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Mechanistic studies of choline oxidase with betaine aldehyde and its isosteric analogue 3,3-dimethylbutyraldehyde.
Fan F, Germann MW, Gadda G. Fan F, et al. Biochemistry. 2006 Feb 14;45(6):1979-86. doi: 10.1021/bi0517537. Biochemistry. 2006. PMID: 16460045
The chemical mechanism for the oxidation of choline catalyzed by choline oxidase was recently elucidated by using kinetic isotope effects [Fan, F., and Gadda, G. (2005) J. Am. Chem. Soc. 127, 2067-2074]. ...
The chemical mechanism for the oxidation of choline catalyzed by choline oxidase was recently elucidated by using kinetic isotope effects [ …
An internal equilibrium preorganizes the enzyme-substrate complex for hydride tunneling in choline oxidase.
Fan F, Gadda G. Fan F, et al. Biochemistry. 2007 May 29;46(21):6402-8. doi: 10.1021/bi700255v. Epub 2007 May 2. Biochemistry. 2007. PMID: 17472346
., at saturating oxygen, was shown in a recent study to occur quantum mechanically within a highly preorganized active site, with the reactive configuration for hydride tunneling being minimally affected by environmental vibrations of the reaction coordinate other than those affe …
., at saturating oxygen, was shown in a recent study to occur quantum mechanically within a highly preorganized active site, with the reacti …
2,907 results