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2000 1
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2014 12
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2020 12
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The circACTN4 interacts with FUBP1 to promote tumorigenesis and progression of breast cancer by regulating the expression of proto-oncogene MYC.
Wang X, Xing L, Yang R, Chen H, Wang M, Jiang R, Zhang L, Chen J. Wang X, et al. Mol Cancer. 2021 Jun 11;20(1):91. doi: 10.1186/s12943-021-01383-x. Mol Cancer. 2021. PMID: 34116677 Free PMC article.
Further mechanistic research proved that circACTN4 could competitively bind to far upstream element binding protein 1 (FUBP1) to prevent the combination between FUBP1 and FIR, thereby activating MYC transcription and facilitating tumor progression of breast cance …
Further mechanistic research proved that circACTN4 could competitively bind to far upstream element binding protein 1 (FUBP1) to prev …
Irinotecan: 25 years of cancer treatment.
Bailly C. Bailly C. Pharmacol Res. 2019 Oct;148:104398. doi: 10.1016/j.phrs.2019.104398. Epub 2019 Aug 12. Pharmacol Res. 2019. PMID: 31415916 Review.
Twenty-five years ago, the cytotoxic drug irinotecan (IRT) was first approved in Japan for the treatment of cancer. For more than two decades, the IRT prodrug has largely contributed to the treatment of solid tumors worldwide. ...New information about the IRT mechanism of …
Twenty-five years ago, the cytotoxic drug irinotecan (IRT) was first approved in Japan for the treatment of cancer. For more than two …
The NR_109/FUBP1/c-Myc axis regulates TAM polarization and remodels the tumor microenvironment to promote cancer development.
Zhang C, Wei S, Dai S, Li X, Wang H, Zhang H, Sun G, Shan B, Zhao L. Zhang C, et al. J Immunother Cancer. 2023 May;11(5):e006230. doi: 10.1136/jitc-2022-006230. J Immunother Cancer. 2023. PMID: 37217247 Free PMC article.
Clinically, high NR_109 expression was found in CD163(+) TAMs from tumor tissues and was positively correlated with poor clinical stages of patients with gastric cancer and breast cancer. CONCLUSIONS: Our work revealed for the first time that NR_109 exerted a crucia …
Clinically, high NR_109 expression was found in CD163(+) TAMs from tumor tissues and was positively correlated with poor clinical stages of …
FUBP1 promotes colorectal cancer stemness and metastasis via DVL1-mediated activation of Wnt/beta-catenin signaling.
Yin H, Gao T, Xie J, Huang Z, Zhang X, Yang F, Qi W, Yang Z, Zhou T, Gao G, Yang X. Yin H, et al. Mol Oncol. 2021 Dec;15(12):3490-3512. doi: 10.1002/1878-0261.13064. Epub 2021 Jul 29. Mol Oncol. 2021. PMID: 34288405 Free PMC article.
FUBP1 was upregulated in 85% of KRAS-mutant and 25% of wild-type CRC patients. ...Activation of Wnt/beta-catenin signaling by DVL1 increased pluripotent transcription factors, including c-Myc, NANOG, and SOX2. Moreover, FUBP1 was upregulated at the post-transcriptio …
FUBP1 was upregulated in 85% of KRAS-mutant and 25% of wild-type CRC patients. ...Activation of Wnt/beta-catenin signaling by DVL1 in …
Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.
Byun J, Han Y, Li Y, Xia J, Long E, Choi J, Xiao X, Zhu M, Zhou W, Sun R, Bossé Y, Song Z, Schwartz A, Lusk C, Rafnar T, Stefansson K, Zhang T, Zhao W, Pettit RW, Liu Y, Li X, Zhou H, Walsh KM, Gorlov I, Gorlova O, Zhu D, Rosenberg SM, Pinney S, Bailey-Wilson JE, Mandal D, de Andrade M, Gaba C, Willey JC, You M, Anderson M, Wiencke JK, Albanes D, Lam S, Tardon A, Chen C, Goodman G, Bojeson S, Brenner H, Landi MT, Chanock SJ, Johansson M, Muley T, Risch A, Wichmann HE, Bickeböller H, Christiani DC, Rennert G, Arnold S, Field JK, Shete S, Le Marchand L, Melander O, Brunnstrom H, Liu G, Andrew AS, Kiemeney LA, Shen H, Zienolddiny S, Grankvist K, Johansson M, Caporaso N, Cox A, Hong YC, Yuan JM, Lazarus P, Schabath MB, Aldrich MC, Patel A, Lan Q, Rothman N, Taylor F, Kachuri L, Witte JS, Sakoda LC, Spitz M, Brennan P, Lin X, McKay J, Hung RJ, Amos CI. Byun J, et al. Nat Genet. 2022 Aug;54(8):1167-1177. doi: 10.1038/s41588-022-01115-x. Epub 2022 Aug 1. Nat Genet. 2022. PMID: 35915169 Free PMC article.
To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loci that have not been previously reported. ...Fine-mapping and ex …
To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association stu …
Pan-Cancer Transcriptome and Immune Infiltration Analyses Reveal the Oncogenic Role of Far Upstream Element-Binding Protein 1 (FUBP1).
Wang H, Zhang R, Li E, Yan R, Ma B, Ma Q. Wang H, et al. Front Mol Biosci. 2022 Feb 22;9:794715. doi: 10.3389/fmolb.2022.794715. eCollection 2022. Front Mol Biosci. 2022. PMID: 35274005 Free PMC article.
Despite increasing evidence to support the relationship between FUBP1 and tumorigenesis in some types of cancers, there have been no analyses from a pan-cancer perspective. ...Dysregulated FUBP1 expression was observed in most cancer types, and …
Despite increasing evidence to support the relationship between FUBP1 and tumorigenesis in some types of cancers, there have b …
FUBP1 mediates the growth and metastasis through TGFbeta/Smad signaling in pancreatic adenocarcinoma.
Zhang Y, Chen J, Zhou N, Lu Y, Lu J, Xing X, Chen H, Zhang X. Zhang Y, et al. Int J Mol Med. 2021 May;47(5):66. doi: 10.3892/ijmm.2021.4899. Epub 2021 Mar 2. Int J Mol Med. 2021. PMID: 33649780 Free PMC article.
Recent studies have reported that the expression levels of far upstream element-binding protein 1 (FUBP1) were upregulated and served a crucial role in several types of cancer. ...FUBP1 expression levels and survival outcomes in patients with PAAD were analyz …
Recent studies have reported that the expression levels of far upstream element-binding protein 1 (FUBP1) were upregulated and served …
FUBP1 is a general splicing factor facilitating 3' splice site recognition and splicing of long introns.
Ebersberger S, Hipp C, Mulorz MM, Buchbender A, Hubrich D, Kang HS, Martínez-Lumbreras S, Kristofori P, Sutandy FXR, Llacsahuanga Allcca L, Schönfeld J, Bakisoglu C, Busch A, Hänel H, Tretow K, Welzel M, Di Liddo A, Möckel MM, Zarnack K, Ebersberger I, Legewie S, Luck K, Sattler M, König J. Ebersberger S, et al. Mol Cell. 2023 Aug 3;83(15):2653-2672.e15. doi: 10.1016/j.molcel.2023.07.002. Epub 2023 Jul 27. Mol Cell. 2023. PMID: 37506698 Free article.
Transcriptional profiling and kinetic modeling reveal that FUBP1 is required for efficient splicing of long introns, which is impaired in cancer patients harboring FUBP1 mutations. Notably, FUBP1 interacts with numerous U1 snRNP-associated proteins, su …
Transcriptional profiling and kinetic modeling reveal that FUBP1 is required for efficient splicing of long introns, which is impaire …
Far upstream element -binding protein 1 (FUBP1) participates in the malignant process and glycolysis of colon cancer cells by combining with c-Myc.
Wang S, Wang Y, Li S, Nian S, Xu W, Liang F. Wang S, et al. Bioengineered. 2022 May;13(5):12115-12126. doi: 10.1080/21655979.2022.2073115. Bioengineered. 2022. PMID: 35546072 Free PMC article.
Therefore, the present study aimed to investigate whether FUBP1 could combine with c-Myc to participate in the progression of colon cancer. ...The results indicated that FUBP1 could participate in the deterioration process of colon cancer cells by comb …
Therefore, the present study aimed to investigate whether FUBP1 could combine with c-Myc to participate in the progression of colon …
Effect of RNA Interference Inhibiting the Expression of the FUBP1 Gene on Biological Function of Gastric Cancer Cell Line SGC7901.
Zhang F, Zhang Y, Wang Y. Zhang F, et al. Turk J Gastroenterol. 2021 Nov;32(11):923-931. doi: 10.5152/tjg.2020.19513. Turk J Gastroenterol. 2021. PMID: 34872893 Free PMC article.
METHODS: The shRNA lentivirus vector of the target gene FUBP1 was constructed to transfect the gastric cancer cell line SGC7901. ...RESULTS: The shRNA lentiviral vector of FUBP1 was successfully transfected into the gastric cancer cell line SGC7901, an …
METHODS: The shRNA lentivirus vector of the target gene FUBP1 was constructed to transfect the gastric cancer cell line SGC790 …
180 results