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Immunogenetics of autoimmune thyroid diseases: A comprehensive review.
Lee HJ, Li CW, Hammerstad SS, Stefan M, Tomer Y. Lee HJ, et al. J Autoimmun. 2015 Nov;64:82-90. doi: 10.1016/j.jaut.2015.07.009. Epub 2015 Jul 30. J Autoimmun. 2015. PMID: 26235382 Free PMC article. Review.
Both environmental and genetic triggers factor into the etiology of autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT). ...Of the AITD susceptibility genes, FOXP3 and CD25 play critical role …
Both environmental and genetic triggers factor into the etiology of autoimmune thyroid disease (AITD), including Graves' disease …
Thyroid autoimmunity.
Wiersinga WM. Wiersinga WM. Endocr Dev. 2014;26:139-57. doi: 10.1159/000363161. Epub 2014 Aug 29. Endocr Dev. 2014. PMID: 25231450 Review.
Breakdown of tolerance to thyroid antigens can result in thyroid autoimmunity, which may happen in subjects who have the wrong genes and who are exposed to the wrong environment. Polymorphisms in thyroid genes (TG, TSHR) and immunoregulatory genes (HLA, CTLA4 …
Breakdown of tolerance to thyroid antigens can result in thyroid autoimmunity, which may happen in subjects who have the wrong genes …
The role behind the scenes of Tregs and Th17s in Hashimoto's thyroiditis: Toward a pivotal role of FOXP3 and BACH2.
Mazzieri A, Montanucci P, Basta G, Calafiore R. Mazzieri A, et al. Front Immunol. 2022 Dec 12;13:1098243. doi: 10.3389/fimmu.2022.1098243. eCollection 2022. Front Immunol. 2022. PMID: 36578493 Free PMC article. Review.
In Hashimoto's thyroiditis (HT), the genetic bases play a central role in determining development of the disease. In particular, the most frequent genes involved in the onset of HT are the Human Leukocyte Antigen (HLA). ...
In Hashimoto's thyroiditis (HT), the genetic bases play a central role in determining development of the disease. In pa …
Association and gene-gene interaction analyses for polymorphic variants in CTLA-4 and FOXP3 genes: role in susceptibility to autoimmune thyroid disease.
Fathima N, Narne P, Ishaq M. Fathima N, et al. Endocrine. 2019 Jun;64(3):591-604. doi: 10.1007/s12020-019-01859-3. Epub 2019 Feb 15. Endocrine. 2019. PMID: 30771152
We analyzed the association between CTLA-4 rs231775 and FOXP3 rs3761548, rs3761549 polymorphisms and predisposition to autoimmune thyroid disease (AITD), inclusive of Hashimoto's thyroiditis (HT) and Graves' disease (GD) in South-Indian populati …
We analyzed the association between CTLA-4 rs231775 and FOXP3 rs3761548, rs3761549 polymorphisms and predisposition to autoimmune thy …
Dioscin alleviates hashimoto's thyroiditis by regulating the SUMOylation of IRF4 to promote CD4(+)CD25(+)Foxp3(+) treg cell differentiation.
Yongjun C, Nan Q, Yumeng S, Xiaowen J, Weibo W. Yongjun C, et al. Autoimmunity. 2021 Feb;54(1):51-59. doi: 10.1080/08916934.2020.1855428. Epub 2020 Dec 4. Autoimmunity. 2021. PMID: 33274645
Dioscin has been used as a treatment for Hashimoto's thyroiditis (HT) in China. However, the molecular mechanisms governing the modes of action of dioscin have not been elucidated. ...After oral administration of dioscin each day for two weeks, CD4(+)CD25(+)Foxp3 …
Dioscin has been used as a treatment for Hashimoto's thyroiditis (HT) in China. However, the molecular mechanisms governing th …
Genetic and epigenetic mechanisms in thyroid autoimmunity.
Hasham A, Tomer Y. Hasham A, et al. Immunol Res. 2012 Dec;54(1-3):204-13. doi: 10.1007/s12026-012-8302-x. Immunol Res. 2012. PMID: 22457094 Free PMC article. Review.
Autoimmune thyroid diseases (AITD), including Graves' disease and Hashimoto's thyroiditis, are among the commonest autoimmune disorders, affecting approximately 5 % of the population. ...We have shown that an amino acid substitution of alanine or glutamine wi …
Autoimmune thyroid diseases (AITD), including Graves' disease and Hashimoto's thyroiditis, are among the commonest auto …
X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis.
Asselta R, Paraboschi EM, Gerussi A, Cordell HJ, Mells GF, Sandford RN, Jones DE, Nakamura M, Ueno K, Hitomi Y, Kawashima M, Nishida N, Tokunaga K, Nagasaki M, Tanaka A, Tang R, Li Z, Shi Y, Liu X, Xiong M, Hirschfield G, Siminovitch KA; Canadian-US PBC Consortium; Italian PBC Genetics Study Group; UK-PBC Consortium; Japan PBC-GWAS Consortium; Carbone M, Cardamone G, Duga S, Gershwin ME, Seldin MF, Invernizzi P. Asselta R, et al. Gastroenterology. 2021 Jun;160(7):2483-2495.e26. doi: 10.1053/j.gastro.2021.02.061. Epub 2021 Mar 4. Gastroenterology. 2021. PMID: 33675743 Free PMC article.
Indeed, rs7059064 tags a unique linkage disequilibrium block including 7 genes: TIMM17B, PQBP1, PIM2, SLC35A2, OTUD5, KCND1, and GRIPAP1, as well as a superenhancer (GH0XJ048933 within OTUD5) targeting all these genes. GH0XJ048933 is also predicted to target FOXP …
Indeed, rs7059064 tags a unique linkage disequilibrium block including 7 genes: TIMM17B, PQBP1, PIM2, SLC35A2, OTUD5, KCND1, and GRIP …
Mechanisms in endocrinology: autoimmune thyroid disease: old and new players.
Effraimidis G, Wiersinga WM. Effraimidis G, et al. Eur J Endocrinol. 2014 Jun;170(6):R241-52. doi: 10.1530/EJE-14-0047. Epub 2014 Mar 7. Eur J Endocrinol. 2014. PMID: 24609834 Review.
The number of identified susceptibility genes for AITD is increasing (among others now including TSHR, TG, HLA, CTLA4, PTPN22, CD40, FCRL3, IL2RA, and FOXP3), but these genes together probably do not explain more than about 10% of the heritability of AITD. .. …
The number of identified susceptibility genes for AITD is increasing (among others now including TSHR, TG, HLA, CTLA4, PTPN22, CD40, …
IL-17 A correlates with disease progression in papillary thyroid carcinoma.
Banerjee S, Nahar U, Dahiya D, Gupta R, Mukherjee S, Sachdeva N, Sood A, Dey P, Radotra B, Bhansali A. Banerjee S, et al. Diagn Pathol. 2023 Aug 10;18(1):93. doi: 10.1186/s13000-023-01362-4. Diagn Pathol. 2023. PMID: 37563607 Free PMC article.
METHODS: Cytometric Bead Array (CBA) analysis of pro and anti-inflammatory cytokines (IFN-gamma, IL-2, IL-6, IL-17 A, TNF-alpha and IL-4, IL-10) was done in 15 PTC irrespective of Lymphocytic Thyroiditis (LT) and 16 Hashimoto's Thyroiditis (HT) cases. Immunohistoche …
METHODS: Cytometric Bead Array (CBA) analysis of pro and anti-inflammatory cytokines (IFN-gamma, IL-2, IL-6, IL-17 A, TNF-alpha and IL-4, IL …
Novel missense mutation in PTPN22 in a Chinese pedigree with Hashimoto's thyroiditis.
Gong L, Liu B, Wang J, Pan H, Qi A, Zhang S, Wu J, Yang P, Wang B. Gong L, et al. BMC Endocr Disord. 2018 Nov 1;18(1):76. doi: 10.1186/s12902-018-0305-8. BMC Endocr Disord. 2018. PMID: 30384852 Free PMC article.
BACKGROUND: Hashimoto's thyroiditis is a complex autoimmune thyroid disease, the onset of which is associated with environmental exposures and specific susceptibility genes. ...Our study, for the first time, linked a rare variant of PTPN22 to Hashim …
BACKGROUND: Hashimoto's thyroiditis is a complex autoimmune thyroid disease, the onset of which is associated with envi …
24 results