Falchi F - Search Results

1

Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3σ case.

Corradi V, Mancini M, Santucci MA, Carlomagno T, Sanfelice D, Mori M, Vignaroli G, Falchi F, Manetti F, Radi M, Botta M. Corradi V, et al. Among authors: falchi f. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6867-71. doi: 10.1016/j.bmcl.2011.09.011. Epub 2011 Sep 10. Bioorg Med Chem Lett. 2011. PMID: 21962576

2

Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents.

Radi M, Crespan E, Botta G, Falchi F, Maga G, Manetti F, Corradi V, Mancini M, Santucci MA, Schenone S, Botta M. Radi M, et al. Among authors: falchi f. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1207-11. doi: 10.1016/j.bmcl.2007.11.112. Epub 2007 Dec 4. Bioorg Med Chem Lett. 2008. PMID: 18078752

3

N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds.

Manetti F, Falchi F, Crespan E, Schenone S, Maga G, Botta M. Manetti F, et al. Among authors: falchi f. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4328-31. doi: 10.1016/j.bmcl.2008.06.082. Epub 2008 Jun 28. Bioorg Med Chem Lett. 2008. PMID: 18621522

4

Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3.

Maga G, Falchi F, Garbelli A, Belfiore A, Witvrouw M, Manetti F, Botta M. Maga G, et al. Among authors: falchi f. J Med Chem. 2008 Nov 13;51(21):6635-8. doi: 10.1021/jm8008844. Epub 2008 Oct 4. J Med Chem. 2008. PMID: 18834110

5

3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors.

Falchi F, Manetti F, Carraro F, Naldini A, Maga G, Crespan E, Schenone S, Bruno O, Brullo C, Botta M. Falchi F, et al. ChemMedChem. 2009 Jun;4(6):976-87. doi: 10.1002/cmdc.200800441. ChemMedChem. 2009. PMID: 19326384

6

Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data.

Dreassi E, Zizzari AT, Falchi F, Schenone S, Santucci A, Maga G, Botta M. Dreassi E, et al. Among authors: falchi f. Eur J Med Chem. 2009 Sep;44(9):3712-7. doi: 10.1016/j.ejmech.2009.03.039. Epub 2009 Apr 8. Eur J Med Chem. 2009. PMID: 19410338

7

Design and synthesis of thiadiazoles and thiazoles targeting the Bcr-Abl T315I mutant: from docking false positives to ATP-noncompetitive inhibitors.

Radi M, Crespan E, Falchi F, Bernardo V, Zanoli S, Manetti F, Schenone S, Maga G, Botta M. Radi M, et al. Among authors: falchi f. ChemMedChem. 2010 Aug 2;5(8):1226-31. doi: 10.1002/cmdc.201000066. ChemMedChem. 2010. PMID: 20509136 No abstract available.

8

Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication.

Garbelli A, Radi M, Falchi F, Beermann S, Zanoli S, Manetti F, Dietrich U, Botta M, Maga G. Garbelli A, et al. Among authors: falchi f. Curr Med Chem. 2011;18(20):3015-27. doi: 10.2174/092986711796391688. Curr Med Chem. 2011. PMID: 21651478 Review.

9

Fyn kinase in brain diseases and cancer: the search for inhibitors.

Schenone S, Brullo C, Musumeci F, Biava M, Falchi F, Botta M. Schenone S, et al. Among authors: falchi f. Curr Med Chem. 2011;18(19):2921-42. doi: 10.2174/092986711796150531. Curr Med Chem. 2011. PMID: 21651487 Review.

10

Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation.

Maga G, Falchi F, Radi M, Botta L, Casaluce G, Bernardini M, Irannejad H, Manetti F, Garbelli A, Samuele A, Zanoli S, Esté JA, Gonzalez E, Zucca E, Paolucci S, Baldanti F, De Rijck J, Debyser Z, Botta M. Maga G, et al. Among authors: falchi f. ChemMedChem. 2011 Aug 1;6(8):1371-89. doi: 10.1002/cmdc.201100166. Epub 2011 Jun 22. ChemMedChem. 2011. PMID: 21698775

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