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Exploring antiviral and anti-inflammatory effects of thiol drugs in COVID-19.
Khanna K, Raymond WW, Jin J, Charbit AR, Gitlin I, Tang M, Werts AD, Barrett EG, Cox JM, Birch SM, Martinelli R, Sperber HS, Franz S, Duff T, Hoffmann M, Healy AM, Oscarson S, Pöhlmann S, Pillai SK, Simmons G, Fahy JV. Khanna K, et al. Among authors: fahy jv. Am J Physiol Lung Cell Mol Physiol. 2022 Sep 1;323(3):L372-L389. doi: 10.1152/ajplung.00136.2022. Epub 2022 Jun 28. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35762590 Free PMC article.
Intelectin-1 is a prominent protein constituent of pathologic mucus associated with eosinophilic airway inflammation in asthma.
Kerr SC, Carrington SD, Oscarson S, Gallagher ME, Solon M, Yuan S, Ahn JN, Dougherty RH, Finkbeiner WE, Peters MC, Fahy JV. Kerr SC, et al. Among authors: fahy jv. Am J Respir Crit Care Med. 2014 Apr 15;189(8):1005-7. doi: 10.1164/rccm.201312-2220LE. Am J Respir Crit Care Med. 2014. PMID: 24735037 Free PMC article. No abstract available.
Mucus secretion blocked at its source in the lungs.
Gitlin I, Fahy JV. Gitlin I, et al. Among authors: fahy jv. Nature. 2022 Mar;603(7903):798-799. doi: 10.1038/d41586-022-00700-8. Nature. 2022. PMID: 35322214 No abstract available.
FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection.
Kerr SC, Fischer GJ, Sinha M, McCabe O, Palmer JM, Choera T, Lim FY, Wimmerova M, Carrington SD, Yuan S, Lowell CA, Oscarson S, Keller NP, Fahy JV. Kerr SC, et al. Among authors: fahy jv. PLoS Pathog. 2016 Apr 8;12(4):e1005555. doi: 10.1371/journal.ppat.1005555. eCollection 2016 Apr. PLoS Pathog. 2016. PMID: 27058347 Free PMC article.
Oxidation increases mucin polymer cross-links to stiffen airway mucus gels.
Yuan S, Hollinger M, Lachowicz-Scroggins ME, Kerr SC, Dunican EM, Daniel BM, Ghosh S, Erzurum SC, Willard B, Hazen SL, Huang X, Carrington SD, Oscarson S, Fahy JV. Yuan S, et al. Among authors: fahy jv. Sci Transl Med. 2015 Feb 25;7(276):276ra27. doi: 10.1126/scitranslmed.3010525. Sci Transl Med. 2015. PMID: 25717100 Free PMC article.
Thiol drugs decrease SARS-CoV-2 lung injury in vivo and disrupt SARS-CoV-2 spike complex binding to ACE2 in vitro.
Khanna K, Raymond W, Jin J, Charbit AR, Gitlin I, Tang M, Werts AD, Barrett EG, Cox JM, Birch SM, Martinelli R, Sperber HS, Franz S, Pillai S, Healy AM, Duff T, Oscarson S, Hoffmann M, Pöhlmann S, Simmons G, Fahy JV. Khanna K, et al. Among authors: fahy jv. bioRxiv [Preprint]. 2021 Nov 11:2020.12.08.415505. doi: 10.1101/2020.12.08.415505. bioRxiv. 2021. PMID: 33330868 Free PMC article. Preprint.
249 results