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Ubiquitination of NF-kappaB p65 by FBXW2 suppresses breast cancer stemness, tumorigenesis, and paclitaxel resistance.
Ren C, Han X, Lu C, Yang T, Qiao P, Sun Y, Yu Z. Ren C, et al. Cell Death Differ. 2022 Feb;29(2):381-392. doi: 10.1038/s41418-021-00862-4. Epub 2021 Aug 31. Cell Death Differ. 2022. PMID: 34465889 Free PMC article.
However, the functions of FBXW2 in breast cancer are still unknown. Here, we find that nuclear factor-kB (NF-kappaB) p65 is a new substrate of FBXW2. ...Furthermore, FBXW2 induced p65 degradation is also confirmed in FBXW2-knockout mice. ...
However, the functions of FBXW2 in breast cancer are still unknown. Here, we find that nuclear factor-kB (NF-kappaB) p65 is a new sub …
FBXW2 suppresses migration and invasion of lung cancer cells via promoting beta-catenin ubiquitylation and degradation.
Yang F, Xu J, Li H, Tan M, Xiong X, Sun Y. Yang F, et al. Nat Commun. 2019 Mar 27;10(1):1382. doi: 10.1038/s41467-019-09289-5. Nat Commun. 2019. PMID: 30918250 Free PMC article.
FBXW2 inhibits proliferation of lung cancer cells by targeting SKP2 for degradation. ...FBXW2 overexpression reduces beta-catenin levels and protein half-life, whereas FBXW2 knockdown increases beta-catenin levels, protein half-life and transcriptional activi …
FBXW2 inhibits proliferation of lung cancer cells by targeting SKP2 for degradation. ...FBXW2 overexpression reduces beta-cate …
FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis.
Barik GK, Sahay O, Mukhopadhyay A, Manne RK, Islam S, Roy A, Nath S, Santra MK. Barik GK, et al. Cell Death Dis. 2023 Sep 22;14(9):623. doi: 10.1038/s41419-023-06127-x. Cell Death Dis. 2023. PMID: 37736741 Free PMC article.
Our study reveals that Moesin is a cellular target of F-box protein FBXW2. We showed that FBXW2 suppresses breast cancer progression through directing proteasomal degradation of Moesin. In contrast, AKT kinase plays an important role in oncogenic function of Moesin …
Our study reveals that Moesin is a cellular target of F-box protein FBXW2. We showed that FBXW2 suppresses breast cancer progr …
FBXW2 inhibits prostate cancer proliferation and metastasis via promoting EGFR ubiquitylation and degradation.
Zhou T, Chen T, Lai B, Zhang W, Luo X, Xia D, Fu W, Xu J. Zhou T, et al. Cell Mol Life Sci. 2022 May 2;79(5):268. doi: 10.1007/s00018-022-04320-3. Cell Mol Life Sci. 2022. PMID: 35499593 Free PMC article.
However, what the biological functions of FBXW2 in prostate cancer cells and whether FBXW2 targets other substrates to involve in progression of prostate cancer is still unclear. ...Intriguingly, FBXW2 was an E3 ligase for EGFR in prostate cancer. EGFR protei …
However, what the biological functions of FBXW2 in prostate cancer cells and whether FBXW2 targets other substrates to involve …
Role of FBXW2 in explant cultures of bovine periosteum-derived cells.
Akiyama M. Akiyama M. BMC Res Notes. 2021 Nov 4;14(1):410. doi: 10.1186/s13104-021-05825-z. BMC Res Notes. 2021. PMID: 34736516 Free PMC article.
However, the osteoblastic functions of FBXW2 remain unclear. In this study, double-fluorescent immunostaining was used to investigate the potential role of FBXW2 and its relationship with osteocalcin. ...After explant culture, changes in the periosteum were observed …
However, the osteoblastic functions of FBXW2 remain unclear. In this study, double-fluorescent immunostaining was used to investigate …
The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells.
Yin Y, Xie CM, Li H, Tan M, Chen G, Schiff R, Xiong X, Sun Y. Yin Y, et al. Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20528-20538. doi: 10.1073/pnas.1905973116. Epub 2019 Sep 23. Proc Natl Acad Sci U S A. 2019. PMID: 31548378 Free PMC article.
Mechanistic characterization revealed that MSX2 is a substrate of FBXW2 E3 ligase. FBXW2 binds to MSX2 and promotes MSX2 ubiquitylation and degradation. Likewise, FBXW2 overexpression shortens the protein half-life of MSX2, whereas FBXW2 knockdown exte …
Mechanistic characterization revealed that MSX2 is a substrate of FBXW2 E3 ligase. FBXW2 binds to MSX2 and promotes MSX2 ubiqu …
FBXW2 suppresses proliferation and invasion of lung cancer cells by targeting SKP2 and beta-catenin.
Yang F, Sun Y. Yang F, et al. Mol Cell Oncol. 2019 May 8;6(4):1607458. doi: 10.1080/23723556.2019.1607458. eCollection 2019. Mol Cell Oncol. 2019. PMID: 31211237 Free PMC article.
F-box protein is a substrate-receptor of SKP1-Cullin1-F-box protein (SCF) E3 ligase, but the function of many family members remains elusive. We found that F-box and WD-repeat domain-containing 2 (FBXW2) inhibits proliferation and invasion of lung cancer cells by targeting …
F-box protein is a substrate-receptor of SKP1-Cullin1-F-box protein (SCF) E3 ligase, but the function of many family members remains elusive …
E3 Ligase FBXW2 Is a New Therapeutic Target in Obesity and Atherosclerosis.
Wang C, Xu W, Chao Y, Liang M, Zhang F, Huang K. Wang C, et al. Adv Sci (Weinh). 2020 Aug 26;7(20):2001800. doi: 10.1002/advs.202001800. eCollection 2020 Oct. Adv Sci (Weinh). 2020. PMID: 33101872 Free PMC article.
Here, the E3 ubiquitin ligase F-box/WD Repeat-Containing Protein 2 (FBXW2), the substrate-binding subunit of E3 ubiquitin ligase SCF (a complex of FBXW2, SKP1, and cullin-1), as an inflammatory mediator in macrophages, is identified. ...Furthermore, it is demonstrat …
Here, the E3 ubiquitin ligase F-box/WD Repeat-Containing Protein 2 (FBXW2), the substrate-binding subunit of E3 ubiquitin ligase SCF …
FBXW2 localizes with osteocalcin in bovine periosteum on culture dishes as visualized by double immunostaining.
Akiyama M. Akiyama M. Heliyon. 2018 Sep 14;4(9):e00782. doi: 10.1016/j.heliyon.2018.e00782. eCollection 2018 Sep. Heliyon. 2018. PMID: 30229138 Free PMC article.
In this study, double immunostaining was used to investigate the relationship between OC and FBXW2. FBXW2 showed tubular structures, and OC showed a similar localization pattern as FBXW2. Double immunostaining findings suggested that FBXW2 tubes were c …
In this study, double immunostaining was used to investigate the relationship between OC and FBXW2. FBXW2 showed tubular struc …
The beta-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor.
Xu J, Zhou W, Yang F, Chen G, Li H, Zhao Y, Liu P, Li H, Tan M, Xiong X, Sun Y. Xu J, et al. Nat Commun. 2017 Jan 16;8:14002. doi: 10.1038/ncomms14002. Nat Commun. 2017. PMID: 28090088 Free PMC article.
While beta-TrCP1 promotes FBXW2 ubiquitylation and shortens its half-life, FBXW2 does the same to SKP2. ...Finally, the gain- and loss-of-function mutations of FBXW2 are found in various human cancers. Collectively, our data show that the beta-TrCP-FBXW2 …
While beta-TrCP1 promotes FBXW2 ubiquitylation and shortens its half-life, FBXW2 does the same to SKP2. ...Finally, the gain- …
35 results