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Page 1
Childhood intelligence is heritable, highly polygenic and associated with FNBP1L.
Benyamin B, Pourcain B, Davis OS, Davies G, Hansell NK, Brion MJ, Kirkpatrick RM, Cents RA, Franić S, Miller MB, Haworth CM, Meaburn E, Price TS, Evans DM, Timpson N, Kemp J, Ring S, McArdle W, Medland SE, Yang J, Harris SE, Liewald DC, Scheet P, Xiao X, Hudziak JJ, de Geus EJ; Wellcome Trust Case Control Consortium 2 (WTCCC2); Jaddoe VW, Starr JM, Verhulst FC, Pennell C, Tiemeier H, Iacono WG, Palmer LJ, Montgomery GW, Martin NG, Boomsma DI, Posthuma D, McGue M, Wright MJ, Davey Smith G, Deary IJ, Plomin R, Visscher PM. Benyamin B, et al. Mol Psychiatry. 2014 Feb;19(2):253-8. doi: 10.1038/mp.2012.184. Epub 2013 Jan 29. Mol Psychiatry. 2014. PMID: 23358156 Free PMC article.
Although no individual single-nucleotide polymorphisms (SNPs) were detected with genome-wide significance, we show that the aggregate effects of common SNPs explain 22-46% of phenotypic variation in childhood intelligence in the three largest cohorts (P=3.9 10(-15), 0.014 and 0.0 …
Although no individual single-nucleotide polymorphisms (SNPs) were detected with genome-wide significance, we show that the aggregate effect …
Filopodial protrusion driven by density-dependent Ena-TOCA-1 interactions.
Blake TCA, Fox HM, Urbančič V, Ravishankar R, Wolowczyk A, Allgeyer ES, Mason J, Danuser G, Gallop JL. Blake TCA, et al. J Cell Sci. 2024 Mar 15;137(6):jcs261057. doi: 10.1242/jcs.261057. Epub 2024 Mar 21. J Cell Sci. 2024. PMID: 38323924 Free PMC article.
To explore the significance of the F-BAR domain-containing neuronal membrane adaptor TOCA-1 (also known as FNBP1L) in filopodia we performed a quantitative analysis of TOCA-1 and filopodial dynamics in Xenopus retinal ganglion cells, where Ena/VASP proteins have a native r …
To explore the significance of the F-BAR domain-containing neuronal membrane adaptor TOCA-1 (also known as FNBP1L) in filopodia we pe …
Canine cutaneous peripheral nerve sheath tumours versus fibrosarcomas can be differentiated by neuroectodermal marker genes in their transcriptome.
Klopfleisch R, Meyer A, Lenze D, Hummel M, Gruber AD. Klopfleisch R, et al. J Comp Pathol. 2013 Feb;148(2-3):197-205. doi: 10.1016/j.jcpa.2012.06.004. Epub 2012 Jul 19. J Comp Pathol. 2013. PMID: 22818216
Conversely, eight genes associated with carcinogenesis had higher expression in fibrosarcomas: FHL2, PLAGL1, FNBP1L, BAG2, HK1, CSK and Cox5A. Comparison of the fibrosarcoma and PNST transcriptome therefore identified PNST phenotype-associated genes involved in neuroectode …
Conversely, eight genes associated with carcinogenesis had higher expression in fibrosarcomas: FHL2, PLAGL1, FNBP1L, BAG2, HK1, CSK a …
Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis.
Chander H, Brien CD, Truesdell P, Watt K, Meens J, Schick C, Germain D, Craig AW. Chander H, et al. Breast Cancer Res. 2014 Dec 30;16(6):3413. doi: 10.1186/s13058-014-0503-x. Breast Cancer Res. 2014. PMID: 25547174 Free PMC article.
METHODS: Normal mammary epithelial cells (HBL-100, MCF10A) and breast cancer cell lines expressing wild-type (WT) p53 (DU4475, MTLn3) were treated with camptothecin or Nutlin-3 to stabilize p53 to test effects on Toca-1 mRNA and protein levels. ...CONCLUSIONS: Based on the …
METHODS: Normal mammary epithelial cells (HBL-100, MCF10A) and breast cancer cell lines expressing wild-type (WT) p53 (DU4475, MTLn3) …
Transducer of Cdc42-dependent actin assembly promotes breast cancer invasion and metastasis.
Chander H, Truesdell P, Meens J, Craig AW. Chander H, et al. Oncogene. 2013 Jun 20;32(25):3080-90. doi: 10.1038/onc.2012.317. Epub 2012 Jul 23. Oncogene. 2013. PMID: 22824798
Here, we report that the adaptor protein transducer of Cdc42-dependent actin assembly-1 (Toca-1) is expressed in highly invasive breast cancers and regulates their metastatic phenotypes. We show that Toca-1 localizes to the filamentous actin-rich core of invadopodial protr …
Here, we report that the adaptor protein transducer of Cdc42-dependent actin assembly-1 (Toca-1) is expressed in highly invasive breast c …
Cdc42-interacting protein 4 promotes breast cancer cell invasion and formation of invadopodia through activation of N-WASp.
Pichot CS, Arvanitis C, Hartig SM, Jensen SA, Bechill J, Marzouk S, Yu J, Frost JA, Corey SJ. Pichot CS, et al. Cancer Res. 2010 Nov 1;70(21):8347-56. doi: 10.1158/0008-5472.CAN-09-4149. Epub 2010 Oct 12. Cancer Res. 2010. PMID: 20940394 Free PMC article.
We found that expression of CIP4, but not TOCA-1 or FBP17, was increased in invasive breast cancer cell lines in comparison with weakly or noninvasive breast cancer cell lines. ...This study presents a new role for CIP4 in the promotion of migration and invasion of …
We found that expression of CIP4, but not TOCA-1 or FBP17, was increased in invasive breast cancer cell lines in comparison with weak …
Construction and Validation of an Immune-Related Gene Prognostic Index for Esophageal Squamous Cell Carcinoma.
Ji Q, Cai Y, Shrestha SM, Shen D, Zhao W, Shi R. Ji Q, et al. Biomed Res Int. 2021 Oct 21;2021:7430315. doi: 10.1155/2021/7430315. eCollection 2021. Biomed Res Int. 2021. PMID: 34722771 Free PMC article.
Immune checkpoint inhibitor (ICI) therapy may benefit patients with advanced esophageal squamous cell carcinoma (ESCC); however, novel biomarkers are needed to help predict the response of patients to treatment. Differentially expressed immune-related genes within The Cancer …
Immune checkpoint inhibitor (ICI) therapy may benefit patients with advanced esophageal squamous cell carcinoma (ESCC); however, novel bioma …
15 results