1101/2023.11.10.566510.
bioRxiv. 2023.
PMID: 38014339
Free PMC article.
Preprint.
The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.
Nelson MR, Liu P, Agrawal A, Yip O, Blumenfeld J, Traglia M, Kim MJ, Koutsodendris N, Rao A, Grone B, Hao Y, Yoon SY, Xu Q, De Leon S, Choenyi T, Thomas R, Lopera F, Quiroz YT, Arboleda-Velasquez JF, Reiman EM, Mahley RW, Huang Y.
Nelson MR, et al.
Nat Neurosci. 2023 Dec;26(12):2104-2121. doi: 10.1038/s41593-023-01480-8. Epub 2023 Nov 13.
Nat Neurosci. 2023.
PMID: 37957317
Free PMC article.
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APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release.
Koutsodendris N, Blumenfeld J, Agrawal A, Traglia M, Yip O, Rao A, Kim MJ, Nelson MR, Wang YH, Grone B, Hao Y, Thomas R, Zilberter M, Yoon SY, Arriola P, Huang Y.
Koutsodendris N, et al.
Cell Rep. 2023 Oct 31;42(10):113252. doi: 10.1016/j.celrep.2023.113252. Epub 2023 Oct 19.
Cell Rep. 2023.
PMID: 37863057
Free PMC article.
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Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits.
Koutsodendris N, Blumenfeld J, Agrawal A, Traglia M, Grone B, Zilberter M, Yip O, Rao A, Nelson MR, Hao Y, Thomas R, Yoon SY, Arriola P, Huang Y.
Koutsodendris N, et al.
Nat Aging. 2023 Mar;3(3):275-296. doi: 10.1038/s43587-023-00368-3. Epub 2023 Feb 20.
Nat Aging. 2023.
PMID: 37118426
Free PMC article.
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