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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1991 1
1992 2
1993 3
1994 5
1995 7
1996 1
1997 3
1998 3
1999 2
2000 2
2001 3
2002 5
2003 7
2004 8
2005 10
2006 5
2007 10
2008 9
2009 13
2010 16
2011 15
2012 13
2013 15
2014 18
2015 27
2016 25
2017 30
2018 28
2019 37
2020 32
2021 36
2022 32
2023 45
2024 14

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429 results

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Page 1
FOXA2 drives lineage plasticity and KIT pathway activation in neuroendocrine prostate cancer.
Han M, Li F, Zhang Y, Dai P, He J, Li Y, Zhu Y, Zheng J, Huang H, Bai F, Gao D. Han M, et al. Cancer Cell. 2022 Nov 14;40(11):1306-1323.e8. doi: 10.1016/j.ccell.2022.10.011. Epub 2022 Nov 3. Cancer Cell. 2022. PMID: 36332622 Free article.
We identify that FOXA2 orchestrates prostate cancer adeno-to-neuroendocrine lineage transition and that Foxa2 expression is significantly induced by androgen deprivation. ...The KIT pathway is directly regulated by FOXA2 and specifically activated in n …
We identify that FOXA2 orchestrates prostate cancer adeno-to-neuroendocrine lineage transition and that Foxa2 expressio …
Genomic analyses identify molecular subtypes of pancreatic cancer.
Bailey P, Chang DK, Nones K, Johns AL, Patch AM, Gingras MC, Miller DK, Christ AN, Bruxner TJ, Quinn MC, Nourse C, Murtaugh LC, Harliwong I, Idrisoglu S, Manning S, Nourbakhsh E, Wani S, Fink L, Holmes O, Chin V, Anderson MJ, Kazakoff S, Leonard C, Newell F, Waddell N, Wood S, Xu Q, Wilson PJ, Cloonan N, Kassahn KS, Taylor D, Quek K, Robertson A, Pantano L, Mincarelli L, Sanchez LN, Evers L, Wu J, Pinese M, Cowley MJ, Jones MD, Colvin EK, Nagrial AM, Humphrey ES, Chantrill LA, Mawson A, Humphris J, Chou A, Pajic M, Scarlett CJ, Pinho AV, Giry-Laterriere M, Rooman I, Samra JS, Kench JG, Lovell JA, Merrett ND, Toon CW, Epari K, Nguyen NQ, Barbour A, Zeps N, Moran-Jones K, Jamieson NB, Graham JS, Duthie F, Oien K, Hair J, Grützmann R, Maitra A, Iacobuzio-Donahue CA, Wolfgang CL, Morgan RA, Lawlor RT, Corbo V, Bassi C, Rusev B, Capelli P, Salvia R, Tortora G, Mukhopadhyay D, Petersen GM; Australian Pancreatic Cancer Genome Initiative; Munzy DM, Fisher WE, Karim SA, Eshleman JR, Hruban RH, Pilarsky C, Morton JP, Sansom OJ, Scarpa A, Musgrove EA, Bailey UM, Hofmann O, Sutherland RL, Wheeler DA, Gill AJ, Gibbs RA, Pearson JV, Waddell N, Biankin AV, Grimmond SM. Bailey P, et al. Nature. 2016 Mar 3;531(7592):47-52. doi: 10.1038/nature16965. Epub 2016 Feb 24. Nature. 2016. PMID: 26909576
Pancreatic progenitor tumours preferentially express genes involved in early pancreatic development (FOXA2/3, PDX1 and MNX1). ADEX tumours displayed upregulation of genes that regulate networks involved in KRAS activation, exocrine (NR5A2 and RBPJL), and endocrine differen …
Pancreatic progenitor tumours preferentially express genes involved in early pancreatic development (FOXA2/3, PDX1 and MNX1). ADEX tu …
FOXA2 promotes esophageal cancer migration and metastasis by activating CXCR4 expression.
Chen Z, Xiao Q, Shen Y, Xue C. Chen Z, et al. Biochem Biophys Res Commun. 2022 Oct 15;625:16-22. doi: 10.1016/j.bbrc.2022.07.085. Epub 2022 Jul 31. Biochem Biophys Res Commun. 2022. PMID: 35944359
The expression of FOXA2 was upregulated in esophageal cancer tissues and positively correlated with CXCR4. Moreover, knockout of FOXA2 significantly inhibited esophageal cancer migration and metastasis, which can be rescued by ectopically expressed CXC …
The expression of FOXA2 was upregulated in esophageal cancer tissues and positively correlated with CXCR4. Moreover, knockout …
FOXA1 and FOXA2: the regulatory mechanisms and therapeutic implications in cancer.
Liu N, Wang A, Xue M, Zhu X, Liu Y, Chen M. Liu N, et al. Cell Death Discov. 2024 Apr 11;10(1):172. doi: 10.1038/s41420-024-01936-1. Cell Death Discov. 2024. PMID: 38605023 Free PMC article. Review.
This article focuses on the molecular mechanisms and clinical relevance of FOXA1 and FOXA2 in steroid hormone-induced malignancies and highlights potential strategies for targeting FOXA1 and FOXA2 for cancer therapy. Furthermore, the article describes the pro …
This article focuses on the molecular mechanisms and clinical relevance of FOXA1 and FOXA2 in steroid hormone-induced malignancies an …
FOXA2 promotes prostate cancer growth in the bone.
Connelly ZM, Jin R, Zhang J, Yang S, Cheng S, Shi M, Cates JM, Shi R, DeGraff DJ, Nelson PS, Liu Y, Morrissey C, Corey E, Yu X. Connelly ZM, et al. Am J Transl Res. 2020 Sep 15;12(9):5619-5629. eCollection 2020. Am J Transl Res. 2020. PMID: 33042443 Free PMC article.
To determine the functional role of FOXA2 in PCa metastasis, we knocked down the expression of FOXA2 in PCa PC3 cells, which can grow in bones and elicit an osteolytic reaction. ...These results indicate that FOXA2 is involved in PCa bone metastasis....
To determine the functional role of FOXA2 in PCa metastasis, we knocked down the expression of FOXA2 in PCa PC3 cells, which c …
Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer.
Teng S, Li YE, Yang M, Qi R, Huang Y, Wang Q, Zhang Y, Chen S, Li S, Lin K, Cao Y, Ji Q, Gu Q, Cheng Y, Chang Z, Guo W, Wang P, Garcia-Bassets I, Lu ZJ, Wang D. Teng S, et al. Cell Res. 2020 Jan;30(1):34-49. doi: 10.1038/s41422-019-0259-z. Epub 2019 Dec 6. Cell Res. 2020. PMID: 31811277 Free PMC article.
Metastasis, the development of secondary malignant growths at a distance from a primary tumor, is the cause of death for 90% of cancer patients, but little is known about how metastatic cancer cells adapt to and colonize new tissue environments. ...Further, we ident …
Metastasis, the development of secondary malignant growths at a distance from a primary tumor, is the cause of death for 90% of cancer …
FOXA2 Suppression by TRIM36 Exerts Anti-Tumor Role in Colorectal Cancer Via Inducing NRF2/GPX4-Regulated Ferroptosis.
Liu X, Yan C, Chang C, Meng F, Shen W, Wang S, Zhang Y. Liu X, et al. Adv Sci (Weinh). 2023 Dec;10(35):e2304521. doi: 10.1002/advs.202304521. Epub 2023 Oct 24. Adv Sci (Weinh). 2023. PMID: 37875418 Free PMC article.
Notably, a positive correlation between FOXA2 and nuclear factor erythroid 2-related factor 2 (Nrf2)/glutathione peroxidase 4 (GPX4) gene expression is observed in CRC patients. ...More intriguingly, the E3 ubiquitin ligase tripartite motif containing 36 (TRIM36) is identi …
Notably, a positive correlation between FOXA2 and nuclear factor erythroid 2-related factor 2 (Nrf2)/glutathione peroxidase 4 (GPX4) …
Ginger nanoparticles mediated induction of Foxa2 prevents high-fat diet-induced insulin resistance.
Kumar A, Sundaram K, Teng Y, Mu J, Sriwastva MK, Zhang L, Hood JL, Yan J, Zhang X, Park JW, Merchant ML, Zhang HG. Kumar A, et al. Theranostics. 2022 Jan 1;12(3):1388-1403. doi: 10.7150/thno.62514. eCollection 2022. Theranostics. 2022. PMID: 35154496 Free PMC article.
Surface plasmon resonance (SPR) was used for determining the interaction between Foxa2 protein and phosphatic acid lipid nanoparticles. Results: HFD-feeding inhibited the expression of Foxa2; the GDNPs increased the expression of Foxa2 and protected Foxa2 …
Surface plasmon resonance (SPR) was used for determining the interaction between Foxa2 protein and phosphatic acid lipid nanoparticle …
Single-cell transcriptional regulation and genetic evolution of neuroendocrine prostate cancer.
Wang Z, Wang T, Hong D, Dong B, Wang Y, Huang H, Zhang W, Lian B, Ji B, Shi H, Qu M, Gao X, Li D, Collins C, Wei G, Xu C, Lee HJ, Huang J, Li J. Wang Z, et al. iScience. 2022 Jun 13;25(7):104576. doi: 10.1016/j.isci.2022.104576. eCollection 2022 Jul 15. iScience. 2022. PMID: 35789834 Free PMC article.
Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer, with a 10% five-year survival rate. ...Third, we inferred a hierarchical transcription factor (TF) network underlying the progression, which involves constitutive regulation by ASCL1, F …
Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer, with a 10% five-year survival rate. ...Third, we …
CD44 Promotes Breast Cancer Metastasis through AKT-Mediated Downregulation of Nuclear FOXA2.
Vadhan A, Hou MF, Vijayaraghavan P, Wu YC, Hu SC, Wang YM, Cheng TL, Wang YY, Yuan SF. Vadhan A, et al. Biomedicines. 2022 Oct 5;10(10):2488. doi: 10.3390/biomedicines10102488. Biomedicines. 2022. PMID: 36289750 Free PMC article.
The primary cause of breast cancer mortality is the metastatic invasion of cancerous stem cells (CSC). ...CD44 is a cell-membrane embedded protein, and it interacts with different proteins to regulate cancer cell behavior. Transcription factor forkhead box pr …
The primary cause of breast cancer mortality is the metastatic invasion of cancerous stem cells (CSC). ...CD44 is a cell-membr …
429 results