Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2012 2
2017 2
2018 1
2019 2
2020 5
2021 3
2022 2
2023 5
2024 3

Text availability

Article attribute

Article type

Publication date

Search Results

22 results

Results by year

Filters applied: . Clear all
Page 1
Functions and evolution of FAM111 serine proteases.
Welter AL, Machida YJ. Welter AL, et al. Front Mol Biosci. 2022 Dec 15;9:1081166. doi: 10.3389/fmolb.2022.1081166. eCollection 2022. Front Mol Biosci. 2022. PMID: 36589246 Free PMC article. Review.
FAM111A localizes to nascent DNA and plays a role at the DNA replication fork. ...FAM111A also has a paralog, FAM111B, a serine protease with unknown cellular functions. ...
FAM111A localizes to nascent DNA and plays a role at the DNA replication fork. ...FAM111A also has a paralog, FAM111B, a serin …
FAM111A regulates replication origin activation and cell fitness.
Rios-Szwed DO, Alvarez V, Sanchez-Pulido L, Garcia-Wilson E, Jiang H, Bandau S, Lamond A, Alabert C. Rios-Szwed DO, et al. Life Sci Alliance. 2023 Oct 4;6(12):e202302111. doi: 10.26508/lsa.202302111. Print 2023 Dec. Life Sci Alliance. 2023. PMID: 37793778 Free PMC article.
However, FAM111A functions remain unclear. Here, we show that FAM111A facilitates efficient activation of DNA replication origins. ...Unrestrained expression of FAM111A WT also causes increased single-stranded DNA formation that relies on S phase entry, FA …
However, FAM111A functions remain unclear. Here, we show that FAM111A facilitates efficient activation of DNA replication orig …
FAM111A induces nuclear dysfunction in disease and viral restriction.
Nie M, Oravcová M, Jami-Alahmadi Y, Wohlschlegel JA, Lazzerini-Denchi E, Boddy MN. Nie M, et al. EMBO Rep. 2021 Feb 3;22(2):e50803. doi: 10.15252/embr.202050803. Epub 2020 Dec 28. EMBO Rep. 2021. PMID: 33369867 Free PMC article.
In addition, FAM111A was identified as a restriction factor for certain host range mutants of the SV40 polyomavirus and VACV orthopoxvirus. ...In this regard, we identify nucleoporins and the associated GANP transcription/replication factor as FAM111A interactors an …
In addition, FAM111A was identified as a restriction factor for certain host range mutants of the SV40 polyomavirus and VACV orthopox …
N(6) -methyladenosine-modified FAM111A-DT promotes hepatocellular carcinoma growth via epigenetically activating FAM111A.
Pu J, Xu Z, Huang Y, Nian J, Yang M, Fang Q, Wei Q, Huang Z, Liu G, Wang J, Wu X, Wei H. Pu J, et al. Cancer Sci. 2023 Sep;114(9):3649-3665. doi: 10.1111/cas.15886. Epub 2023 Jul 3. Cancer Sci. 2023. PMID: 37400994 Free PMC article.
Mutation of m(6) A sites on FAM111A-DT abolished the roles of FAM111A-DT. Mechanistic investigations found that m(6) A-modified FAM111A-DT bound to FAM111A promoter and also interacted with m(6) A reader YTHDC1, which further bound and recruited histon …
Mutation of m(6) A sites on FAM111A-DT abolished the roles of FAM111A-DT. Mechanistic investigations found that m(6) A-modifie …
FAM111A protects replication forks from protein obstacles via its trypsin-like domain.
Kojima Y, Machida Y, Palani S, Caulfield TR, Radisky ES, Kaufmann SH, Machida YJ. Kojima Y, et al. Nat Commun. 2020 Mar 12;11(1):1318. doi: 10.1038/s41467-020-15170-7. Nat Commun. 2020. PMID: 32165630 Free PMC article.
This function of FAM111A requires an intact trypsin-like protease domain, the PCNA interaction, and the DNA-binding domain that is necessary for protease activity in vivo. ...Altogether, our findings reveal a role of FAM111A in overcoming protein obstacles to replic …
This function of FAM111A requires an intact trypsin-like protease domain, the PCNA interaction, and the DNA-binding domain that is ne …
Editorial: The repair of DNA-protein crosslinks.
Sun Y, Nitiss JL, Pommier Y. Sun Y, et al. Front Mol Biosci. 2023 Apr 28;10:1203479. doi: 10.3389/fmolb.2023.1203479. eCollection 2023. Front Mol Biosci. 2023. PMID: 37187895 Free PMC article. No abstract available.
Unravelling the Intricate Roles of FAM111A and FAM111B: From Protease-Mediated Cellular Processes to Disease Implications.
Naicker D, Rhoda C, Sunda F, Arowolo A. Naicker D, et al. Int J Mol Sci. 2024 Feb 29;25(5):2845. doi: 10.3390/ijms25052845. Int J Mol Sci. 2024. PMID: 38474092 Free PMC article. Review.
Additionally, FAM111A functions as an antiviral factor against DNA and RNA viruses. ...FAM111A and FAM111B dysregulation are linked to genetic disorders: Kenny-Caffey Syndrome type 2 and Gracile Bone Dysplasia for FAM111A and POIKTMP, respectively, and can …
Additionally, FAM111A functions as an antiviral factor against DNA and RNA viruses. ...FAM111A and FAM111B dysregulation are l …
DNA-protein crosslink proteases in genome stability.
Ruggiano A, Ramadan K. Ruggiano A, et al. Commun Biol. 2021 Jan 4;4(1):11. doi: 10.1038/s42003-020-01539-3. Commun Biol. 2021. PMID: 33398053 Free PMC article. Review.
Here, we discuss the importance of DPC proteases in DNA replication, genome stability and their direct link to human diseases and cancer therapy....
Here, we discuss the importance of DPC proteases in DNA replication, genome stability and their direct link to human diseases and cancer …
Contribution of DNA Replication to the FAM111A-Mediated Simian Virus 40 Host Range Phenotype.
Tarnita RM, Wilkie AR, DeCaprio JA. Tarnita RM, et al. J Virol. 2018 Dec 10;93(1):e01330-18. doi: 10.1128/JVI.01330-18. Print 2019 Jan 1. J Virol. 2018. PMID: 30333173 Free PMC article.
Furthermore, while FAM111A localized to nucleoli in uninfected cells in a cell cycle-dependent manner, FAM111A relocalized to viral replication centers after infection with SV40 wild-type or HR viruses. ...Our findings regarding the role of FAM111A in restric …
Furthermore, while FAM111A localized to nucleoli in uninfected cells in a cell cycle-dependent manner, FAM111A relocalized to …
Study on the role and pharmacology of cuproptosis in gastric cancer.
Jiang L, Liao J, Han Y. Jiang L, et al. Front Oncol. 2023 Mar 17;13:1145446. doi: 10.3389/fonc.2023.1145446. eCollection 2023. Front Oncol. 2023. PMID: 37007099 Free PMC article.
OBJECTIVE: Gastric cancer has a poor prognosis and high mortality. Cuproptosis, a novel programmed cell death, is rarely studied in gastric cancer. ...RESULTS: We have established the early diagnosis model of eight characteristic genes (ENTPD3, PDZD4, CNN1, GTPBP4, …
OBJECTIVE: Gastric cancer has a poor prognosis and high mortality. Cuproptosis, a novel programmed cell death, is rarely studied in g …
22 results