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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 4
1988 7
1989 3
1990 19
1991 63
1992 76
1993 88
1994 107
1995 126
1996 122
1997 142
1998 136
1999 164
2000 160
2001 206
2002 214
2003 196
2004 189
2005 187
2006 196
2007 159
2008 151
2009 144
2010 154
2011 154
2012 159
2013 158
2014 146
2015 166
2016 148
2017 149
2018 135
2019 123
2020 141
2021 112
2022 92
2023 103
2024 44

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4,514 results

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Page 1
Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy.
Li G, Choi JE, Kryczek I, Sun Y, Liao P, Li S, Wei S, Grove S, Vatan L, Nelson R, Schaefer G, Allen SG, Sankar K, Fecher LA, Mendiratta-Lala M, Frankel TL, Qin A, Waninger JJ, Tezel A, Alva A, Lao CD, Ramnath N, Cieslik M, Harms PW, Green MD, Chinnaiyan AM, Zou W. Li G, et al. Cancer Cell. 2023 Feb 13;41(2):304-322.e7. doi: 10.1016/j.ccell.2022.12.008. Epub 2023 Jan 12. Cancer Cell. 2023. PMID: 36638784 Free PMC article.
Immune checkpoint blockade (ICB) can produce durable responses against cancer. We and others have found that a subset of patients experiences paradoxical rapid cancer progression during immunotherapy. ...Interestingly, patients with HPD but not CR exhibit elevated t …
Immune checkpoint blockade (ICB) can produce durable responses against cancer. We and others have found that a subset of patients exp …
Targeting FAPalpha-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models.
Qi M, Fan S, Huang M, Pan J, Li Y, Miao Q, Lyu W, Li X, Deng L, Qiu S, Liu T, Deng W, Chu X, Jiang C, He W, Xia L, Yang Y, Hong J, Qi Q, Yin W, Liu X, Shi C, Chen M, Ye W, Zhang D. Qi M, et al. J Clin Invest. 2022 Oct 3;132(19):e157399. doi: 10.1172/JCI157399. J Clin Invest. 2022. PMID: 35951441 Free PMC article.
Vessel co-option has been demonstrated to mediate colorectal cancer liver metastasis (CRCLM) resistance to antiangiogenic therapy. ...Gain- or loss-of-function experiments revealed that the bevacizumab-resistant tumor cell-derived FGFBP1 induced FAPalpha expression by enha …
Vessel co-option has been demonstrated to mediate colorectal cancer liver metastasis (CRCLM) resistance to antiangiogenic therapy. .. …
ZFP281 drives a mesenchymal-like dormancy program in early disseminated breast cancer cells that prevents metastatic outgrowth in the lung.
Nobre AR, Dalla E, Yang J, Huang X, Wullkopf L, Risson E, Razghandi P, Anton ML, Zheng W, Seoane JA, Curtis C, Kenigsberg E, Wang J, Aguirre-Ghiso JA. Nobre AR, et al. Nat Cancer. 2022 Oct;3(10):1165-1180. doi: 10.1038/s43018-022-00424-8. Epub 2022 Sep 1. Nat Cancer. 2022. PMID: 36050483
Increasing evidence shows that cancer cells can disseminate from early evolved primary lesions much earlier than the classical metastasis models predicted. ...We found that ZFP281 not only controls the early dissemination of cancer cells but also locks early DCCs in …
Increasing evidence shows that cancer cells can disseminate from early evolved primary lesions much earlier than the classical metast …
FGF2: a novel druggable target for glioblastoma?
Jimenez-Pascual A, Mitchell K, Siebzehnrubl FA, Lathia JD. Jimenez-Pascual A, et al. Expert Opin Ther Targets. 2020 Apr;24(4):311-318. doi: 10.1080/14728222.2020.1736558. Epub 2020 Mar 16. Expert Opin Ther Targets. 2020. PMID: 32174197 Free PMC article. Review.
Introduction: Fibroblast growth factors (FGFs) are key mitogens in tissue homeostasis and cancer. FGF2 regulates self-renewal of multiple stem-cell types, is widely used in stem cell culture paradigms and has been adopted for cultivating the growth of cancer …
Introduction: Fibroblast growth factors (FGFs) are key mitogens in tissue homeostasis and cancer. FGF2 regulates self-renewal …
The FGF2 aptamer inhibits the growth of FGF2-FGFR pathway driven lung cancer cells.
Hamamoto J, Yasuda H, Nonaka Y, Fujiwara M, Nakamura Y, Soejima K, Betsuyaku T. Hamamoto J, et al. Biochem Biophys Res Commun. 2018 Sep 10;503(3):1330-1334. doi: 10.1016/j.bbrc.2018.07.044. Epub 2018 Jul 11. Biochem Biophys Res Commun. 2018. PMID: 30005872
Cancers, including lung cancer, are a leading cause of death worldwide. ...Our results show that the FGF2 aptamer inhibits the growth of FGF2-FGFR pathway-dependent lung cancer cells. ...
Cancers, including lung cancer, are a leading cause of death worldwide. ...Our results show that the FGF2 aptamer inhib …
Cancer-associated fibroblasts promote gastric cancer cell proliferation by paracrine FGF2-driven ribosome biogenesis.
Li D, Huang P, Xia L, Leng W, Qin S. Li D, et al. Int Immunopharmacol. 2024 Apr 20;131:111836. doi: 10.1016/j.intimp.2024.111836. Epub 2024 Mar 12. Int Immunopharmacol. 2024. PMID: 38479160
The cancer-associated fibroblast (CAF)-derived secretome plays critical roles in tumor progression by remodelling tumor microenvironment. ...Our finding provides evidence that targeting blockade of CAF-derived FGF2 protein might be a promising treatment for GC....
The cancer-associated fibroblast (CAF)-derived secretome plays critical roles in tumor progression by remodelling tumor microenvironm …
FGF2 induces breast cancer growth through ligand-independent activation and recruitment of ERalpha and PRBdelta4 isoform to MYC regulatory sequences.
Giulianelli S, Riggio M, Guillardoy T, Pérez Piñero C, Gorostiaga MA, Sequeira G, Pataccini G, Abascal MF, Toledo MF, Jacobsen BM, Guerreiro AC, Barros A, Novaro V, Monteiro FL, Amado F, Gass H, Abba M, Helguero LA, Lanari C. Giulianelli S, et al. Int J Cancer. 2019 Oct 1;145(7):1874-1888. doi: 10.1002/ijc.32252. Epub 2019 Mar 28. Int J Cancer. 2019. PMID: 30843188 Free article.
Here, we show that fibroblast growth factor 2 (FGF2)-induces cell proliferation and tumor growth through hormone-independent ERalpha and PR activation and their interaction at the MYC enhancer and proximal promoter. ...PRBdelta4 lacks the hormon …
Here, we show that fibroblast growth factor 2 (FGF2)-induces cell proliferation and tumor growth through …
Increased High Molecular Weight FGF2 in Endocrine-Resistant Breast Cancer.
Sahores A, Figueroa V, May M, Liguori M, Rubstein A, Fuentes C, Jacobsen BM, Elía A, Rojas P, Sequeira GR, Álvarez MM, González P, Gass H, Hewitt S, Molinolo A, Lanari C, Lamb CA. Sahores A, et al. Horm Cancer. 2018 Oct;9(5):338-348. doi: 10.1007/s12672-018-0339-4. Epub 2018 Jun 28. Horm Cancer. 2018. PMID: 29956066 Free PMC article.
Endocrine resistance may develop as a consequence of enhanced growth factor signaling. Fibroblast growth factor 2 (FGF2) consists of a low and several high molecular weight forms (HMW-FGF2). ...We assessed FGF2 expression and local …
Endocrine resistance may develop as a consequence of enhanced growth factor signaling. Fibroblast growth factor 2 …
Clinical significance of miR-139-5p and FGF2 in ovarian cancer.
Meijuan W, Mao X, Wang S. Meijuan W, et al. J BUON. 2021 May-Jun;26(3):663-669. J BUON. 2021. PMID: 34268918 Free article.
PURPOSE: To estimate the expression and clinical significance of miR-139-5p and fibroblast growth factor 2 (FGF2) in ovarian cancer (OC). METHODS: Of the 198 female patients undergoing surgical treatment in our hospital, 101 patients with …
PURPOSE: To estimate the expression and clinical significance of miR-139-5p and fibroblast growth factor 2 (F …
FGF-2 signaling in nasopharyngeal carcinoma modulates pericyte-macrophage crosstalk and metastasis.
Wang Y, Sun Q, Ye Y, Sun X, Xie S, Zhan Y, Song J, Fan X, Zhang B, Yang M, Lv L, Hosaka K, Yang Y, Nie G. Wang Y, et al. JCI Insight. 2022 May 23;7(10):e157874. doi: 10.1172/jci.insight.157874. JCI Insight. 2022. PMID: 35439170 Free PMC article.
In particular, the role of vascular pericytes, a critical cellular component in the TME, in cancer invasion and metastasis warrants further investigation. Here, we report that an elevation of FGF-2 signaling in samples from patients with nasopharyngeal carcinoma (NPC) and …
In particular, the role of vascular pericytes, a critical cellular component in the TME, in cancer invasion and metastasis warrants f …
4,514 results