Falzone ME - Search Results

1

Structural basis of Ca²⁺-dependent activation and lipid transport by a TMEM16 scramblase.

Falzone ME, Rheinberger J, Lee BC, Peyear T, Sasset L, Raczkowski AM, Eng ET, Di Lorenzo A, Andersen OS, Nimigean CM, Accardi A. Falzone ME, et al. Elife. 2019 Jan 16;8:e43229. doi: 10.7554/eLife.43229. Elife. 2019. PMID: 30648972 Free PMC article.

2

Known structures and unknown mechanisms of TMEM16 scramblases and channels.

Falzone ME, Malvezzi M, Lee BC, Accardi A. Falzone ME, et al. J Gen Physiol. 2018 Jul 2;150(7):933-947. doi: 10.1085/jgp.201711957. Epub 2018 Jun 18. J Gen Physiol. 2018. PMID: 29915161 Free PMC article. Review.

3

Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases.

Malvezzi M, Andra KK, Pandey K, Lee BC, Falzone ME, Brown A, Iqbal R, Menon AK, Accardi A. Malvezzi M, et al. Among authors: falzone me. Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7033-E7042. doi: 10.1073/pnas.1806721115. Epub 2018 Jun 20. Proc Natl Acad Sci U S A. 2018. PMID: 29925604 Free PMC article.

4

Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase.

Lee BC, Khelashvili G, Falzone M, Menon AK, Weinstein H, Accardi A. Lee BC, et al. Nat Commun. 2018 Aug 14;9(1):3251. doi: 10.1038/s41467-018-05724-1. Nat Commun. 2018. PMID: 30108217 Free PMC article.

5

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.

Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP. Bushell SR, et al. Among authors: falzone me. Nat Commun. 2019 Sep 2;10(1):3956. doi: 10.1038/s41467-019-11753-1. Nat Commun. 2019. PMID: 31477691 Free PMC article.

6

Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca²⁺-bound nhTMEM16.

Khelashvili G, Falzone ME, Cheng X, Lee BC, Accardi A, Weinstein H. Khelashvili G, et al. Among authors: falzone me. Nat Commun. 2019 Oct 31;10(1):4972. doi: 10.1038/s41467-019-12865-4. Nat Commun. 2019. PMID: 31672969 Free PMC article.

7

Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins.

Khelashvili G, Cheng X, Falzone ME, Doktorova M, Accardi A, Weinstein H. Khelashvili G, et al. Among authors: falzone me. J Comput Chem. 2020 Mar 5;41(6):538-551. doi: 10.1002/jcc.26105. Epub 2019 Nov 21. J Comput Chem. 2020. PMID: 31750558 Free PMC article.

8

Reconstitution of Proteoliposomes for Phospholipid Scrambling and Nonselective Channel Assays.

Falzone ME, Accardi A. Falzone ME, et al. Methods Mol Biol. 2020;2127:207-225. doi: 10.1007/978-1-0716-0373-4_15. Methods Mol Biol. 2020. PMID: 32112325 Free PMC article.

9

TMEM16 scramblases thin the membrane to enable lipid scrambling.

Falzone ME, Feng Z, Alvarenga OE, Pan Y, Lee B, Cheng X, Fortea E, Scheuring S, Accardi A. Falzone ME, et al. Nat Commun. 2022 May 11;13(1):2604. doi: 10.1038/s41467-022-30300-z. Nat Commun. 2022. PMID: 35562175 Free PMC article.

10

Structural basis of pH-dependent activation in a CLC transporter.

Fortea E, Lee S, Chadda R, Argyros Y, Sandal P, Mahoney-Kruszka R, Ciftci HD, Falzone ME, Huysmans G, Robertson JL, Boudker O, Accardi A. Fortea E, et al. Among authors: falzone me. Nat Struct Mol Biol. 2024 Apr;31(4):644-656. doi: 10.1038/s41594-023-01210-5. Epub 2024 Jan 26. Nat Struct Mol Biol. 2024. PMID: 38279055

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