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Did you mean fam cancer (5,770 results)?
ACSL family: The regulatory mechanisms and therapeutic implications in cancer.
Quan J, Bode AM, Luo X. Quan J, et al. Eur J Pharmacol. 2021 Oct 15;909:174397. doi: 10.1016/j.ejphar.2021.174397. Epub 2021 Jul 29. Eur J Pharmacol. 2021. PMID: 34332918 Review.
Accumulating evidence shows that deregulation of fatty acid (FA) metabolism is associated with the development of cancer. Long-chain acyl-coenzyme A synthases (ACSLs) are responsible for activating long-chain FAs and are frequently deregulated in cancers. ... …
Accumulating evidence shows that deregulation of fatty acid (FA) metabolism is associated with the development of cancer. Long-chain …
FOXO Signaling Pathways as Therapeutic Targets in Cancer.
Farhan M, Wang H, Gaur U, Little PJ, Xu J, Zheng W. Farhan M, et al. Int J Biol Sci. 2017 Jul 6;13(7):815-827. doi: 10.7150/ijbs.20052. eCollection 2017. Int J Biol Sci. 2017. PMID: 28808415 Free PMC article. Review.
These pathways regulate different physiological processes and pathological events, such as cancer and other diseases. The Forkhead box O (FOXO) is one subfamily of the fork head transcription factor family with important roles in cell fate decisions and this subfamily is a …
These pathways regulate different physiological processes and pathological events, such as cancer and other diseases. The Forkhead bo …
KRAS(G12D) inhibition in pancreatic cancer: Fas expression facilitates immune clearance.
Yeh C, Park W, Yaeger R. Yeh C, et al. Dev Cell. 2023 Sep 11;58(17):1515-1516. doi: 10.1016/j.devcel.2023.08.020. Dev Cell. 2023. PMID: 37699334
In an article in this issue of Developmental Cell and in a second paper in Cancer Cell, Mahadevan et al. demonstrate that Kras(G12D) suppression remodels the immunosuppressive microenvironment of Kras(G12D) pancreatic cancers, recruits activated CD8(+) cytotoxic T c …
In an article in this issue of Developmental Cell and in a second paper in Cancer Cell, Mahadevan et al. demonstrate that Kras(G12D) …
Serpins promote cancer cell survival and vascular co-option in brain metastasis.
Valiente M, Obenauf AC, Jin X, Chen Q, Zhang XH, Lee DJ, Chaft JE, Kris MG, Huse JT, Brogi E, Massagué J. Valiente M, et al. Cell. 2014 Feb 27;156(5):1002-16. doi: 10.1016/j.cell.2014.01.040. Cell. 2014. PMID: 24581498 Free PMC article.
Brain metastasis is an ominous complication of cancer, yet most cancer cells that infiltrate the brain die of unknown causes. ...By protecting cancer cells from death signals and fostering vascular co-option, anti-PA serpins provide a unifying mechanism for t …
Brain metastasis is an ominous complication of cancer, yet most cancer cells that infiltrate the brain die of unknown causes. …
FAS-1377 G/A (rs2234767) polymorphism and cancer susceptibility: a meta-analysis of 17,858 cases and 24,311 controls.
Zhong-Xing Z, Yuan-Yuan M, Hai Zhen M, Jian-Gang Z, Li-Feng Z. Zhong-Xing Z, et al. PLoS One. 2013 Aug 27;8(8):e73700. doi: 10.1371/journal.pone.0073700. eCollection 2013. PLoS One. 2013. PMID: 24014103 Free PMC article. Review.
Specifically, various single-nucleotide polymorphisms (SNPs) in apoptotic genes, such as FAS-1377 G/A SNP, have been associated with cancer risk. FAS-1377 G/A SNP has been shown to alter FAS gene promoter transcriptional activity. Down-regulation of …
Specifically, various single-nucleotide polymorphisms (SNPs) in apoptotic genes, such as FAS-1377 G/A SNP, have been associated with …
Targeting the Fas/Fas ligand pathway in cancer.
O'Brien DI, Nally K, Kelly RG, O'Connor TM, Shanahan F, O'Connell J. O'Brien DI, et al. Expert Opin Ther Targets. 2005 Oct;9(5):1031-44. doi: 10.1517/14728222.9.5.1031. Expert Opin Ther Targets. 2005. PMID: 16185156 Review.
Fas is a transmembrane receptor that can induce apoptosis after cross-linking with either agonistic antibodies or with Fas ligand (FasL). ...This review summarises the current understanding of the Fas/FasL system in tumorigenesis and discusses attempts to uti …
Fas is a transmembrane receptor that can induce apoptosis after cross-linking with either agonistic antibodies or with Fas lig …
Lipid rafts and Fas/CD95 signaling in cancer chemotherapy.
Gajate C, Mollinedo F. Gajate C, et al. Recent Pat Anticancer Drug Discov. 2011 Sep;6(3):274-83. doi: 10.2174/157489211796957766. Recent Pat Anticancer Drug Discov. 2011. PMID: 21762074 Free article. Review.
The alkyl-lysophospholipid analogue edelfosine was the first antitumor drug reported to induce apoptosis in cancer cells through co-clustering of lipid rafts and Fas/CD95 death receptor. ...On these grounds, lipid rafts have become an appealing and promising target …
The alkyl-lysophospholipid analogue edelfosine was the first antitumor drug reported to induce apoptosis in cancer cells through co-c …
Targeting the Fas/FasL signaling pathway in cancer therapy.
Villa-Morales M, Fernández-Piqueras J. Villa-Morales M, et al. Expert Opin Ther Targets. 2012 Jan;16(1):85-101. doi: 10.1517/14728222.2011.628937. Epub 2012 Jan 12. Expert Opin Ther Targets. 2012. PMID: 22239437 Review.
INTRODUCTION: The Fas/FasL system plays a significant role in tumorigenesis. Research has shown that its impairment in cancer cells may lead to apoptosis resistance and contribute to tumor progression. Thus, the development of effective therapies targeting the Fa …
INTRODUCTION: The Fas/FasL system plays a significant role in tumorigenesis. Research has shown that its impairment in cancer …
Fas and TRAIL 'death receptors' as initiators of inflammation: Implications for cancer.
Cullen SP, Martin SJ. Cullen SP, et al. Semin Cell Dev Biol. 2015 Mar;39:26-34. doi: 10.1016/j.semcdb.2015.01.012. Epub 2015 Feb 2. Semin Cell Dev Biol. 2015. PMID: 25655947 Review.
Moreover, the expression of Fas and TRAIL receptors is greatly elevated in many cancer types such as hepatocellular carcinoma, renal carcinoma and ovarian cancer, suggesting that such tumors benefit from the expression of these receptors. ...Thus, the charact …
Moreover, the expression of Fas and TRAIL receptors is greatly elevated in many cancer types such as hepatocellular carcinoma, …
Caspase-8: The double-edged sword.
Mandal R, Barrón JC, Kostova I, Becker S, Strebhardt K. Mandal R, et al. Biochim Biophys Acta Rev Cancer. 2020 Apr;1873(2):188357. doi: 10.1016/j.bbcan.2020.188357. Epub 2020 Mar 5. Biochim Biophys Acta Rev Cancer. 2020. PMID: 32147543 Review.
Low expression levels of pro-Caspase-8 is therefore associated with the malignant transformation of cancers. However, the long-held notion that pro-Caspase-8 expression/activity is generally lost in most cancers, thereby contributing to apoptotic escape and enhanced …
Low expression levels of pro-Caspase-8 is therefore associated with the malignant transformation of cancers. However, the long-held n …
11,251 results
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